日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death

SLC25A23 增强线粒体 Ca²⁺ 摄取,与 MCU 相互作用,并诱导氧化应激介导的细胞死亡

Hoffman, Nicholas E; Chandramoorthy, Harish C; Shanmughapriya, Santhanam; Zhang, Xueqian Q; Vallem, Sandhya; Doonan, Patrick J; Malliankaraman, Karthik; Guo, Shuchi; Rajan, Sudarsan; Elrod, John W; Koch, Walter J; Cheung, Joseph Y; Madesh, Muniswamy

MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.

MICU1 是 MCU 介导的线粒体 Ca(2+) 摄取的重要守门人,调节细胞存活

Mallilankaraman Karthik, Doonan Patrick, Cárdenas César, Chandramoorthy Harish C, Müller Marioly, Miller Russell, Hoffman Nicholas E, Gandhirajan Rajesh Kumar, Molgó Jordi, Birnbaum Morris J, Rothberg Brad S, Mak Don-On Daniel, Foskett J Kevin, Madesh Muniswamy

Mitochondrial complex II prevents hypoxic but not calcium- and proapoptotic Bcl-2 protein-induced mitochondrial membrane potential loss.

线粒体复合物 II 可防止缺氧引起的线粒体膜电位丧失,但不能防止钙离子和促凋亡的 Bcl-2 蛋白引起的线粒体膜电位丧失

Hawkins Brian J, Levin Mark D, Doonan Patrick J, Petrenko Nataliya B, Davis Christiana W, Patel Vickas V, Madesh Muniswamy

Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak.

促凋亡的 Bcl-2 相关蛋白 Bid 和 Bak 执行超氧化物诱导的细胞死亡

Madesh Muniswamy, Zong Wei-Xing, Hawkins Brian J, Ramasamy Subbiah, Venkatachalam Thilagavathi, Mukhopadhyay Partha, Doonan Patrick J, Irrinki Krishna M, Rajesh Mohanraj, Pacher Pál, Thompson Craig B