SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress
SGLT2抑制剂通过SAM依赖的表观遗传抑制作用,在代谢应激下保护肾功能,抑制炎症基因的表达。
期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI188933
Maekawa, Hiroshi; Zhou, Yalu; Aoi, Yuki; Fain, Margaret E; Kaminski, Dorian S; Kong, Hyewon; Sebo, Zachary L; Chakrabarty, Ram P; Howard, Benjamin C; Andersen, Grant; Marcheva, Biliana; Gao, Peng; Kapitsinou, Pinelopi; Bass, Joseph; Shilatifard, Ali; Chandel, Navdeep S; Quaggin, Susan E