日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tumor cell-directed STING agonist antibody-drug conjugates induce type III interferons and anti-tumor innate immune responses

靶向肿瘤细胞的STING激动剂抗体药物偶联物可诱导III型干扰素和抗肿瘤先天免疫反应。

Naniye Malli Cetinbas ,Travis Monnell ,Jahna Soomer-James ,Pamela Shaw ,Kelly Lancaster ,Kalli C Catcott ,Melissa Dolan ,Rebecca Mosher ,Caitlin Routhier ,Chen-Ni Chin ,Dorin Toader ,Jeremy Duvall ,Raghida Bukhalid ,Timothy B Lowinger ,Marc Damelin

Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates

发现并优化 STING 激动剂平台以应用于抗体药物偶联物

Jeremy R Duvall, Joshua D Thomas, Raghida A Bukhalid, Kalli C Catcott, Keith W Bentley, Scott D Collins, Timothy Eitas, Brian D Jones, Eugene W Kelleher, Kelly Lancaster, Marina Protopopova, Soumya S Ray, Elena Ter-Ovanesyan, Ling Xu, Liping Yang, Jeffrey Zurita, Marc Damelin, Dorin Toader, Timothy

Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody-Drug Conjugate for the Treatment of Cancer

XMT-1660 的发现和临床前表征:一种用于治疗癌症的优化 B7-H4 靶向抗体-药物偶联物

Dorin Toader ,Shawn P Fessler ,Scott D Collins ,Patrick R Conlon ,Reddy Bollu ,Kalli C Catcott ,Chen-Ni Chin ,Anouk Dirksen ,Bingfan Du ,Jeremy R Duvall ,Stacy Higgins ,Mariya V Kozytska ,Kamela Bellovoda ,Chelsey Faircloth ,David Lee ,Fu Li ,Liuliang Qin ,Caitlin Routhier ,Pamela Shaw ,Cheri A Stevenson ,Jason Wang ,Phonphimon Wongthida ,Elena Ter-Ovanesyan ,Elizabeth Ditty ,Stephen P Bradley ,Ling Xu ,Mao Yin ,Alexandr V Yurkovetskiy ,Rebecca Mosher ,Marc Damelin ,Timothy B Lowinger

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy

双互补位 HER2 靶向抗体-药物偶联物可诱导对 HER2 靶向治疗有耐药性或不适合 HER2 靶向治疗的原发性模型中的肿瘤消退

John Y Li, Samuel R Perry, Vanessa Muniz-Medina, Xinzhong Wang, Leslie K Wetzel, Marlon C Rebelatto, Mary Jane Masson Hinrichs, Binyam Z Bezabeh, Ryan L Fleming, Nazzareno Dimasi, Hui Feng, Dorin Toader, Andy Q Yuan, Lan Xu, Jia Lin, Changshou Gao, Herren Wu, Rakesh Dixit, Jane K Osbourn, Steven R C