日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Network-based allosteric analysis of galectin-7: Key residues dictate functional communication and stability

基于网络的半乳糖凝集素-7变构分析:关键残基决定功能通讯和稳定性

Pham, N T Hang; Paré, Alex; Létourneau, Myriam; Fortier, Marlène; Chatenet, David; St-Pierre, Yves; Lagüe, Patrick; Calmettes, Charles; Doucet, Nicolas

Exposome variations affect Drosophila bristle patterning via the regulation of proneural genes through distinct mechanisms

暴露组变异通过不同的机制调控神经前体基因,从而影响果蝇刚毛的模式形成。

Ribeiro, Valérie; Doucet, Nicolas; Gho, Michel; Audibert, Agnès; Gibert, Jean-Michel

Development and Use of a Galectin-1-Specific Nanobody for Tumor Imaging and Elucidating the Role of Galectin‑1 in Cancer

开发和应用半乳糖凝集素-1特异性纳米抗体进行肿瘤成像,并阐明半乳糖凝集素-1在癌症中的作用

Granger Joly de Boissel, Philippine; Nehmé, Rita; Fortier, Marlène; Létourneau, Myriam; Guérin, Brigitte; Dumulon-Perreault, Véronique; Ait-Mohand, Samia; Sarrhini, Otman; Fuselier, Camille; Dumoulin, Alyssa; Chatenet, David; Doucet, Nicolas; St-Pierre, Yves

Ancestral sequence reconstruction dissects structural and functional differences among eosinophil ribonucleases

祖先序列重建揭示嗜酸性粒细胞核糖核酸酶的结构和功能差异

Tran, Thi Thanh Quynh; Narayanan, Chitra; Loes, Andrea N; Click, Timothy H; Pham, N T Hang; Létourneau, Myriam; Harms, Michael J; Calmettes, Charles; Agarwal, Pratul K; Doucet, Nicolas

A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype

多种假定蛋白质中保守的SH3样折叠结构可四聚化形成氧化还原酶,从而赋予其抗菌耐药表型。

Lemay-St-Denis, Claudèle; Alejaldre, Lorea; Jemouai, Zakaria; Lafontaine, Kiana; St-Aubin, Maxime; Hitache, Katia; Valikhani, Donya; Weerasinghe, Nuwani W; Létourneau, Myriam; Thibodeaux, Christopher J; Doucet, Nicolas; Baron, Christian; Copp, Janine N; Pelletier, Joelle N

Conformational exchange divergence along the evolutionary pathway of eosinophil-associated ribonucleases

嗜酸性粒细胞相关核糖核酸酶进化路径上的构象交换差异

Bernard, David N; Narayanan, Chitra; Hempel, Tim; Bafna, Khushboo; Bhojane, Purva Prashant; Létourneau, Myriam; Howell, Elizabeth E; Agarwal, Pratul K; Doucet, Nicolas

Protein context shapes the specificity of SH3 domain-mediated interactions in vivo

蛋白质环境决定体内 SH3 结构域介导相互作用的特异性

Ugo Dionne, Émilie Bourgault #, Alexandre K Dubé #, David Bradley #, François J M Chartier #, Rohan Dandage, Soham Dibyachintan, Philippe C Després, Gerald D Gish, N T Hang Pham, Myriam Létourneau, Jean-Philippe Lambert, Nicolas Doucet, Nicolas Bisson, Christian R Landry0

Enzyme dynamics: Looking beyond a single structure

酶动力学:超越单一结构

Agarwal, Pratul K; Bernard, David N; Bafna, Khushboo; Doucet, Nicolas

Prevalence and mechanisms of azole resistance in clinical isolates of Aspergillus section Fumigati species in a Canadian tertiary care centre, 2000 to 2013

2000年至2013年加拿大一家三级医疗中心临床分离的烟曲霉属真菌对唑类药物耐药性的流行情况及机制

Parent-Michaud, Maxime; Dufresne, Philippe J; Fournier, Eric; Folch, Benjamin; Martineau, Christine; Moreira, Sandrine; Doucet, Nicolas; De Repentigny, Louis; Dufresne, Simon F

The Structural Dynamics of Engineered β-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function

工程化β-内酰胺酶的结构动力学在三个时间尺度上变化显著,但仍能维持其天然功能。

Gobeil, Sophie M C; Ebert, Maximillian C C J C; Park, Jaeok; Gagné, Donald; Doucet, Nicolas; Berghuis, Albert M; Pleiss, Jürgen; Pelletier, Joelle N