日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

LILRB2 blockade facilitates macrophage repolarization and enhances T cell-mediated antitumor immunity

LILRB2阻断可促进巨噬细胞重极化并增强T细胞介导的抗肿瘤免疫

Jones, Des C; Irving, Lorraine; Dudley, Rebecca; Blümli, Seraina; Wolny, Marcin; Chatzopoulou, Elisavet I; Pryts, Stacy; Ahuja, Shreya; Rees, D Gareth; Sandercock, Alan M; Rajan, Saravanan; Varkey, Reena; Kierny, Michael; Kayserian, Andrew; Mulgrew, Kathy; Bowyer, Georgina; Songvilay, Saly; Bienkowska, Kamila; Glover, Matthew S; Hess, Sonja; Dovedi, Simon J; Wilkinson, Robert W; Arnaldez, Fernanda; Cobbold, Mark

An affinity-modulated T cell engager targeting Claudin 18.2 shows potent anti-tumor activity with limited cytokine release

一种靶向 Claudin 18.2 的亲和力调节型 T 细胞衔接器显示出强大的抗肿瘤活性,且细胞因子释放有限

Miguel Gaspar # ,Marina Natoli # ,Laure Castan ,Sharif Rahmy ,Martin Korade 3rd ,Cathryn Kelton ,Kathy Mulgrew ,Oisin Huhn ,D Gareth Rees ,Anna Sigurdardottir ,Christopher Lloyd ,Jonathan J Taylor ,Phillip M Brailey ,Laura Dallaway ,Aleksandra Toloczko ,Nicolas Giraldo ,Maria A S Broggi ,Andrew Kunihiro ,Sudhanshu Abhishek ,Yun He ,Yiping Rong ,Jim Eyles ,Kathryn Ball ,Jonathan Fitzgerald ,Scott A Hammond ,Saso Cemerski ,Simon J Dovedi ,Mark Cobbold

In Vivo Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade

体内标记解析了肿瘤巨噬细胞不同的时间、空间和功能特性,并识别了PD-L1阻断的亚群特异性效应

Colin Y C Lee,Isaac Dean,Nathan Richoz,Zhi Li,Bethany C Kennedy,Lisa A Vettore,Youhani Samarakoon,Kathryn L Gilroy,Tetsuo Hasegawa,Gianluca Carlesso,Scott A Hammond,Simon J Dovedi,Owen J Sansom,Zewen K Tuong,Timotheus Y F Halim,David R Withers,Menna R Clatworthy

Innovative strategies for T cell engagers for cancer immunotherapy

用于癌症免疫治疗的T细胞衔接器的创新策略

Bergamaschi, Cristina; Gaspar, Miguel; Ciucci, Thomas; Sitnikova, Suzanne I; Cayatte, Corinne; Pica, Mike; Dovedi, Simon J

A comprehensive welfare scoring system for graft versus host disease clinical assessment in humanised mouse models used for pharmaceutical research

用于药物研发的人源化小鼠模型中移植物抗宿主病临床评估的综合福利评分系统

Nowak, Alice; Marlow, Rebecca; Ryan, Kelli; Lapointe, Jean-Martin; Sutton, Daniel; Sharpe, Alan; Crook, Lucy; Walker, Jennifer A; Little, Emma; Peverill, John; Holberry-Brown, Adam; Wassell, Emma; McLaren-Jones, Robbie; Cavanagh, Chelsea; Dobre, Alex Vlad; Baker, Tamara; Clayton, Matthew; Karp, Natasha A; Plugge, Michiel; Thomas, Aurélie A; Dovedi, Simon J; Sitnikova, Suzanne I; Burrows, Natalie

Characterisation of human in vitro tumour-associated macrophage models to define translational relevance

对人源体外肿瘤相关巨噬细胞模型进行表征,以确定其转化相关性

Dyer, Arthur; Dudley, Rebecca; Ahuja, Shreya; Alsinet, Clara; Poudel, Pawan; Bowyer, Georgina; Sahota, Kalvin; Songvilay, Saly; Jones, Des C; Glover, Matthew; Hess, Sonja; Timosenko, Elina; Dovedi, Simon J

Chasing clues : Dementia unveils PML long after R‐CHOP treatment

追寻线索:痴呆症在R-CHOP治疗后很久才揭示PML

Oguejiofor, Kenneth; Galletta-Williams, Henry; Dovedi, Simon J; Roberts, Darren L; Stern, Peter L; West, Catharine M L; T, Swathi Sr; Swathi, Thamil Pavai

Tumour-retained activated CCR7+ dendritic cells are heterogeneous and regulate local anti-tumour cytolytic activity

肿瘤中保留的活化 CCR7+ 树突状细胞是异质性的,可调节局部抗肿瘤细胞溶解活性

Colin Y C Lee, Bethany C Kennedy, Nathan Richoz, Isaac Dean, Zewen K Tuong, Fabrina Gaspal, Zhi Li, Claire Willis, Tetsuo Hasegawa, Sarah K Whiteside, David A Posner, Gianluca Carlesso, Scott A Hammond, Simon J Dovedi, Rahul Roychoudhuri, David R Withers, Menna R Clatworthy

Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity

肿瘤侵入后,自然杀伤细胞功能迅速受损,限制了抗肿瘤免疫力。

Isaac Dean ,Colin Y C Lee ,Zewen K Tuong ,Zhi Li ,Christopher A Tibbitt ,Claire Willis ,Fabrina Gaspal ,Bethany C Kennedy ,Veronika Matei-Rascu ,Rémi Fiancette ,Caroline Nordenvall ,Ulrik Lindforss ,Syed Murtuza Baker ,Christian Stockmann ,Veronika Sexl ,Scott A Hammond ,Simon J Dovedi ,Jenny Mjösberg ,Matthew R Hepworth ,Gianluca Carlesso ,Menna R Clatworthy ,David R Withers

Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80/PD-L1 interaction.

CTLA-4 与 CD80 的刚性二价结合是破坏顺式 CD80/PD-L1 相互作用所必需的。

Robinson Maximillian A, Kennedy Alan, Orozco Carolina T, Chen Hung-Chang, Waters Erin, Giovacchini Dalisay, Yeung Kay, Filer Lily, Hinze Claudia, Lloyd Christopher, Dovedi Simon J, Sansom David M