日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH)

疟原虫体内前药的激活是由一种输入的红细胞酯酶——酰基肽水解酶(APEH)介导的。

Sundararaman, Sesh A; Miller, Justin J; Daley, Ellora C; O'Brien, Kelsey A; Kasak, Paulina; Daniels, Abigail M; Edwards, Rachel L; Heidel, Kenneth M; Bague, Darean A; Wilson, Madeleine A; Koelper, Andrew J; Kourtoglou, Elexi C; White, Alex D; August, Sloan A; Apple, Georgia A; Rouamba, Regis W; Durand, Anthony J; Esteb, John J; Muller, Florian L; Johnson, R Jeremy; Hoops, Geoffrey C; Dowd, Cynthia S; Odom John, Audrey R

Phosphoryl Prodrugs: Characteristics to Improve Drug Development

磷酰前药:有助于改善药物研发的特性

Kirby, Samuel A; Dowd, Cynthia S

Correction: Structure-guided microbial targeting of antistaphylococcal prodrugs

更正:抗葡萄球菌前药的结构导向微生物靶向治疗

Miller, Justin J; Shah, Ishaan T; Hatten, Jayda; Barekatain, Yasaman; Mueller, Elizabeth A; Moustafa, Ahmed M; Edwards, Rachel L; Dowd, Cynthia S; Hoops, Geoffrey C; Johnson, R Jeremy; Planet, Paul; Muller, Florian L; Jez, Joseph; Odom John, Audrey R

Potent, specific MEPicides for treatment of zoonotic staphylococci

用于治疗人畜共患葡萄球菌感染的强效、特异性MEPicides

Edwards, Rachel L; Heueck, Isabel; Lee, Soon Goo; Shah, Ishaan T; Miller, Justin J; Jezewski, Andrew J; Mikati, Marwa O; Wang, Xu; Brothers, Robert C; Heidel, Kenneth M; Osbourn, Damon M; Burnham, Carey-Ann D; Alvarez, Sophie; Fritz, Stephanie A; Dowd, Cynthia S; Jez, Joseph M; Odom John, Audrey R

Vitamin in the Crosshairs: Targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents

维生素成为研究热点:靶向泛酸和辅酶A生物合成开发新型抗结核药物

Butman, Hailey S; Kotzé, Timothy J; Dowd, Cynthia S; Strauss, Erick

Antimicrobial Prodrug Activation by the Staphylococcal Glyoxalase GloB.

葡萄球菌乙二醛酶 GloB 对抗菌前药的激活作用

Mikati Marwa O, Miller Justin J, Osbourn Damon M, Barekatain Yasaman, Ghebremichael Naomi, Shah Ishaan T, Burnham Carey-Ann D, Heidel Kenneth M, Yan Victoria C, Muller Florian L, Dowd Cynthia S, Edwards Rachel L, Odom John Audrey R

Phosphonate prodrugs: an overview and recent advances

膦酸酯前药:概述及最新进展

Heidel, Kenneth M; Dowd, Cynthia S

MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria

MEPicides:α,β-不饱和磷霉素类似物作为抗疟疾的DXR抑制剂

Wang, Xu; Edwards, Rachel L; Ball, Haley; Johnson, Claire; Haymond, Amanda; Girma, Misgina; Manikkam, Michelle; Brothers, Robert C; McKay, Kyle T; Arnett, Stacy D; Osbourn, Damon M; Alvarez, Sophie; Boshoff, Helena I; Meyers, Marvin J; Couch, Robin D; Odom John, Audrey R; Dowd, Cynthia S

MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis

MEPicides:靶向异戊二烯生物合成的强效抗疟前药

Edwards, Rachel L; Brothers, Robert C; Wang, Xu; Maron, Maxim I; Ziniel, Peter D; Tsang, Patricia S; Kraft, Thomas E; Hruz, Paul W; Williamson, Kim C; Dowd, Cynthia S; John, Audrey R Odom

Design, synthesis, and evaluation of substituted nicotinamide adenine dinucleotide (NAD(+)) synthetase inhibitors as potential antitubercular agents

设计、合成和评价取代型烟酰胺腺嘌呤二核苷酸(NAD(+))合成酶抑制剂作为潜在的抗结核药物

Wang, Xu; Ahn, Yong-Mo; Lentscher, Adam G; Lister, Julia S; Brothers, Robert C; Kneen, Malea M; Gerratana, Barbara; Boshoff, Helena I; Dowd, Cynthia S