日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GLP-1R biased cAMP agonism maintains glycemic control with reduced malaise and emesis in preclinical mammalian models

在临床前哺乳动物模型中,GLP-1R 偏向性 cAMP 激动剂作用可维持血糖控制,并减少不适和呕吐。

Baumer-Harrison, Caitlin; Aldaghma, Danya; White, Alex D; Applebey, Sarah V; Pataro, Allison M; Mohiby, Allaha Z; Alonso, Brandon; Xiao, Allison G; O'Farrell, Libbey S; Qian, Yuewei; Coskun, Tamer; Coghlan, Matthew P; Willard, Francis S; Ai, Minrong; Sloop, Kyle W; Doyle, Robert P; Borner, Tito; De Jonghe, Bart C; Hayes, Matthew R

Therapeutic potential for glial-derived octadecaneuropeptide in the treatment of obesity

神经胶质细胞衍生十八肽在肥胖症治疗中的治疗潜力

Orativskyi, Oleksandr; Geisler, Caroline E; Hayes, Matthew R; Doyle, Robert P

Hindbrain octadecaneuropeptide gliotransmission as a therapeutic target for energy balance control without nausea or emesis

后脑十八肽神经胶质传递作为能量平衡控制的治疗靶点,不引起恶心或呕吐

Geisler, Caroline E; Chichura, Kylie S; Orativskyi, Oleksandr; Hu, Jiayin; Belser, Drew L; Pelletier, Caitlyn M; Borner, Tito; Baumer-Harrison, Caitlin; De Jonghe, Bart C; Crist, Richard C; Reiner, Benjamin C; Doyle, Robert P; Hayes, Matthew R

Vagal oxytocin receptors are necessary for esophageal motility and function.

迷走神经催产素受体对食管动力和功能是必需的

Asker Mohammed, Krieger Jean-Philippe, Maric Ivana, Bedel Emre, Steen Jenny, Börchers Stina, Wen Yuxiang, Longo Francesco, Aronsson Patrik, Winder Michael, Doyle Robert P, Hayes Matthew R, Skibicka Karolina P

Corrin Ring Modification in Peptide Drug Development - a Brief History of "Corrination"

肽类药物开发中的咕啉环修饰——“咕啉化”简史

Cham, Nancy; Doyle, Robert P

Sex differences in central endozepine expression and regulation of appetite.

中枢内源性苯二酚表达和食欲调节的性别差异

Geisler Caroline E, Applebey Sarah V, Chichura Kylie S, Pelletier Caitlyn M, Belser Drew L, Hu Jiayin, Harris Erin P, Levine Caleb M, Parent Marise B, Bangasser Debra A, Doyle Robert P, Hayes Matthew R

Reductions of food intake and body weight in diet-induced obese rats following chronic treatment with a monomeric peptide multiagonist

长期使用单体肽多激动剂治疗后,饮食诱导肥胖大鼠的食物摄入量和体重均有所降低

Elfers, Clinton T; Chichura, Kylie S; Ashlaw, Emily F; Chepurny, Oleg G; Holz, George G; Doyle, Robert P; Roth, Christian L

The novel chimeric multi-agonist peptide (GEP44) reduces energy intake and body weight in male and female diet-induced obese mice in a glucagon-like peptide-1 receptor-dependent manner

新型嵌合多激动剂肽(GEP44)以胰高血糖素样肽-1受体依赖的方式降低饮食诱导肥胖的雄性和雌性小鼠的能量摄入和体重。

Blevins, James E; Honeycutt, Mackenzie K; Slattery, Jared D; Goldberg, Matvey; Rambousek, June R; Tsui, Edison; Dodson, Andrew D; Shelton, Kyra A; Salemeh, Therese S; Elfers, Clinton T; Chichura, Kylie S; Ashlaw, Emily F; Zraika, Sakeneh; Doyle, Robert P; Roth, Christian L

Corrination mitigates peptide aggregation as exemplified for Glucagon

配体作用可减轻肽的聚集,例如胰高血糖素。

Liles, Amber; Cham, Nancy; Opp, Morgan L; Tinsley, Ian C; Chepurny, Oleg G; Holz, George G; Doyle, Robert P

A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss

GLP-1、神经肽Y1和神经肽Y2受体的三重激动肽可促进血糖控制和体重减轻

Chichura, Kylie S; Elfers, Clinton T; Salameh, Therese S; Kamat, Varun; Chepurny, Oleg G; McGivney, Aelish; Milliken, Brandon T; Holz, George G; Applebey, Sarah V; Hayes, Matthew R; Sweet, Ian R; Roth, Christian L; Doyle, Robert P