Drag Marcin相关文献与解析，生知库 | 链接生命科学的每一步

Makhaik, Sparsh; Rut, Wioletta; Choudhary, Shruti; Upadhyay, Tulsi; Hao, Chenzhou; Westberg, Michael; Bobst, Cedric; Yoo, Euna; Fejzo, Jasna; Lin, Michael Z; Bogyo, Matthew; Thompson, Paul; Drag, Marcin; Hardy, Jeanne A

微生物学

发表日期：2025

文献求助收藏

Identification and Exploration of a Series of SARS-Cov‑2 M(Pro) Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group

鉴定和探索一系列SARS-CoV-2 M(Pro)氰基抑制剂，揭示P3联苯基团中的邻位取代效应

期刊:ACS Medicinal Chemistry Letters

影响因子:4

doi:10.1021/acsmedchemlett.5c00301

Clyde-Allen, Emma; Zmudzinski, Mikołaj; Afsar, Mohammad; James, Ciyana; Nayak, Anindita; Nayak, Digant; Dos Santos Bury, Priscila; Jochmans, Dirk; Neyts, Johann; Scott, Christopher J; Olsen, Shaun K; Drag, Marcin; Williams, Rich

SARS-CoV-2

发表日期：2025

文献求助收藏

A Robust Fluorogenic Substrate for Chikungunya Virus Protease (nsP2) Activity

一种用于检测基孔肯雅病毒蛋白酶 (nsP2) 活性的强效荧光底物

期刊:

影响因子:

doi:10.1101/2025.02.01.636040

微生物学

发表日期：2025

文献求助收藏

Profiling of coronaviral M(pro) and enteroviral 3C(pro) specificity provides a framework for the development of broad-spectrum antiviral compounds

对冠状病毒M蛋白和肠道病毒3C蛋白特异性的分析为开发广谱抗病毒化合物提供了框架。

期刊:Protein Science

影响因子:5.2

doi:10.1002/pro.5139

Rut, Wioletta; Groborz, Katarzyna; Sun, Xinyuanyuan; Hilgenfeld, Rolf; Drag, Marcin

微生物学

发表日期：2024

文献求助收藏

Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin.

利用蛋白酶底物特异性筛选合理设计含非天然氨基酸的选择性蛋白酶抑制剂：应用于 HGFA、matriptase 和 hepsin

期刊:Protein Science

影响因子:5.2

doi:10.1002/pro.5110

Mahoney Matthew W, Helander Jonathan, Kooner Anoopjit S, Norman Mariah, Damalanka Vishnu C, De Bona Paolo, Kasperkiewicz Paulina, Rut Wioletta, Poreba Marcin, Kashipathy Maithri M, Battaile Kevin P, Lovell Scott, O'Donoghue Anthony J, Craik Charles S, Drag Marcin, Janetka James W

其它

发表日期：2024

文献求助收藏

Targeting Microglial Immunoproteasome: A Novel Approach in Neuroinflammatory-Related Disorders

靶向小胶质细胞免疫蛋白酶体：神经炎症相关疾病的新方法

期刊:ACS Chemical Neuroscience

影响因子:3.9

doi:10.1021/acschemneuro.4c00099

Malek, Natalia; Gladysz, Radoslaw; Stelmach, Natalia; Drag, Marcin

SARS-CoV-2 M(pro) Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals

值得关注的SARS-CoV-2 M(pro)蛋白酶变体表现出病毒底物和细胞宿主靶标半乳糖凝集素-8加工的改变，但仍对抗菌药物敏感

期刊:ACS Central Science

影响因子:10.4

doi:10.1021/acscentsci.3c00054

Chen, Sizhu Amelia; Arutyunova, Elena; Lu, Jimmy; Khan, Muhammad Bashir; Rut, Wioletta; Zmudzinski, Mikolaj; Shahbaz, Shima; Iyyathurai, Jegan; Moussa, Eman W; Turner, Zoe; Bai, Bing; Lamer, Tess; Nieman, James A; Vederas, John C; Julien, Olivier; Drag, Marcin; Elahi, Shokrollah; Young, Howard S; Lemieux, M Joanne

Amino acid variants of SARS-CoV-2 papain-like protease have impact on drug binding

SARS-CoV-2木瓜蛋白酶样蛋白酶的氨基酸变体对药物结合有影响

期刊:PLoS Computational Biology

影响因子:3.6

doi:10.1371/journal.pcbi.1010667

Perlinska, Agata P; Stasiulewicz, Adam; Nguyen, Mai Lan; Swiderska, Karolina; Zmudzinski, Mikolaj; Maksymiuk, Alicja W; Drag, Marcin; Sulkowska, Joanna I

SARS-CoV-2

发表日期：2022

文献求助收藏

Reynoutria Rhizomes as a Natural Source of SARS-CoV-2 Mpro Inhibitors-Molecular Docking and In Vitro Study

雷诺特里亚根茎作为SARS-CoV-2 Mpro抑制剂的天然来源——分子对接和体外研究

期刊:Pharmaceuticals

影响因子:4.8

doi:10.3390/ph14080742

Nawrot-Hadzik, Izabela; Zmudzinski, Mikolaj; Matkowski, Adam; Preissner, Robert; Kęsik-Brodacka, Małgorzata; Hadzik, Jakub; Drag, Marcin; Abel, Renata

SARS-CoV-2

发表日期：2021

文献求助收藏

Design of Optical-Imaging Probes by Screening of Diverse Substrate Libraries Directly in Disease-Tissue Extracts

通过直接在疾病组织提取物中筛选多种底物库来设计光学成像探针

期刊:Angewandte Chemie-International Edition

影响因子:16.9

doi:10.1002/anie.202006719

Tholen, Martina; Yim, Joshua J; Groborz, Katarzyna; Yoo, Euna; Martin, Brock A; van den Berg, Nynke S; Drag, Marcin; Bogyo, Matthew

发表日期：2020

文献求助收藏

A robust fluorogenic substrate for chikungunya virus protease (nsP2) activity

一种用于检测基孔肯雅病毒蛋白酶（nsP2）活性的强效荧光底物

Identification and Exploration of a Series of SARS-Cov‑2 M(Pro) Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group

鉴定和探索一系列SARS-CoV-2 M(Pro)氰基抑制剂，揭示P3联苯基团中的邻位取代效应

A Robust Fluorogenic Substrate for Chikungunya Virus Protease (nsP2) Activity

一种用于检测基孔肯雅病毒蛋白酶 (nsP2) 活性的强效荧光底物

Profiling of coronaviral M(pro) and enteroviral 3C(pro) specificity provides a framework for the development of broad-spectrum antiviral compounds

对冠状病毒M蛋白和肠道病毒3C蛋白特异性的分析为开发广谱抗病毒化合物提供了框架。

Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin.

利用蛋白酶底物特异性筛选合理设计含非天然氨基酸的选择性蛋白酶抑制剂：应用于 HGFA、matriptase 和 hepsin

Targeting Microglial Immunoproteasome: A Novel Approach in Neuroinflammatory-Related Disorders

靶向小胶质细胞免疫蛋白酶体：神经炎症相关疾病的新方法

SARS-CoV-2 M(pro) Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals

值得关注的SARS-CoV-2 M(pro)蛋白酶变体表现出病毒底物和细胞宿主靶标半乳糖凝集素-8加工的改变，但仍对抗菌药物敏感

Amino acid variants of SARS-CoV-2 papain-like protease have impact on drug binding

SARS-CoV-2木瓜蛋白酶样蛋白酶的氨基酸变体对药物结合有影响

Reynoutria Rhizomes as a Natural Source of SARS-CoV-2 Mpro Inhibitors-Molecular Docking and In Vitro Study

雷诺特里亚根茎作为SARS-CoV-2 Mpro抑制剂的天然来源——分子对接和体外研究

Design of Optical-Imaging Probes by Screening of Diverse Substrate Libraries Directly in Disease-Tissue Extracts

通过直接在疾病组织提取物中筛选多种底物库来设计光学成像探针