Drotar Denise M相关文献与解析，生知库 | 链接生命科学的每一步

Becker, Matthew W; Brown, Matthew E; Wiseman, Katherine; Chiodetti, Ana Laura; Huber, Mollie K; Cuaycal, Alexandra E; Sintara, Pumin; Ferreira, Sandra M; Smurlick, Dylan; Barra, Jessie M; Ladd, Andrew M; Drotar, Denise M; Atkinson, Mark A; Weber, Peter; Al-Mossawi, Hussein; Russ, Holger A; Mahon, Tara M; Brusko, Todd M; Bossi, Giovanna; Phelps, Edward A

细胞生物学

PD-1

免疫/内分泌

发表日期：2026

文献求助收藏

Loss of Insulin-Positive Cell Clusters Precedes the Decrease in Islet Frequency and β-Cell Area in Type 1 Diabetes

1型糖尿病中，胰岛素阳性细胞簇的丢失先于胰岛细胞数量和β细胞面积的减少。

期刊:Diabetes

影响因子:7.5

doi:10.2337/db25-0326

Drotar, Denise M; Vazquez Ramos, Giovanni J A; Williams, MacKenzie D; David, Surya T; Luce, Caitlyn; Smith, Justin A; Posgai, Amanda L; Bacher, Rhonda; Campbell-Thompson, Martha; Kusmartseva, Irina; Brusko, Maigan A; Atkinson, Mark A; Wasserfall, Clive H

Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices

胰腺组织切片中β细胞靶向PD-1激动剂对1型糖尿病细胞介导免疫的抑制作用

期刊:

影响因子:

doi:10.1101/2025.10.21.683528

Becker, Matthew W; Brown, Matthew; Wiseman, Katherine; Chiodetti, Ana Laura; Huber, Mollie K; Cuaycal, Alexandra E; Sintara, Pumin; Ferreira, Sandra M; Smurlick, Dylan; Barra, Jessie M; Ladd, Andrew M; Drotar, Denise M; Atkinson, Mark A; Weber, Peter; Al-Mossawi, Hussein; Russ, Holger A; Mahon, Tara M; Brusko, Todd M; Bossi, Giovanna; Phelps, Edward A

Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis

弥合差距：利用器官和组织捐献者的胰腺组织切片研究糖尿病发病机制

期刊:Diabetes

影响因子:7.5

doi:10.2337/dbi20-0018

Cohrs, Christian M; Chen, Chunguang; Atkinson, Mark A; Drotar, Denise M; Speier, Stephan

Impaired islet function and normal exocrine enzyme secretion occur with low inter-regional variation in type 1 diabetes.

1 型糖尿病患者胰岛功能受损，但外分泌酶分泌正常，且区域间差异较小

期刊:Cell Reports

影响因子:6.9

doi:10.1016/j.celrep.2024.114346

Drotar Denise M, Mojica-Avila Ana Karen, Bloss Drew T, Cohrs Christian M, Manson Cameron T, Posgai Amanda L, Williams MacKenzie D, Brusko Maigan A, Phelps Edward A, Wasserfall Clive H, Speier Stephan, Atkinson Mark A

Impaired islet function with normal exocrine enzyme secretion is consistent across the head, body, and tail pancreas regions in type 1 diabetes

1型糖尿病患者的胰岛功能受损，但外分泌酶分泌正常，这种现象在胰腺的头部、体部和尾部均一致。

期刊:

影响因子:

doi:10.1101/2024.02.08.579175

Drotar, Denise M; Mojica-Avila, Ana Karen; Bloss, Drew T; Cohrs, Christian M; Manson, Cameron T; Posgai, Amanda L; Williams, MacKenzie D; Brusko, Maigan A; Phelps, Edward A; Wasserfall, Clive H; Speier, Stephan; Atkinson, Mark A

Beta cell-targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices

靶向β细胞的PD-1激动剂抑制胰腺组织切片中的细胞介导的自身免疫

Loss of Insulin-Positive Cell Clusters Precedes the Decrease in Islet Frequency and β-Cell Area in Type 1 Diabetes

1型糖尿病中，胰岛素阳性细胞簇的丢失先于胰岛细胞数量和β细胞面积的减少。

Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices

胰腺组织切片中β细胞靶向PD-1激动剂对1型糖尿病细胞介导免疫的抑制作用

Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis

弥合差距：利用器官和组织捐献者的胰腺组织切片研究糖尿病发病机制

Impaired islet function and normal exocrine enzyme secretion occur with low inter-regional variation in type 1 diabetes.

1 型糖尿病患者胰岛功能受损，但外分泌酶分泌正常，且区域间差异较小

Impaired islet function with normal exocrine enzyme secretion is consistent across the head, body, and tail pancreas regions in type 1 diabetes

1型糖尿病患者的胰岛功能受损，但外分泌酶分泌正常，这种现象在胰腺的头部、体部和尾部均一致。