日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of CNS tropic AAV1-like variants with reduced liver-targeting following systemic administration in mice

在小鼠体内系统给药后,中枢神经系统嗜性 AAV1 样变体的产生及其肝脏靶向性的降低

Matthieu Drouyer, Jessica Merjane, Deborah Nazareth, Maddison Knight, Suzanne Scott, Sophia H Y Liao, Samantha L Ginn, Erhua Zhu, Ian E Alexander, Leszek Lisowski

Enhanced AAV transduction across preclinical CNS models: A comparative study in human brain organoids with cross-species evaluations

增强 AAV 在临床前 CNS 模型中的转导:对人类脑类器官进行跨物种评估的比较研究

Matthieu Drouyer, Jessica Merjane, Teodora Nedelkoska, Adrian Westhaus, Suzanne Scott, Scott Lee, Peter G R Burke, Simon McMullan, Jose L Lanciego, Ana F Vicente, Ricardo Bugallo, Carmen Unzu, Gloria González-Aseguinolaza, Anai Gonzalez-Cordero, Leszek Lisowski

Novel AAV variants with improved tropism for human Schwann cells

对人类施万细胞具有更好趋向性的新型 AAV 变体

Matthieu Drouyer, Tak-Ho Chu, Elodie Labit, Florencia Haase, Renina Gale Navarro, Deborah Nazareth, Nicole Rosin, Jessica Merjane, Suzanne Scott, Marti Cabanes-Creus, Adrian Westhaus, Erhua Zhu, Rajiv Midha, Ian E Alexander, Jeff Biernaskie, Samantha L Ginn, Leszek Lisowski

PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation

PAK6 介导的 PPP2R2C 磷酸化调节 LRRK2-PP2A 复合物的形成

Lucia Iannotta, Marco Emanuele, Giulia Favetta, Giulia Tombesi, Laurine Vandewynckel, Antonio Jesús Lara Ordóñez, Jean-Michel Saliou, Matthieu Drouyer, William Sibran, Laura Civiero, R Jeremy Nichols, Panagiotis S Athanasopoulos, Arjan Kortholt, Marie-Christine Chartier-Harlin, Elisa Greggio, Jean-M

Clinical relevance of circulating ESR1 mutations during endocrine therapy for advanced hormone-dependent endometrial carcinoma

循环ESR1突变在晚期激素依赖性子宫内膜癌内分泌治疗中的临床意义

Drouyer, Aurélien; Beaussire, Ludivine; Jorda, Pauline; Leheurteur, Marianne; Guillemet, Cécile; Berghian, Anca; Georgescu, Dragos; Di Fiore, Frédéric; Perdrix, Anne; Clatot, Florian

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

LRRK2磷酸化位点突变方法将磷酸化和去磷酸化分别与保护性和有害性标记联系起来

Marchand, Antoine; Sarchione, Alessia; Athanasopoulos, Panagiotis S; Roy, Hélène Bauderlique-Le; Goveas, Liesel; Magnez, Romain; Drouyer, Matthieu; Emanuele, Marco; Ho, Franz Y; Liberelle, Maxime; Melnyk, Patricia; Lebègue, Nicolas; Thuru, Xavier; Nichols, R Jeremy; Greggio, Elisa; Kortholt, Arjan; Galli, Thierry; Chartier-Harlin, Marie-Christine; Taymans, Jean-Marc

Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation

蛋白磷酸酶 2A 全酶调节富含亮氨酸重复激酶 2 磷酸化和积累

Matthieu Drouyer, Marc F Bolliger, Evy Lobbestael, Chris Van den Haute, Marco Emanuele, Réginald Lefebvre, William Sibran, Tina De Wit, Coline Leghay, Eugénie Mutez, Nicolas Dzamko, Glenda M Halliday, Shigeo Murayama, Alain Martoriati, Katia Cailliau, Jean-François Bodart, Marie-Christine Chartier-H

Single amino acid insertion allows functional transduction of murine hepatocytes with human liver tropic AAV capsids

单个氨基酸插入可实现小鼠肝细胞与人类肝脏嗜性 AAV 衣壳的功能转导

Marti Cabanes-Creus, Renina Gale Navarro, Sophia H Y Liao, Grober Baltazar, Matthieu Drouyer, Erhua Zhu, Suzanne Scott, Clement Luong, Laurence O W Wilson, Ian E Alexander, Leszek Lisowski

Novel human liver-tropic AAV variants define transferable domains that markedly enhance the human tropism of AAV7 and AAV8

新型人类肝嗜性 AAV 变体定义了可转移结构域,可显著增强 AAV7 和 AAV8 的人类嗜性

Marti Cabanes-Creus, Renina Gale Navarro, Erhua Zhu, Grober Baltazar, Sophia H Y Liao, Matthieu Drouyer, Anais K Amaya, Suzanne Scott, Loan Hanh Nguyen, Adrian Westhaus, Matthias Hebben, Laurence O W Wilson, Adrian J Thrasher, Ian E Alexander, Leszek Lisowski

Restoring the natural tropism of AAV2 vectors for human liver

恢复 AAV2 载体对人类肝脏的天然趋向性

Marti Cabanes-Creus, Claus V Hallwirth, Adrian Westhaus, Boaz H Ng, Sophia H Y Liao, Erhua Zhu, Renina Gale Navarro, Grober Baltazar, Matthieu Drouyer, Suzanne Scott, Grant J Logan, Giorgia Santilli, Antonette Bennett, Samantha L Ginn, Geoff McCaughan, Adrian J Thrasher, Mavis Agbandje-McKenna, Ian