日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Design, Synthesis, and Biological Evaluation of Novel Acetylcholinesterase and β-Secretase 1 Inhibitors

新型乙酰胆碱酯酶和β-分泌酶1抑制剂的设计、合成及生物学评价

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms27021008
Drozdowska, Danuta; Pawelski, Damian; Wróbel-Tałałaj, Agnieszka; Plonska-Brzezinska, Marta; Kolesinska, Beata; Lazny, Ryszard; Seroka, Barbara; Parzych, Cezary; Ratkiewicz, Artur
发表日期：2026
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Rational design, synthesis, and molecular modelling insights of dual DNA binders/DHFR inhibitors bearing arylidene-hydrazinyl-1,3-thiazole scaffold with apoptotic and anti-migratory potential in breast MCF-7 cancer cells.

对具有亚芳基肼基-1,3-噻唑骨架的双重DNA结合剂/DHFR抑制剂进行合理设计、合成和分子建模，以研究其在乳腺癌MCF-7细胞中的凋亡和抗迁移潜力

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2468353
El-Wakil Marwa H, Ghazala Rasha A, El-Dershaby Hadeel A, Drozdowska Danuta, Wróbel-Tałałaj Agnieszka, Parzych Cezary, Ratkiewicz Artur, Kolesińska Beata, Abd El-Razik Heba A, Soliman Farid S G
细胞生物学
凋亡
发表日期：2025
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Repurposed Arylidene-hydrazinyl-1,3-thiazoles as Multitarget Anti-Alzheimer's Agents via Combined Computational and Experimental Studies

通过计算和实验相结合的研究，将亚芳基肼基-1,3-噻唑类化合物重新用于多靶点抗阿尔茨海默病治疗

期刊:ACS Omega
影响因子:4.3
doi:10.1021/acsomega.5c08737
Drozdowska, Danuta; Ratkiewicz, Artur; Wróbel-Tałałaj, Agnieszka; Parzych, Cezary; El-Dershaby, Hadeel A; Abd El-Razik, Heba A; Soliman, Farid S G; El-Wakil, Marwa H
阿尔茨海默症
发表日期：2025
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Benzamide Trimethoprim Derivatives as Human Dihydrofolate Reductase Inhibitors-Molecular Modeling and In Vitro Activity Study

苯甲酰胺类甲氧苄啶衍生物作为人二氢叶酸还原酶抑制剂——分子建模和体外活性研究

期刊:Biomedicines
影响因子:3.9
doi:10.3390/biomedicines12051079
Drozdowska, Danuta; Wróbel-Tałałaj, Agnieszka; Parzych, Cezary; Ratkiewicz, Artur
Human
发表日期：2024
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Synthesis, Biological Activity, and Molecular Dynamics Study of Novel Series of a Trimethoprim Analogs as Multi-Targeted Compounds: Dihydrofolate Reductase (DHFR) Inhibitors and DNA-Binding Agents

新型甲氧苄啶类似物系列作为多靶点化合物的合成、生物活性和分子动力学研究：二氢叶酸还原酶（DHFR）抑制剂和DNA结合剂

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms22073685
Wróbel, Agnieszka; Baradyn, Maciej; Ratkiewicz, Artur; Drozdowska, Danuta
发表日期：2021
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Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors

甲氧苄啶和其他非经典抗叶酸药物是寻找二氢叶酸还原酶抑制剂修饰剂的绝佳模板。

期刊:Journal of Antibiotics
影响因子:2.7
doi:10.1038/s41429-019-0240-6
Wróbel, Agnieszka; Arciszewska, Karolina; Maliszewski, Dawid; Drozdowska, Danuta
发表日期：2020
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Trimethoprim: An Old Antibacterial Drug as a Template to Search for New Targets. Synthesis, Biological Activity and Molecular Modeling Study of Novel Trimethoprim Analogs

甲氧苄啶：一种老牌抗菌药物作为寻找新靶点的模板。新型甲氧苄啶类似物的合成、生物活性及分子建模研究

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules25010116
Wróbel, Agnieszka; Maliszewski, Dawid; Baradyn, Maciej; Drozdowska, Danuta
发表日期：2019
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The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines

新型三嗪氮芥对胶质母细胞瘤LBC3、LN-18和LN-229细胞系的细胞效应

期刊:Investigational New Drugs
影响因子:2.7
doi:10.1007/s10637-018-0712-8
Krętowski, Rafał; Drozdowska, Danuta; Kolesińska, Beata; Kamiński, Zbigniew; Frączyk, Justyna; Cechowska-Pasko, Marzanna
细胞生物学
发表日期：2019
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