Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD.
在 MASLD 中，SHMT2 活性逆转导致丝氨酸合成，进而引起甘氨酸耗竭和对乙酰氨基酚肝毒性
期刊:Cell Metabolism
影响因子:30.9
doi:10.1016/j.cmet.2023.12.013
Ghrayeb Alia, Finney Alexandra C, Agranovich Bella, Peled Daniel, Anand Sumit Kumar, McKinney M Peyton, Sarji Mahasen, Yang Dongshan, Weissman Natan, Drucker Shani, Fernandes Sara Isabel, Fernández-GarcÃa Jonatan, Mahan Kyle, Abassi Zaid, Tan Lin, Lorenzi Philip L, Traylor James, Zhang Jifeng, Abramovich Ifat, Chen Y Eugene, Rom Oren, Mor Inbal, Gottlieb Eyal
