日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations

利用计算方法设计具有更高开发性的治疗性抗体:高效遍历结合物分布图和挽救逃逸突变

Frédéric A Dreyer ,Constantin Schneider ,Aleksandr Kovaltsuk ,Daniel Cutting ,Matthew J Byrne ,Daniel A Nissley ,Henry Kenlay ,Claire Marks ,David Errington ,Richard J Gildea ,David Damerell ,Pedro Tizei ,Wilawan Bunjobpol ,John F Darby ,Ieva Drulyte ,Daniel L Hurdiss ,Sachin Surade ,Newton Wahome ,Douglas E V Pires ,Charlotte M Deane

Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein

中和抗体揭示猪德尔塔冠状病毒刺突蛋白的隐秘弱点和域间串扰

Wenjuan Du #, Oliver Debski-Antoniak #, Dubravka Drabek, Rien van Haperen, Melissa van Dortmondt, Joline van der Lee, Ieva Drulyte, Frank J M van Kuppeveld, Frank Grosveld, Daniel L Hurdiss, Berend-Jan Bosch

Oral Estrogen Receptor PROTAC Vepdegestrant (ARV-471) Is Highly Efficacious as Monotherapy and in Combination with CDK4/6 or PI3K/mTOR Pathway Inhibitors in Preclinical ER+ Breast Cancer Models

口服雌激素受体 PROTAC Vepdegestrant (ARV-471) 作为单一疗法以及与 CDK4/6 或 PI3K/mTOR 通路抑制剂联合使用在临床前 ER+ 乳腺癌模型中具有高效性

Sheryl M Gough, John J Flanagan, Jessica Teh, Monica Andreoli, Emma Rousseau, Melissa Pannone, Mark Bookbinder, Ryan Willard, Kim Davenport, Elizabeth Bortolon, Gregory Cadelina, Debbie Gordon, Jennifer Pizzano, Jennifer Macaluso, Leofal Soto, John Corradi, Katherine Digianantonio, Ieva Drulyte, Ali

Sialoglycan binding triggers spike opening in a human coronavirus

唾液酸糖结合触发人类冠状病毒刺突蛋白的开放

Pronker, Matti F; Creutznacher, Robert; Drulyte, Ieva; Hulswit, Ruben J G; Li, Zeshi; van Kuppeveld, Frank J M; Snijder, Joost; Lang, Yifei; Bosch, Berend-Jan; Boons, Geert-Jan; Frank, Martin; de Groot, Raoul J; Hurdiss, Daniel L

Direct cell extraction of membrane proteins for structure-function analysis

直接细胞提取膜蛋白用于结构功能分析

Ieva Drulyte #, Aspen Rene Gutgsell #, Pilar Lloris-Garcerá #, Michael Liss, Stefan Geschwindner, Mazdak Radjainia, Jens Frauenfeld, Robin Löving

A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein

SARS-CoV-2 刺突蛋白的广谱大环肽抑制剂

Vito Thijssen, Daniel L Hurdiss, Oliver J Debski-Antoniak, Matthew A Spence, Charlotte Franck, Alexander Norman, Anupriya Aggarwal, Nadia J Mokiem, David A A van Dongen, Stein W Vermeir, Minglong Liu, Wentao Li, Marianthi Chatziandreou, Tim Donselaar, Wenjuan Du, Ieva Drulyte, Berend-Jan Bosch, Joos

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern

ACE2 阻断抗体具有广泛的中和作用,可预防 Omicron 和其他令人担忧的 SARS-CoV-2 变体

Wenjuan Du, Daniel L Hurdiss, Dubravka Drabek, Anna Z Mykytyn, Franziska K Kaiser, Mariana González-Hernández, Diego Muñoz-Santos, Mart M Lamers, Rien van Haperen, Wentao Li, Ieva Drulyte, Chunyan Wang, Isabel Sola, Federico Armando, Georg Beythien, Malgorzata Ciurkiewicz, Wolfgang Baumgärtner, Kate

Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11

人源单克隆抗体 47D11 对 SARS-CoV 和 SARS-CoV-2 交叉中和作用的结构洞察

Juliette Fedry, Daniel L Hurdiss, Chunyan Wang, Wentao Li, Gonzalo Obal, Ieva Drulyte, Wenjuan Du, Stuart C Howes, Frank J M van Kuppeveld, Friedrich Förster, Berend-Jan Bosch

Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans

冠状病毒-HKU1血凝素酯酶的低温电子显微镜结构揭示了人体长期循环引起的结构变化

Daniel L Hurdiss, Ieva Drulyte #, Yifei Lang #, Tatiana M Shamorkina, Matti F Pronker, Frank J M van Kuppeveld, Joost Snijder, Raoul J de Groot

The Effect of Processing on Digestion of Legume Proteins

加工对豆类蛋白质消化的影响

Drulyte, Donata; Orlien, Vibeke