Immunoprofiling at an Institutional Scale Reveals That High Numbers of Intratumoral CD8(+) and PD-1(+) Cells Predict Superior Patient Survival Across Major Cancer Types Independent of Major Risk Factors
机构层面的免疫分析表明，肿瘤内CD8(+)和PD-1(+)细胞数量高可预测主要癌症类型患者的更高生存率，且与主要风险因素无关。
期刊:Jco Precision Oncology
影响因子:5.6
doi:10.1200/PO-25-00240
Alessi, Joao V; Lindsay, James R; Giobbie-Hurder, Anita; Sharma, Bijaya; Felt, Kristen; Kumari, Priti; Mazor, Tali; Cerami, Ethan; Lotter, William; Altreuter, Jennifer; Weirather, Jason; Dryg, Ian; Hoebel, Katharina; Manos, Michael; Adib, Elio; Curtis, Jennifer D; Ricciuti, Biagio; Di Federico, Alessandro; Ghandour, Fatme; Saad, Eddy; Wang, Xin-An; Pecci, Federica; Holovatska, Marta; Gandhi, Malini M; Hughes, Melissa E; O'Meara, Tess A; Chan, Sabrina J; Pfaff, Kathleen; Konstantinopoulos, Panagiotis A; Hodi, F Stephan; Shipp, Margaret A; Signoretti, Sabina; Choueiri, Toni; Wei, Xiao X; Santagata, Sandro; Hanna, Glenn J; Lin, Nancy U; Tolaney, Sara M; Liu, Joyce; Sorger, Peter K; Lindeman, Neal; Sholl, Lynette M; Nowak, Jonathan A; Barbie, David; Awad, Mark M; Johnson, Bruce E; Rodig, Scott J
肿瘤
T细胞
肿瘤免疫
CD8
细胞生物学
PD-1
免疫/内分泌
