日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The nucleobase guanine at the 3'-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity

寡核苷酸RGLS4326 3'末端的核碱基鸟嘌呤导致脱靶AMPA受体抑制和中枢神经系统毒性

Valencia, Tania; Yen, Laura Y; Berman, Cindy; Vincent, Thomas; Davis, Scott; Varrone, Francesca; Huang, Jianfeng; Mastroianni, Jessica; Carlson, Morgan; Owen, Tate; Kamel, Amin; Drygin, Denis; Kinberger, Garth A; Gangwar, Shanti Pal; Yelshanskaya, Maria V; Ridley, John; Kirby, Robert; Alvarez, Jesus; Lakhia, Ronak; Patel, Vishal; Sobolevsky, Alexander I; Lee, Edmund C

CX-5461 Preferentially Induces Top2α-Dependent DNA Breaks at Ribosomal DNA Loci

CX-5461 优先诱导核糖体 DNA 位点的 Top2α 依赖性 DNA 断裂

Donald P Cameron, Jirawas Sornkom, Sameerh Alsahafi, Denis Drygin, Gretchen Poortinga, Grant A McArthur, Nadine Hein, Ross Hannan, Konstantin I Panov

Targeting RNA Polymerase I Transcription Activity in Osteosarcoma: Pre-Clinical Molecular and Animal Treatment Studies

针对骨肉瘤中的 RNA 聚合酶 I 转录活性:临床前分子和动物治疗研究

Chang-Won Kang, Anneke C Blackburn, Amos Hong Pheng Loh, Kuick Chick Hong, Jian Yuan Goh, Nadine Hein, Denis Drygin, Chris R Parish, Ross D Hannan, Katherine M Hannan, Lucy A Coupland

Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth

癌细胞分泌的细胞外囊泡通过 miR-122 抑制胰岛素分泌,从而损害全身葡萄糖稳态并促进肿瘤生长

Minghui Cao, Roi Isaac, Wei Yan, Xianhui Ruan, Li Jiang, Yuhao Wan, Jessica Wang, Emily Wang, Christine Caron, Steven Neben, Denis Drygin, Donald P Pizzo, Xiwei Wu, Xuxiang Liu, Andrew R Chin, Miranda Y Fong, Ziting Gao, Kaizhu Guo, Oluwole Fadare, Richard B Schwab, Yuan Yuan, Susan E Yost, Joanne M

The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma

RNA 聚合酶 I 转录抑制剂 CX-5461 在子宫平滑肌肉瘤中的治疗潜力

Chang-Won Kang, Katherine M Hannan, Anneke C Blackburn, Amos H P Loh, Kuick Chik Hong, Goh Jian Yuan, Nadine Hein, Denis Drygin, Ross D Hannan, Lucy A Coupland

Bioinformatics Predicted Linear Epitopes of the Major Coat Protein of the Beet Yellows Virus for Detection of the Virus in the Cell Extract of the Infected Plant

利用生物信息学方法预测甜菜黄化病毒主要外壳蛋白的线性表位,用于检测受感染植物细胞提取物中的病毒。

Skurat, Eugene V; Butenko, Konstantin O; Drygin, Yuri F

Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease

细胞周期停滞期间的核糖体生物合成促进 EMT 的发生和发展

Varsha Prakash, Brittany B Carson, Jennifer M Feenstra, Randall A Dass, Petra Sekyrova, Ayuko Hoshino, Julian Petersen, Yuan Guo, Matthew M Parks, Chad M Kurylo, Jake E Batchelder, Kristian Haller, Ayako Hashimoto, Helene Rundqivst, John S Condeelis, C David Allis, Denis Drygin, M Angela Nieto, Mich

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

抑制 Pol I 转录可通过靶向白血病起始细胞群来治疗小鼠和人类 AML

Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer R Devlin, Amee J George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon J Harriso

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

CX-5461 抑制 RNA 聚合酶 I 转录起始可激活非典型 ATM/ATR 信号

Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George, Katherine M Hannan, Gretchen Poortinga, Karen E Sheppard, Kum Kum Khanna, Ricky W Johnstone, Denis Drygin, Grant A McArthur, Richard B Pearson, El

Integrated transcriptomic and proteomic analysis identifies protein kinase CK2 as a key signaling node in an inflammatory cytokine network in ovarian cancer cells.

整合转录组学和蛋白质组学分析发现,蛋白激酶 CK2 是卵巢癌细胞炎症细胞因子网络中的关键信号节点

Kulbe Hagen, Iorio Francesco, Chakravarty Probir, Milagre Carla S, Moore Robert, Thompson Richard G, Everitt Gemma, Canosa Monica, Montoya Alexander, Drygin Denis, Braicu Ioana, Sehouli Jalid, Saez-Rodriguez Julio, Cutillas Pedro R, Balkwill Frances R