A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification
首创抑制剂 MLN4924（pevonedistat）通过抑制 UBE2M 依赖的 Neddylation 修饰，诱导人类肾细胞癌细胞周期停滞、衰老和凋亡
期刊:Cancer Chemotherapy and Pharmacology
影响因子:2.7
doi:10.1007/s00280-018-3582-z
Bo Xu, Yuyou Deng, Ran Bi, Haoran Guo, Chang Shu, Neelam Kumari Shah, Junliang Chang, Guanchen Liu, Yujun Du, Wei Wei, Chunxi Wang
信号转导
肿瘤
肾癌
肿瘤细胞
Apoptosis
Senescence
Human
