日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combination of a therapeutic cancer vaccine targeting the endogenous retroviral envelope protein ERVMER34-1 with immune-oncology agents facilitates expansion of neoepitope-specific T cells and promotes tumor control

将靶向内源性逆转录病毒包膜蛋白ERVMER34-1的治疗性癌症疫苗与免疫肿瘤药物联合使用,可促进新表位特异性T细胞的扩增并增强肿瘤控制。

Maldonado, Maria Del Mar; Gracia-Hernandez, Maria; Le, Loc Huu; Iida, Masafumi; Gulley, James L; Donahue, Renee N; Palena, Claudia; Schlom, Jeffrey; Hamilton, Duane H

Combination Therapy Approaches to Enhance the Efficacy of ERV-Targeting Vaccines in Cancer

联合疗法增强ERV靶向疫苗在癌症治疗中的疗效

Gracia-Hernandez, Maria; Maldonado, Maria Del Mar; Schlom, Jeffrey; Hamilton, Duane H

Hypothesis: the generation of T cells directed against neoepitopes employing immune-mediating agents other than neoepitope vaccines

假设:利用除新表位疫苗以外的免疫介导剂,产生针对新表位的T细胞

Schlom, Jeffrey; Donahue, Renee N; Palena, Claudia; Gameiro, Sofia R; Hodge, James W; Hamilton, Duane H; Gulley, James L

An Interleukin-15 Superagonist Enables Antitumor Efficacy of Natural Killer Cells Against All Molecular Variants of SCLC

白细胞介素-15超激动剂可增强自然杀伤细胞对所有分子变异型小细胞肺癌的抗肿瘤疗效

Fousek, Kristen; Horn, Lucas A; Qin, Haiyan; Dahut, Madeline; Iida, Masafumi; Yacubovich, Dan; Hamilton, Duane H; Thomas, Anish; Schlom, Jeffrey; Palena, Claudia

Fulvestrant increases the susceptibility of enzalutamide-resistant prostate cancer cells to NK-mediated lysis

氟维司群可提高恩扎卢胺耐药的前列腺癌细胞对NK细胞介导的溶解作用的敏感性。

Dahut, Madeline; Fousek, Kristen; Horn, Lucas A; Angstadt, Shantel; Qin, Haiyan; Hamilton, Duane H; Schlom, Jeffrey; Palena, Claudia

Exploiting docetaxel-induced tumor cell necrosis with tumor targeted delivery of IL-12

利用多西他赛诱导的肿瘤细胞坏死和 IL-12 的肿瘤靶向递送

S Elizabeth Franks #, Ginette S Santiago-Sanchez #, Kellsye P Fabian, Kristen Solocinski, Paul L Chariou, Duane H Hamilton, Joshua T Kowalczyk, Michelle R Padget, Sofia R Gameiro, Jeffrey Schlom, James W Hodge

Blockade of tumor-derived colony-stimulating factor 1 (CSF1) promotes an immune-permissive tumor microenvironment

阻断肿瘤来源的集落刺激因子1(CSF1)可促进免疫容许的肿瘤微环境。

Maria Del Mar Maldonado,Jeffrey Schlom,Duane H Hamilton

Combination therapies utilizing neoepitope-targeted vaccines

利用新表位靶向疫苗的联合疗法

Lee, Karin L; Schlom, Jeffrey; Hamilton, Duane H

Simultaneous inhibition of CXCR1/2, TGF-β, and PD-L1 remodels the tumor and its microenvironment to drive antitumor immunity

同时抑制 CXCR1/2、TGF-β 和 PD-L1 可重塑肿瘤及其微环境,从而驱动抗肿瘤免疫

Lucas A Horn, Jeffrey Riskin, Heidi A Hempel, Kristen Fousek, Hanne Lind, Duane H Hamilton, Kristen K McCampbell, Dean Y Maeda, John A Zebala, Zhen Su, Jeffrey Schlom, Claudia Palena

Cooperative Immune-Mediated Mechanisms of the HDAC Inhibitor Entinostat, an IL15 Superagonist, and a Cancer Vaccine Effectively Synergize as a Novel Cancer Therapy

HDAC抑制剂恩替诺特、IL-15超激动剂和癌症疫苗的协同免疫介导机制可有效发挥协同作用,成为一种新型癌症疗法。

Hicks, Kristin C; Knudson, Karin M; Lee, Karin L; Hamilton, Duane H; Hodge, James W; Figg, William D; Ordentlich, Peter; Jones, Frank R; Rabizadeh, Shahrooz; Soon-Shiong, Patrick; Schlom, Jeffrey; Gameiro, Sofia R