A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy.
曲妥珠单抗下铰链区内的单个蛋白水解切割会降低免疫效应功能和体内疗效
期刊:Breast Cancer Research
影响因子:5.6
doi:10.1186/bcr3240
Fan Xuejun, Brezski Randall J, Fa Ming, Deng Hui, Oberholtzer Allison, Gonzalez Anneliese, Dubinsky William P, Strohl William R, Jordan Robert E, Zhang Ningyan, An Zhiqiang
