日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses.

截短的核衣壳蛋白的进化通过抑制抗病毒反应来增强 SARS-CoV-2 的适应性。

期刊:PLoS Biology
影响因子:7.2
doi:10.1371/journal.pbio.3003646
Mulloy Rory P, Evseev Danyel, Sharlin Noga, Bui-Marinos Maxwell P, Lacasse Émile, Dubuc Isabelle, Flamand Louis, Corcoran Jennifer A
SARS-CoV-2
发表日期：2026
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Deficiency in platelet 12-lipoxygenase exacerbates inflammation and disease severity during SARS-CoV-2 infection.

血小板 12-脂氧合酶缺乏会加剧 SARS-CoV-2 感染期间的炎症和疾病严重程度

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2420441122
Dos S P Andrade Ana Claudia, Lacasse Emile, Dubuc Isabelle, Gudimard Leslie, Gravel Annie, Puhm Florian, Campolina-Silva Gabriel, Queiroz-Junior Celso, Allaeys Isabelle, Prunier Julien, Azeggouar Wallen Oumaima, Dumais Élizabeth, Belleannée Clémence, Droit Arnaud, Flamand Nicolas, Boilard Éric, Flamand Louis
免疫/内分泌
新冠
炎症
发表日期：2025
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Delayed viral clearance and altered inflammatory responses affect severity of SARS-CoV-2 infection in aged mice

病毒清除延迟和炎症反应改变会影响老年小鼠SARS-CoV-2感染的严重程度。

期刊:Immunity & Ageing
影响因子:5.6
doi:10.1186/s12979-025-00503-1
Lacasse, Émile; Dubuc, Isabelle; Gudimard, Leslie; Andrade, Ana Claudia Dos S P; Gravel, Annie; Greffard, Karine; Chamberland, Alexandre; Oger, Camille; Galano, Jean-Marie; Durand, Thierry; Philipe, Éric; Blanchet, Marie-Renée; Bilodeau, Jean-François; Flamand, Louis
炎症/感染
炎症
SARS-CoV-2
微生物学
发表日期：2025
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A Benchmark of methods for SARS-CoV-2 whole genome sequencing and development of a more sensitive method

SARS-CoV-2全基因组测序方法基准测试及更灵敏方法的开发

期刊:Frontiers in Genetics
影响因子:2.8
doi:10.3389/fgene.2025.1516791
Bayega, Anthony; Reiling, Sarah J; Liu, Ju Ling; Dubuc, Isabelle; Gravel, Annie; Flamand, Louis; Ragoussis, Jiannis
SARS-CoV-2
发表日期：2025
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SARS-CoV-2 infection modifies the transcriptome of the megakaryocytes in the bone marrow

SARS-CoV-2感染会改变骨髓巨核细胞的转录组

期刊:Blood Advances
影响因子:7.1
doi:10.1182/bloodadvances.2023012367
Allaeys, Isabelle; Lemaire, Guillaume; Leclercq, Mickaël; Lacasse, Emile; Fleury, Maude; Dubuc, Isabelle; Gudimard, Leslie; Puhm, Florian; Tilburg, Julia; Stone, Andrew; Machlus, Kellie R; Droit, Arnaud; Flamand, Louis; Boilard, Eric
细胞生物学
炎症/感染
SARS-CoV-2
发表日期：2024
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SARS-CoV-2 rapidly evolves lineage-specific phenotypic differences when passaged repeatedly in immune-naïve mice

SARS-CoV-2 在免疫幼稚小鼠体内反复传代时，会迅速进化出谱系特异性的表型差异。

期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-024-05878-3
Willett, Julian Daniel Sunday; Gravel, Annie; Dubuc, Isabelle; Gudimard, Leslie; Dos Santos Pereira Andrade, Ana Claudia; Lacasse, Émile; Fortin, Paul; Liu, Ju-Ling; Cervantes, Jose Avila; Galvez, Jose Hector; Djambazian, Haig Hugo Vrej; Zwaig, Melissa; Roy, Anne-Marie; Lee, Sally; Chen, Shu-Huang; Ragoussis, Jiannis; Flamand, Louis
SARS-CoV-2
免疫/内分泌
发表日期：2024
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Pharmacological targeting of the hyper-inflammatory response to SARS-CoV-2-infected K18-hACE2 mice using a cluster of differentiation 36 receptor modulator

利用分化簇36受体调节剂对SARS-CoV-2感染的K18-hACE2小鼠的过度炎症反应进行药理学靶向治疗

期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2024.1303342
Gauvin, Jade; Huynh, David N; Dubuc, Isabelle; Lê, Catherine; Tugores, Rafaela; Flamand, Nicolas; Flamand, Louis; Lubell, William D; Ong, Huy; Marleau, Sylvie
SARS-CoV-2
炎症
炎症/感染
信号转导
ACE2
发表日期：2024
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Platelet activation by SARS-CoV-2 implicates the release of active tissue factor by infected cells

SARS-CoV-2 激活血小板涉及受感染细胞释放活性组织因子。

期刊:Blood Advances
影响因子:7.1
doi:10.1182/bloodadvances.2022007444
Puhm, Florian; Allaeys, Isabelle; Lacasse, Emile; Dubuc, Isabelle; Galipeau, Yannick; Zaid, Younes; Khalki, Loubna; Belleannée, Clemence; Durocher, Yves; Brisson, Alain R; Wolberg, Alisa S; Langlois, Marc-André; Flamand, Louis; Boilard, Eric
炎症/感染
细胞生物学
SARS-CoV-2
血小板
发表日期：2022
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A nanoparticle-based COVID-19 vaccine candidate elicits broad neutralizing antibodies and protects against SARS-CoV-2 infection

一种基于纳米颗粒的新冠病毒候选疫苗可诱导产生广谱中和抗体，并能预防SARS-CoV-2感染。

期刊:Nanomedicine-Nanotechnology Biology and Medicine
影响因子:4.6
doi:10.1016/j.nano.2022.102584
Olivera-Ugarte, Santa-Mariela; Bolduc, Marilène; Laliberté-Gagné, Marie-Ève; Blanchette, Léa-Jeanne; Garneau, Caroline; Fillion, Maude; Savard, Pierre; Dubuc, Isabelle; Flamand, Louis; Farnòs, Omar; Xu, Xingge; Kamen, Amine; Gilbert, Mégan; Rabezanahary, Henintsoa; Scarrone, Martina; Couture, Christian; Baz, Mariana; Leclerc, Denis
炎症/感染
新冠
SARS-CoV-2
微生物学
发表日期：2022
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Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19

趋化因子和类花生酸会加剧重症新冠肺炎患者肺部的过度炎症反应。

期刊:Journal of Allergy and Clinical Immunology
影响因子:11.2
doi:10.1016/j.jaci.2021.05.032
Zaid, Younes; Doré, Étienne; Dubuc, Isabelle; Archambault, Anne-Sophie; Flamand, Olivier; Laviolette, Michel; Flamand, Nicolas; Boilard, Éric; Flamand, Louis
肺炎
新冠
炎症
炎症/感染
微生物学
免疫/内分泌
发表日期：2021
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