日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting CDK12/13 Drives Mitotic Arrest to Overcome Resistance to KRASG12C Inhibitors

靶向 CDK12/13 可诱导有丝分裂停滞,从而克服对 KRASG12C 抑制剂的耐药性

Stern, Yaakov E; Ghosh, Pompom; Peroza, John; Solanki, Hitendra S; Imbody, Denis; Bridenstine, Liznair; Pandurangan, Thiyagamurthy; Frydman, Sylvia M; Nickens, Kathryn N; Walker-Mimms, Hannah L; Suvarna, Kruthi; Chaudhary, Neelkamal; Monastyrskyi, Andrii; Duckett, Derek; Haura, Eric B

GPCR systems coordinate cellular resilience against aging-associated stress

GPCR系统协调细胞抵抗衰老相关压力的能力

Boeringer, Tabitha; Pardo, Mia; Craig, Carter J; Gutierrez, Ainhoa Nieto; Duckett, Derek R; McDonald, Patricia; Maudsley, Stuart

Unravelling Convergent Signaling Mechanisms Underlying the Aging-Disease Nexus Using Computational Language Analysis.

利用计算语言分析揭示衰老与疾病之间联系的趋同信号机制

Junyent Marina, Noori Haki, De Schepper Robin, Frajdenberg Shanna, Elsaigh Razan Khalid Abdullah Hussen, McDonald Patricia H, Duckett Derek, Maudsley Stuart

CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity

CDK7 和 CDK9 抑制剂会干扰转录、翻译和干细胞特性,并诱导胶质母细胞瘤细胞毒性,且该作用与替莫唑胺敏感性无关。

Bhutada, Isha; Khambati, Fatema; Cheng, Shi-Yuan; Tiek, Deanna M; Duckett, Derek; Lawrence, Harshani; Vogelbaum, Michael A; Mo, Qianxing; Chellappan, Srikumar P; Padmanabhan, Jaya

An Epigenomic fingerprint of human cancers by landscape interrogation of super enhancers at the constituent level

通过对组成水平超级增强子进行景观分析,获得人类癌症的表观基因组指纹图谱

Liu, Xiang; Gillis, Nancy; Jiang, Chang; McCofie, Anthony; Shaw, Timothy I; Tan, Aik-Choon; Zhao, Bo; Wan, Lixin; Duckett, Derek R; Teng, Mingxiang

Structure-independent machine-learning predictions of the CDK12 interactome

CDK12相互作用组的与结构无关的机器学习预测

Karolak, Aleksandra; Urbaniak, Konstancja; Monastyrskyi, Andrii; Duckett, Derek R; Branciamore, Sergio; Stewart, Paul A

Summarizing internal dynamics boosts differential analysis and functional interpretation of super enhancers

总结内部动态有助于对超级增强子进行差异分析和功能解释。

Liu, Xiang; Zhao, Bo; Shaw, Timothy I; Fridley, Brooke L; Duckett, Derek R; Tan, Aik Choon; Teng, Mingxiang

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

利用小鼠 Ommaya 异种移植模型研究软脑膜疾病的直接靶向治疗

Law, Vincent; Baldwin, Margi; Ramamoorthi, Ganesan; Kodumudi, Krithika; Tran, Nam; Smalley, Inna; Duckett, Derek; Kalinski, Pawel; Czerniecki, Brian; Smalley, Keiran S M; Forsyth, Peter A

βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1

β-arrestin-1 通过作为 53BP1 的 E3 泛素连接酶接头来调节 DNA 修复。

Nieto, Ainhoa; Hara, Makoto R; Quereda, Victor; Grant, Wayne; Saunders, Vanessa; Xiao, Kunhong; McDonald, Patricia H; Duckett, Derek R

Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors

发现2-芳基喹唑啉衍生物作为一类新型ASK1抑制剂

Monastyrskyi, Andrii; Bayle, Simon; Quereda, Victor; Grant, Wayne; Cameron, Michael; Duckett, Derek; Roush, William