日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A phase I/II trial of WT1-specific TCR gene therapy for patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell transplantation: skewing towards NK-like phenotype impairs T cell function and persistence

一项针对接受异基因造血干细胞移植后仍处于活动期的急性髓系白血病患者的WT1特异性TCR基因治疗I/II期试验:NK样表型偏向会损害T细胞功能和持久性。

Mazziotta, Francesco; Martin, Lauren E; Egan, Daniel N; Bar, Merav; Kinsella, Sinéad; Paulson, Kelly G; Voillet, Valentin; Lahman, Miranda C; Hunter, Daniel; Schmitt, Thomas M; Duerkopp, Natalie; Yeung, Cecilia C S; Tang, Tzu-Hao; Gottardo, Raphael; Asano, Yuta; Wilcox, Elise C; Lee, Bo; Zhang, Tianzi; Lopedote, Paolo; Penter, Livius; Wu, Catherine J; Milano, Filippo; Greenberg, Philip D; Chapuis, Aude G

Acute Myeloid Leukemia Skews Therapeutic WT1-specific CD8 TCR-T Cells Towards an NK-like Phenotype that Compromises Function and Persistence

急性髓系白血病使治疗性WT1特异性CD8 TCR-T细胞向NK样表型转变,从而损害其功能和持久性。

Mazziotta, Francesco; Martin, Lauren E; Eagan, Daniel N; Bar, Merav; Kinsella, Sinéad; Paulson, Kelly G; Voillet, Valentin; Lahman, Miranda C; Hunter, Daniel; Schmitt, Thomas M; Duerkopp, Natalie; Yeung, Cecilia; Tang, Tzu-Hao; Gottardo, Raphael; Asano, Yuta; Wilcox, Elise C; Lee, Bo; Zhang, Tianzi; Lopedote, Paolo; Penter, Livius; Wu, Catherine J; Milano, Filippo; Greenberg, Philip D; Chapuis, Aude G

T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant

靶向WT1的T细胞受体基因疗法可预防移植后急性髓系白血病复发

Aude G Chapuis # ,Daniel N Egan # ,Merav Bar # ,Thomas M Schmitt ,Megan S McAfee ,Kelly G Paulson ,Valentin Voillet ,Raphael Gottardo ,Gunnar B Ragnarsson ,Marie Bleakley ,Cecilia C Yeung ,Petri Muhlhauser ,Hieu N Nguyen ,Lara A Kropp ,Luca Castelli ,Felecia Wagener ,Daniel Hunter ,Marcus Lindberg ,Kristen Cohen ,Aaron Seese ,M Juliana McElrath ,Natalie Duerkopp ,Ted A Gooley ,Philip D Greenberg

A Public Database of Memory and Naive B-Cell Receptor Sequences

记忆性和幼稚性B细胞受体序列公共数据库

DeWitt, William S; Lindau, Paul; Snyder, Thomas M; Sherwood, Anna M; Vignali, Marissa; Carlson, Christopher S; Greenberg, Philip D; Duerkopp, Natalie; Emerson, Ryan O; Robins, Harlan S

Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients

移植的WT1反应性CD8+ T细胞可以介导抗白血病活性,并在移植后患者体内持续存在。

Chapuis, Aude G; Ragnarsson, Gunnar B; Nguyen, Hieu N; Chaney, Colette N; Pufnock, Jeffrey S; Schmitt, Thomas M; Duerkopp, Natalie; Roberts, Ilana M; Pogosov, Galina L; Ho, William Y; Ochsenreither, Sebastian; Wölfl, Matthias; Bar, Merav; Radich, Jerald P; Yee, Cassian; Greenberg, Philip D