日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RIG-I agonists promote antigen-spreading and facilitate durable CAR-T responses in pancreatic ductal adenocarcinoma.

RIG-I 激动剂可促进抗原扩散,并促进胰腺导管腺癌中持久的 CAR-T 反应。

Senz Anne Marie, Cadilha Bruno L, Teppert Julia, Formisano Simone, Marx Charlotte, Lorenzini Theo, Boehmer Daniel F R, Hoerth Christine, Delahais Simon, Endres Stefan, Duewell Peter, Schnurr Max, Kobold Sebastian, Koenig Lars M

PIP4K attenuates PIP5K lipid kinase activity by disrupting membrane-mediated dimerization.

PIP4K 通过破坏膜介导的二聚化作用来减弱 PIP5K 脂质激酶活性。

Duewell Benjamin R, Chirumbolo Michael J, Fernandez-Ortiz Samantha M, Hammond Gerald R V, Hansen Scott D

Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

PI3Kβ受体酪氨酸激酶、GβGγ和Rho家族GTP酶协同激活的分子解析

Benjamin R Duewell # ,Naomi E Wilson # ,Gabriela M Bailey ,Sarah E Peabody ,Scott D Hansen

Molecular basis of product recognition during PIP5K-mediated production of PI(4,5)P2 with positive feedback

PIP5K介导的PI(4,5)P2生成过程中产物识别的分子基础及其正反馈机制

Benjamin R Duewell ,Katherine A Faris ,Scott D Hansen

IL18 Receptor Signaling Regulates Tumor-Reactive CD8+ T-cell Exhaustion via Activation of the IL2/STAT5/mTOR Pathway in a Pancreatic Cancer Model

IL18 受体信号通过激活胰腺癌模型中的 IL2/STAT5/mTOR 通路调节肿瘤反应性 CD8+ T 细胞耗竭

Veronika Lutz #, Veronique M Hellmund #, Felix S R Picard, Hartmann Raifer, Teresa Ruckenbrod, Matthias Klein, Tobias Bopp, Rajkumar Savai, Peter Duewell, Corinna U Keber, Andreas Weigert, Ho-Ryun Chung, Malte Buchholz, André Menke, Thomas M Gress, Magdalena Huber #, Christian Bauer #

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

Ras 和 GPCR 对 PI3Kγ 的 p101 和 p84 复合物进行差异激活的分子基础

Manoj K Rathinaswamy, Meredith L Jenkins, Benjamin R Duewell, Xuxiao Zhang, Noah J Harris, John T Evans, Jordan T B Stariha, Udit Dalwadi, Kaelin D Fleming, Harish Ranga-Prasad, Calvin K Yip, Roger L Williams, Scott D Hansen, John E Burke

Membrane-mediated dimerization potentiates PIP5K lipid kinase activity

膜介导的二聚化增强 PIP5K 脂质激酶活性

Scott D Hansen, Albert A Lee, Benjamin R Duewell, Jay T Groves

OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis

OAS1/RNase L 执行 RIG-I 配体依赖性肿瘤细胞凋亡

Daniel F R Boehmer, Simone Formisano, Carina C de Oliveira Mann, Stephan A Mueller, Michael Kluge, Philipp Metzger, Meino Rohlfs, Christine Hörth, Lorenz Kocheise, Stefan F Lichtenthaler, Karl-Peter Hopfner, Stefan Endres, Simon Rothenfusser, Caroline C Friedel, Peter Duewell, Max Schnurr, Lars M Ko

RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade

基于RIG-I的免疫疗法可提高临床前AML模型中的生存率,并使AML细胞对检查点阻断疗法更加敏感。

Ruzicka, Michael; Koenig, Lars M; Formisano, Simone; Boehmer, Daniel F R; Vick, Binje; Heuer, Eva-M; Meinl, Hanna; Kocheise, Lorenz; Zeitlhöfler, Marcus; Ahlfeld, Julia; Kobold, Sebastian; Endres, Stefan; Subklewe, Marion; Duewell, Peter; Schnurr, Max; Jeremias, Irmela; Lichtenegger, Felix S; Rothenfusser, Simon

Systemic but not MDSC-specific IRF4 deficiency promotes an immunosuppressed tumor microenvironment in a murine pancreatic cancer model

系统性而非 MDSC 特异性 IRF4 缺陷在小鼠胰腺癌模型中促进了免疫抑制的肿瘤微环境

Philipp Metzger, Sabrina V Kirchleitner, Daniel F R Boehmer, Christine Hörth, Angelika Eisele, Steffen Ormanns, Matthias Gunzer, Maciej Lech, Kirsten Lauber, Stefan Endres, Peter Duewell, Max Schnurr, Lars M König