日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting tau in Alzheimer's Disease: rationale, approach and challenges

靶向治疗阿尔茨海默病中的tau蛋白:理论基础、方法和挑战

Aslanyan, Aram; Foiani, Martha S; Giovannucci, Tatiana A; McDade, Eric; Duff, Karen E; Mummery, Catherine J; Schöll, Michael; Wildsmith, Kristin R; Paterson, Ross W

Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice

APOE4等位基因剂量对老年小鼠内嗅皮层脂质组学特征的影响

Miranda, André Miguel; Ashok, Archana; Chan, Robin Barry; Zhou, Bowen; Xu, Yimeng; McIntire, Laura Beth; Area-Gomez, Estela; Di Paolo, Gilbert; Duff, Karen E; Oliveira, Tiago Gil; Nuriel, Tal

In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease

阿尔茨海默病中tau蛋白种子积累的体内限速步骤

Meisl, Georg; Hidari, Eric; Allinson, Kieren; Rittman, Timothy; DeVos, Sarah L; Sanchez, Justin S; Xu, Catherine K; Duff, Karen E; Johnson, Keith A; Rowe, James B; Hyman, Bradley T; Knowles, Tuomas P J; Klenerman, David

Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus

化学遗传学方法减弱内嗅皮层神经元活动可减少海马体中的Aβ和tau蛋白病理。

Rodriguez, Gustavo A; Barrett, Geoffrey M; Duff, Karen E; Hussaini, S Abid

Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy

在进行性tau蛋白病的鼠模型中,与tau蛋白病理相关的萎缩先于明显的细胞死亡。

Fung, Christine W; Guo, Jia; Fu, Hongjun; Figueroa, Helen Y; Konofagou, Elisa E; Duff, Karen E

Unilateral Focused Ultrasound-Induced Blood-Brain Barrier Opening Reduces Phosphorylated Tau from The rTg4510 Mouse Model

单侧聚焦超声诱导血脑屏障开放可降低rTg4510小鼠模型中的磷酸化tau蛋白水平

Karakatsani, Maria Eleni; Kugelman, Tara; Ji, Robin; Murillo, Maria; Wang, Shutao; Niimi, Yusuke; Small, Scott A; Duff, Karen E; Konofagou, Elisa E

Targeting the 26S Proteasome To Protect Against Proteotoxic Diseases

靶向26S蛋白酶体以预防蛋白毒性疾病

Myeku, Natura; Duff, Karen E

Selective vulnerability in neurodegenerative diseases

神经退行性疾病中的选择性脆弱性

Fu, Hongjun; Hardy, John; Duff, Karen E

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology

APOE4 小鼠由于抑制性张力丧失而导致神经元过度活跃,但缺乏阿尔茨海默病样病理。

Nuriel, Tal; Angulo, Sergio L; Khan, Usman; Ashok, Archana; Chen, Qiuying; Figueroa, Helen Y; Emrani, Sheina; Liu, Li; Herman, Mathieu; Barrett, Geoffrey; Savage, Valerie; Buitrago, Luna; Cepeda-Prado, Efrain; Fung, Christine; Goldberg, Eliana; Gross, Steven S; Hussaini, S Abid; Moreno, Herman; Small, Scott A; Duff, Karen E

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.

Tau蛋白病理导致兴奋性神经元丢失、网格细胞功能障碍和空间记忆缺陷,类似于早期阿尔茨海默病

Fu Hongjun, Rodriguez Gustavo A, Herman Mathieu, Emrani Sheina, Nahmani Eden, Barrett Geoffrey, Figueroa Helen Y, Goldberg Eliana, Hussaini S Abid, Duff Karen E