日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans

在啮齿动物和人类惊恐障碍实验模型中对新型选择性食欲素-1受体拮抗剂JNJ-61393215进行转化评价

期刊:Translational Psychiatry
影响因子:6.2
doi:10.1038/s41398-020-00937-9
Salvadore, Giacomo; Bonaventure, Pascal; Shekhar, Anantha; Johnson, Philip L; Lord, Brian; Shireman, Brock T; Lebold, Terry P; Nepomuceno, Diane; Dugovic, Christine; Brooks, Sander; Zuiker, Rob; Bleys, Cathy; Tatikola, Kanaka; Remmerie, Bart; Jacobs, Gabriel E; Schruers, Koen; Moyer, John; Nash, Abigail; Van Nueten, Luc G M; Drevets, Wayne C
信号转导
发表日期：2020
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Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793

取代的氮杂双环[2.2.1]庚烷作为选择性食欲素-1拮抗剂：JNJ-54717793的发现

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.0c00085
Préville, Cathy; Bonaventure, Pascal; Koudriakova, Tatiana; Lord, Brian; Nepomuceno, Diane; Rizzolio, Michele; Mani, Neelakandha; Coe, Kevin J; Ndifor, Anthony; Dugovic, Christine; Dvorak, Curt A; Coate, Heather; Pippel, Daniel J; Fitzgerald, Anne; Allison, Brett; Lovenberg, Timothy W; Carruthers, Nicholas I; Shireman, Brock T
发表日期：2020
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SUN-482 Nitric Oxide Induces Spexin (Spx), Galanin Receptor 2 (GalR2), and Galanin Receptor 3 (GalR3) mRNA Independently of the cGMP/PKG Pathway and Enhances C/EBP-β Binding to the Spx 5’ Regulatory Region

SUN-482 一氧化氮可独立于 cGMP/PKG 通路诱导 Spexin (Spx)、Galanin 受体 2 (GalR2) 和 Galanin 受体 3 (GalR3) mRNA 的表达，并增强 C/EBP-β 与 Spx 5' 调控区的结合。

期刊:Frontiers in Neuroscience
影响因子:3.2
doi:10.3389/fnins.2014.00107
Aluisio, Leah; Fraser, Ian; Berdyyeva, Tamara; Tryputsen, Volha; Shireman, Brock T; Shoblock, James; Lovenberg, Timothy; Dugovic, Christine; Bonaventure, Pascal; Tran, Andy; Belsham, Denise
信号转导
EBP
发表日期：2019
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Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation

评估新型脑渗透性选择性食欲素 1 受体拮抗剂 JNJ-54717793 在两种惊恐发作诱发大鼠模型中的作用

期刊:Frontiers in Pharmacology
影响因子:4.4
doi:10.3389/fphar.2017.00357
Pascal Bonaventure, Christine Dugovic, Brock Shireman, Cathy Preville, Sujin Yun, Brian Lord, Diane Nepomuceno, Michelle Wennerholm, Timothy Lovenberg, Nicolas Carruthers, Stephanie D Fitz, Anantha Shekhar, Philip L Johnson
神经科学
Rat
信号转导
发表日期：2017
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Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice

选择性抑制食欲素-2受体可阻止小鼠应激诱导的ACTH释放

期刊:Frontiers in Behavioral Neuroscience
影响因子:2.9
doi:10.3389/fnbeh.2017.00083
Yun, Sujin; Wennerholm, Michelle; Shelton, Jonathan E; Bonaventure, Pascal; Letavic, Michael A; Shireman, Brock T; Lovenberg, Timothy W; Dugovic, Christine
ACTH
信号转导
发表日期：2017
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Direct Imaging of Hippocampal Epileptiform Calcium Motifs Following Kainic Acid Administration in Freely Behaving Mice

自由活动小鼠注射海人酸后海马癫痫样钙基序的直接成像

期刊:Frontiers in Neuroscience
影响因子:3.2
doi:10.3389/fnins.2016.00053
Tamara K Berdyyeva, E Paxon Frady, Jonathan J Nassi, Leah Aluisio, Yauheniya Cherkas, Stephani Otte, Ryan M Wyatt, Christine Dugovic, Kunal K Ghosh, Mark J Schnitzer, Timothy Lovenberg, Pascal Bonaventure
神经
癫痫
Hippo
发表日期：2016
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Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8

选择性 TARP-γ8 的 AMPA 受体调节剂的发现和表征

期刊:Journal of Pharmacology and Experimental Therapeutics
影响因子:3.1
doi:10.1124/jpet.115.231712
Michael P Maher, Nyantsz Wu, Suchitra Ravula, Michael K Ameriks, Brad M Savall, Changlu Liu, Brian Lord, Ryan M Wyatt, Jose A Matta, Christine Dugovic, Sujin Yun, Luc Ver Donck, Thomas Steckler, Alan D Wickenden, Nicholas I Carruthers, Timothy W Lovenberg
信号转导
发表日期：2016
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Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides

自组装成纳米粒子对于治疗性反义寡核苷酸的受体介导吸收至关重要

期刊:Nano Letters
影响因子:9.6
doi:10.1021/acs.nanolett.5b00490
Kariem Ezzat, Yoshitsugu Aoki, Taeyoung Koo, Graham McClorey, Leif Benner, Anna Coenen-Stass, Liz O'Donovan, Taavi Lehto, Antonio Garcia-Guerra, Joel Nordin, Amer F Saleh, Mark Behlke, John Morris, Aurelie Goyenvalle, Branislav Dugovic, Christian Leumann, Siamon Gordon, Michael J Gait, Samir El-Anda
信号转导
发表日期：2015
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A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects

选择性食欲素-1受体拮抗剂可减轻应激诱导的过度唤醒，且无催眠作用。

期刊:Journal of Pharmacology and Experimental Therapeutics
影响因子:3.8
doi:10.1124/jpet.114.220392
Bonaventure, Pascal; Yun, Sujin; Johnson, Philip L; Shekhar, Anantha; Fitz, Stephanie D; Shireman, Brock T; Lebold, Terry P; Nepomuceno, Diane; Lord, Brian; Wennerholm, Michelle; Shelton, Jonathan; Carruthers, Nicholas; Lovenberg, Timothy; Dugovic, Christine
信号转导
发表日期：2015
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Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism

在存在食欲素-2受体拮抗剂的情况下，食欲素-1受体阻断会扰乱快速眼动睡眠。

期刊:Frontiers in Neuroscience
影响因子:3.2
doi:10.3389/fnins.2014.00028
Dugovic, Christine; Shelton, Jonathan E; Yun, Sujin; Bonaventure, Pascal; Shireman, Brock T; Lovenberg, Timothy W
信号转导
发表日期：2014
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