日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments.

阿尔茨海默病蛋白病变 tau 种子在生化上是成熟成对螺旋丝的不完全形式

Kumar Mukesh, Quittot Noé, Dujardin Simon, Schlaffner Christoph N, Viode Arthur, Wiedmer Anne, Beerepoot Pieter, Chun Joshua E, Glynn Calina, Fernandes Analiese R, Donahue Cameron, Steen Judith A, Hyman Bradley T

Rate of tau propagation is a heritable disease trait in genetically diverse mouse strains.

tau 蛋白的传播速率是遗传多样性小鼠品系中的一种可遗传疾病特征

Welikovitch Lindsay A, Dujardin Simon, Dunn Amy R, Fernandes Analiese R, Khasnavis Anita, Chibnik Lori B, Kaczorowski Catherine C, Hyman Bradley T

Tau propagation is dependent on the genetic background of mouse strains

Tau蛋白的传播取决于小鼠品系的遗传背景。

Dujardin, Simon; Fernandes, Analiese; Bannon, Riley; Commins, Caitlin; De Los Santos, Mark; Kamath, Tarun V; Hayashi, Mansuo; Hyman, Bradley T

From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy

从朊病毒样传播假说到抗tau免疫疗法的治疗策略

Colin, Morvane; Dujardin, Simon; Schraen-Maschke, Susanna; Meno-Tetang, Guy; Duyckaerts, Charles; Courade, Jean-Philippe; Buée, Luc

Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds

接受蛋白病变tau种子的神经元中突触和代谢基因表达发生改变

Perez-Rando, Marta; Dujardin, Simon; Bennett, Rachel E; Commins, Caitlin; Nibhanupudy, Tara; Hyman, Bradley T

In vivo detection of tau fibrils and amyloid β aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy

利用发光共轭寡噻吩和多光子显微镜对tau蛋白原纤维和β淀粉样蛋白聚集体进行体内检测

Calvo-Rodriguez, Maria; Hou, Steven S; Snyder, Austin C; Dujardin, Simon; Shirani, Hamid; Nilsson, K Peter R; Bacskai, Brian J

Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo

在β-淀粉样蛋白存在的情况下,tau蛋白的减少可以预防体内tau蛋白病理和神经元死亡。

DeVos, Sarah L; Corjuc, Bianca T; Commins, Caitlin; Dujardin, Simon; Bannon, Riley N; Corjuc, Diana; Moore, Benjamin D; Bennett, Rachel E; Jorfi, Mehdi; Gonzales, Jose A; Dooley, Patrick M; Roe, Allyson D; Pitstick, Rose; Irimia, Daniel; Frosch, Matthew P; Carlson, George A; Hyman, Bradley T

What is the evidence that tau pathology spreads through prion-like propagation?

有什么证据表明tau蛋白病变是通过类似朊病毒的传播方式扩散的?

Mudher, Amrit; Colin, Morvane; Dujardin, Simon; Medina, Miguel; Dewachter, Ilse; Alavi Naini, Seyedeh Maryam; Mandelkow, Eva-Maria; Mandelkow, Eckhard; Buée, Luc; Goedert, Michel; Brion, Jean-Pierre

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies.

隧道纳米管(TNT)介导的病理性Tau蛋白聚集体的神经元间转移

Tardivel Meryem, Bégard Séverine, Bousset Luc, Dujardin Simon, Coens Audrey, Melki Ronald, Buée Luc, Colin Morvane