日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The SeqSplice multiplexed minigene splicing assay for characterization and quantitation of variant-induced BRCA1 and BRCA2 splice isoforms

用于表征和定量变异诱导的 BRCA1 和 BRCA2 剪接异构体的 SeqSplice 多重微基因剪接分析

Canson, Daffodil M; Parsons, Michael T; Moir-Meyer, Gemma; Dumenil, Troy; Montalban, Gemma; Lin, Erica; McVeigh, Terri P; Davidson, Aimee L; Bouckaert, Shaun M; Trau, Matt; Korbie, Darren; Spurdle, Amanda B

Fosl1 is a transcriptional effector of BRAF (V600E)-driven intestinal tumorigenesis

Fosl1是BRAF(V600E)驱动的肠道肿瘤发生的转录效应因子

Alam, Zakia; Nightingale, Rebecca; Lesmana, Analia; Liu, Cheng; Jenkins, Laura J; Richardson, Mark F; Croft, Lawrence; Luk, Ian Y; Reehorst, Camilla M; Chionh, Fiona; Vukelic, Natalia; Basheer, Faiza; Tulchinsky, Eugene; Badshah, Joshua; Dumenil, Troy; Bakiri, Latifa; Wagner, Erwin F; Tebbutt, Niall C; Whitehall, Vicki; Mariadason, John M; Dhillon, Amardeep S

Evolution of Zika virus in Rag1-deficient mice selects for unique envelope glycosylation motif mutants that show enhanced replication fitness.

在 Rag1 缺陷小鼠中,寨卡病毒的进化会筛选出具有独特包膜糖基化基序突变体,这些突变体表现出增强的复制适应性

Nakayama Eri, Tang Bing, Stewart Romal, Cox Abigail L, Yan Kexin, Bishop Cameron R, Dumenil Troy, Nguyen Wilson, Slonchak Andrii, Sng Julian, Khromykh Alexander A, Lutzky Viviana P, Rawle Daniel J, Suhrbier Andreas

Warmer ambient air temperatures reduce nasal turbinate and brain infection, but increase lung inflammation in the K18-hACE2 mouse model of COVID-19

在K18-hACE2 COVID-19小鼠模型中,较高的环境气温会减少鼻甲和脑部感染,但会加剧肺部炎症。

Dumenil, Troy; Le, Thuy T; Rawle, Daniel J; Yan, Kexin; Tang, Bing; Nguyen, Wilson; Bishop, Cameron; Suhrbier, Andreas

Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expression

COVID-19 小鼠模型重现的是炎症通路而非基因表达

Bishop, Cameron R; Dumenil, Troy; Rawle, Daniel J; Le, Thuy T; Yan, Kexin; Tang, Bing; Hartel, Gunter; Suhrbier, Andreas

APC Mutation Marks an Aggressive Subtype of BRAF Mutant Colorectal Cancers

APC基因突变是BRAF突变型结直肠癌的一种侵袭性亚型的标志

Fennell, Lochlan J; Kane, Alexandra; Liu, Cheng; McKeone, Diane; Fernando, Winnie; Su, Chang; Bond, Catherine; Jamieson, Saara; Dumenil, Troy; Patch, Ann-Marie; Kazakoff, Stephen H; Pearson, John V; Waddell, Nicola; Leggett, Barbara; Whitehall, Vicki L J

Contribution of mRNA Splicing to Mismatch Repair Gene Sequence Variant Interpretation

mRNA剪接对错配修复基因序列变异解读的贡献

Thompson, Bryony A; Walters, Rhiannon; Parsons, Michael T; Dumenil, Troy; Drost, Mark; Tiersma, Yvonne; Lindor, Noralane M; Tavtigian, Sean V; de Wind, Niels; Spurdle, Amanda B

Integrative Genome-Scale DNA Methylation Analysis of a Large and Unselected Cohort Reveals 5 Distinct Subtypes of Colorectal Adenocarcinomas

对一个大型未经筛选的队列进行整合基因组规模的DNA甲基化分析,揭示了5种不同的结直肠腺癌亚型

Fennell, Lochlan; Dumenil, Troy; Wockner, Leesa; Hartel, Gunter; Nones, Katia; Bond, Catherine; Borowsky, Jennifer; Liu, Cheng; McKeone, Diane; Bowdler, Lisa; Montgomery, Grant; Klein, Kerenaftali; Hoffmann, Isabell; Patch, Ann-Marie; Kazakoff, Stephen; Pearson, John; Waddell, Nicola; Wirapati, Pratyaksha; Lochhead, Paul; Imamura, Yu; Ogino, Shuji; Shao, Renfu; Tejpar, Sabine; Leggett, Barbara; Whitehall, Vicki

Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia

致癌性BRAF突变在人类锯齿状结直肠肿瘤的小鼠模型中诱导DNA甲基化改变

Bond, Catherine E; Liu, Cheng; Kawamata, Futoshi; McKeone, Diane M; Fernando, Winnie; Jamieson, Saara; Pearson, Sally-Ann; Kane, Alexandra; Woods, Susan L; Lannagan, Tamsin R M; Somashekar, Roshini; Lee, Young; Dumenil, Troy; Hartel, Gunter; Spring, Kevin J; Borowsky, Jennifer; Fennell, Lochlan; Bettington, Mark; Lee, Jason; Worthley, Daniel L; Leggett, Barbara A; Whitehall, Vicki L J

Copy number profiles of paired primary and metastatic colorectal cancers

配对的原发性和转移性结直肠癌的拷贝数谱

Kawamata, Futoshi; Patch, Ann-Marie; Nones, Katia; Bond, Catherine; McKeone, Diane; Pearson, Sally-Ann; Homma, Shigenori; Liu, Cheng; Fennell, Lochlan; Dumenil, Troy; Hartel, Gunter; Kobayasi, Nozomi; Yokoo, Hideki; Fukai, Moto; Nishihara, Hiroshi; Kamiyama, Toshiya; Burge, Matthew E; Karapetis, Christos S; Taketomi, Akinobu; Leggett, Barbara; Waddell, Nicola; Whitehall, Vicki