日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

KT-253, a Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy than MDM2 Small-Molecule Inhibitors.

KT-253 是一种新型 MDM2 降解剂和 p53 稳定剂,其效力和功效优于 MDM2 小分子抑制剂

Chutake Yogesh K, Mayo Michele F, Dumont Nancy, Filiatrault Jessica, Breitkopf Susanne B, Cho Patricia, Chen Dapeng, Dixit Vaishali S, Proctor William R, Kuhn Eric W, Bollinger Martinez Sarah, McDonald Alice A, Qi Jianfeng, Hu Kan-Nian, Karnik Rahul, Growney Joseph D, Sharma Kirti, Schalm Stefanie S, Gollerkeri Ashwin M, Mainolfi Nello, Williams Juliet A, Weiss Matthew M

Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform.

利用综合药物发现平台鉴定PPM1D小分子抑制剂

Shaw Subrata, Jiang Wei, Rush Jason, Dumont Nancy, Kim John, Singh Ritu, Skepner Adam, Khodier Carol, Raffier Cerise, Murphy Zachary, Yan Ni, Schluter Cameron, Yu Xiao, Szuchnicki Mateusz, Sathappa Murugappan, Kahn Josephine, Sperling Adam S, Wagner Florence, McKinney David C, Gould Alexandra E, Garvie Colin W, Miller Peter G

P464: PULSE DOSING OF POTENT AND SELECTIVE HETEROBIFUNCTIONAL MDM2 DEGRADER KT-253 DRIVES TUMOR REGRESSION AND DEMONSTRATES DIFFERENTIATED PHARMACOLOGY COMPARED TO P53/MDM2 SMALL MOLECULE INHIBITORS

P464:强效选择性异功能MDM2降解剂KT-253的脉冲给药可驱动肿瘤消退,并显示出与P53/MDM2小分子抑制剂不同的药理学特性

Liu, Xin-Yi; Yan, Yi-Zhi; Jiang, An-Jun; He, Wan-Ying; Fang, Ying-Yan; Li, Chao-Hui; Deng, Man-Fei; Tan, Si-Jie; Zeng, Peng; Schalm, Stefanie; Chutake, Yogesh; Breitkopf, Susanne; Mayo, Michele; Dumont, Nancy; Chen, Dapeng; Dixit, Vaishali; Karnik, Rahul; Mcdonald, Alice; Filiatrault, Jessica; Proctor, William; Qi, Frank; Hu, Kan-Nian; Weiss, Matt; Gollerkeri, Ashwin; Sharma, Kirti; D Growney, Joseph; Williams, Juliet

CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues

CD36抑制激活了高乳腺密度组织和肿瘤组织共有的多细胞基质程序。

DeFilippis, Rosa Anna; Chang, Hang; Dumont, Nancy; Rabban, Joseph T; Chen, Yunn-Yi; Fontenay, Gerald V; Berman, Hal K; Gauthier, Mona L; Zhao, Jianxin; Hu, Donglei; Marx, James J; Tjoe, Judy A; Ziv, Elad; Febbraio, Maria; Kerlikowske, Karla; Parvin, Bahram; Tlsty, Thea D

Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers

持续诱导上皮间质转化可激活基底样乳腺癌中沉默基因的DNA甲基化。

Dumont, Nancy; Wilson, Matthew B; Crawford, Yongping G; Reynolds, Paul A; Sigaroudinia, Mahvash; Tlsty, Thea D

Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases

阻断TGF-β可抑制乳腺肿瘤细胞的活力、迁移和转移

Muraoka, Rebecca S; Dumont, Nancy; Ritter, Christoph A; Dugger, Teresa C; Brantley, Dana M; Chen, Jin; Easterly, Evangeline; Roebuck, L Renee; Ryan, Sarah; Gotwals, Philip J; Koteliansky, Victor; Arteaga, Carlos L