日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Intracerebroventricular B7-H3-targeting CAR T cells for diffuse intrinsic pontine glioma: a phase 1 trial

脑室内注射靶向B7-H3的CAR-T细胞治疗弥漫性内生性桥脑胶质瘤:一项I期试验

Vitanza, Nicholas A; Ronsley, Rebecca; Choe, Michelle; Seidel, Kristy; Huang, Wenjun; Rawlings-Rhea, Stephanie D; Beam, Madison; Steinmetzer, Leonel; Wilson, Ashley L; Brown, Christopher; Beebe, Adam; Lindgren, Catherine; Gustafson, Joshua A; Wein, Amy; Holtzclaw, Susan; Hoeppner, Corrine; Goldstein, Hannah E; Browd, Samuel R; Hauptman, Jason S; Lee, Amy; Ojemann, Jeffrey G; Crotty, Erin E; Leary, Sarah E S; Perez, Francisco A; Wright, Jason N; Alonso, Marta M; Dun, Matthew D; Foster, Jessica B; Hurst, Diana; Kong, Ada; Thomsen, Alison; Orentas, Rimas J; Albert, Catherine M; Pinto, Navin; Annesley, Colleen; Gardner, Rebecca A; Ho, On; Pattabhi, Sowmya; Gust, Juliane; Wendler, Jason P; Park, Julie R; Jensen, Michael C

Correction: Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

更正:ONC201治疗H3K27M突变型弥漫性中线胶质瘤的临床疗效是由整合代谢和表观遗传通路紊乱驱动的

Venneti, Sriram; Kawakibi, Abed Rahman; Ji, Sunjong; Waszak, Sebastian M; Sweha, Stefan R; Mota, Mateus; Pun, Matthew; Deogharkar, Akash; Chung, Chan; Tarapore, Rohinton S; Ramage, Samuel; Chi, Andrew; Wen, Patrick Y; Arrillaga-Romany, Isabel; Batchelor, Tracy T; Butowski, Nicholas A; Sumrall, Ashley; Shonka, Nicole; Harrison, Rebecca A; de Groot, John; Mehta, Minesh; Hall, Matthew D; Daghistani, Doured; Cloughesy, Timothy F; Ellingson, Benjamin M; Beccaria, Kevin; Varlet, Pascale; Kim, Michelle M; Umemura, Yoshie; Garton, Hugh; Franson, Andrea; Schwartz, Jonathan; Jain, Rajan; Kachman, Maureen; Baum, Heidi; Burant, Charles F; Mottl, Sophie L; Cartaxo, Rodrigo T; John, Vishal; Messinger, Dana; Qin, Tingting; Peterson, Erik; Sajjakulnukit, Peter; Ravi, Karthik; Waugh, Alyssa; Walling, Dustin; Ding, Yujie; Xia, Ziyun; Schwendeman, Anna; Hawes, Debra; Yang, Fusheng; Judkins, Alexander R; Wahl, Daniel; Lyssiotis, Costas A; Nava, Daniel de la; Alonso, Marta M; Eze, Augustine; Spitzer, Jasper; Schmidt, Susanne V; Duchatel, Ryan J; Dun, Matthew D; Cain, Jason E; Jiang, Li; Stopka, Sylwia A; Baquer, Gerard; Regan, Michael S; Filbin, Mariella G; Agar, Nathalie Y R; Zhao, Lili; Kumar-Sinha, Chandan; Mody, Rajen; Chinnaiyan, Arul; Kurokawa, Ryo; Pratt, Drew; Yadav, Viveka N; Grill, Jacques; Kline, Cassie; Mueller, Sabine; Resnick, Adam; Nazarian, Javad; Allen, Joshua E; Odia, Yazmin; Gardner, Sharon L; Koschmann, Carl

Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for acute myeloid leukemia cell self-renewal

去甲基化药物诱导表观遗传和转录异质性,对急性髓系白血病细胞自我更新具有重要意义。

Bond, Danielle R; Burnard, Sean M; Uddipto, Kumar; Hunt, Kooper V; Harvey, Brooke M; Steffens Reinhardt, Luiza; Lawlor-O'Neill, Charley; Roper, Ellise A; Humphries, Sam; Murray, Heather C; Mannan, Abdul; Dun, Matthew D; de Bock, Charles E; Bowden, Nikola A; Enjeti, Anoop K; Verrills, Nicole M; Riveros, Carlos; Lê Cao, Kim-Anh; Lee, Heather J

Beyond base camp: PI3K/mTOR inhibition for the treatment of pediatric high-grade gliomas

超越大本营:PI3K/mTOR抑制剂治疗儿童高级别胶质瘤

Duchatel, Ryan J; Savary, Clara; Germon, Zacary P; Riley, Madisen; Ziegler, David S; Mueller, Sabine; Jackson, Evangeline R; Dun, Matthew D

DDDR-38. Leveraging the immunomodulatory effects of dordaviprone (ONC201) to induce long-term survival response in diffuse midline glioma patients and models

DDDR-38. 利用多达韦隆 (ONC201) 的免疫调节作用诱导弥漫性中线胶质瘤患者和模型获得长期生存反应

Bjerrum, Stephanie; Yang, Bada; Åhsberg, Johanna; Olbrich, Laura; Damkjær, Mathias Weis; Nathavitharana, Ruvandhi R; Broger, Tobias; Olaru, Ioana Diana; Sweetser, Brittney; Poore, Hayley; Razid, Alia; Kay, Alexander W; Denkinger, Claudia M; Schiller, Ian; Dendukuri, Nandini; Jaganath, Devan; Lundh, Andreas; Shah, Maunank; Savary, Clara; Persson, Mika L; Jackson, Evangeline R; Duchatel, Ryan J; Vo, Tuan; Findlay, Izac J; Douglas, Alicia M; Bramberger, Liesl; de la Nava, Daniel; Thomas, Bryce C; McEwen, Holly P; Beitaki, Tyrone S; de la Fuente, Laura Rodriguez; Colino-Sanguino, Yolanda; Mora, Fatima Valdes; Larsen, Martin R; Faridi, Pouya; Holst, Jeff; Mayall, Jemma; Kline, Cassie N; Franson, Andrea T; Venneti, Sriram; Hondermarck, Hubert; Horvat, Jay; Nixon, Brett; Cartaxo, Rodrigo; Nazarian, Javad; Hulleman, Esther; Mueller, Sabine; Vitanza, Nicholas A; Koschmann, Carl; Alonso, Marta M; Carvalheiro, Tiago Ferreira; van der Lugt, Jasper; Dun, Matthew D

ANGI-18. DISRUPTING INTEGRIN SIGNALING IMPAIRS MIGRATION, MYC-DRIVEN PURINE BIOSYNTHESIS, AND STEMNESS IN H3K27M DIFFUSE MIDLINE GLIOMAS

ANGI-18。干扰整合素信号传导会损害H3K27M弥漫性中线胶质瘤的迁移、MYC驱动的嘌呤生物合成和干性。

Angiolari, Federica; Coretti, Alessandro; Salanne, Mathieu; Bonella, Sara; Findlay, Izac; Staudt, Dilana; Duchatel, Ryan; Jackson, Evangeline; Persson, Mika; McEwen, Holly; Delevaux, Katherine; Smith, Nathan; Vitanza, Nicholas; Cain, Jason; Hansen, Mitchell; Alvaro, Frank; Jakobsen, Lene; Larsen, Martin; Savary, Clara; Waszak, Sebastian; Dun, Matthew; Ji, Sunjong; Doherty, Robert; Mota, Mateus; Natarajan, Siva Kumar; de la Nava, Daniel; Sajjakulnukit, Peter; Peterson, Erik R; Adam, Tiffany; Niculcea, Michael; Vo, Katie; Wink, Kelsey; Bavani, Subramaniam; Sridevi, Yadavilli; Nazarian, Javad; Phillips, Joanna J; Mueller, Sabine; Filbin, Mariella; Solomon, David A; Wahl, Daniel R; Lyssiotis, Costas; Qin, Tingting; Beck, Alexander; Viswanath, Pavithra; Nuechterlein, Nicholas; Waszak, Sebastian M; Venneti, Sriram; Koschmann, Carl; Schwark, Kallen; Miclea, Madeline; Patel, Tirth; Kong, Seongbae; Stanczak, Alina; Lau, Benison; Cartaxo, Rodrigo; Messinger, Dana; Doherty, Robert; Ji, Sunjong; Wadden, Jack; Clausen, Madison; Momen, Fareen; Adam, Tiffany; Wink, Kelsey; Hutchinson, Aria; Niculcea, Michael; Serhan, Habib; Merrill, Nathan; Edmonds, Amy; Mayr, Lisa; Neyazi, Sina; Muñoz, Denise; Nuechterlein, Nicholas; Fernandez, Ester Calvo; Califano, Andrea; Pavisic, Jovana; Garton, Hugh; Rao, Rama; Upadhyaya, Santhosh; Skrypek, Mary; Bendel, Anne; Lobbous, Mina; Klawinski, Darren; Merajver, Sofia; Koptyra, Mateusz; Resnick, Adam; Nazarian, Javad; Venneti, Sriram; Waszak, Sebastian; Chavez, Lukas; Beck, Alexander; Gojo, Johannes; Filbin, Mariella; Coppé, Jean-Philippe; Koschmann, Carl; Ahmad, Shiekh Tanveer; Li, Yiran; Garcia-Lopez, Jesus; Gudenas, Brian; Hadley, Jennifer; Paul, Leena; Wu, Stephanie; Refaat, Alaa; Kojic, Marija; Batts, Melissa; Soliman, Taha; Pitre, Aaron; Arnskötter, Frederik; Zindy, Frederique; Jones, Alun; Twarog, Nathaniel; Mayasundari, Anand; Bianski, Brandon; Tinkle, Christopher; Shirinifard, Abbas; Janke, Laura; Lu, Meifen; Lewis, Sara; Onar-Thomas, Arzu; Pfister, Stefan; Gajjar, Amar; Baker, Suzanne; Roussel, Martine; Rankovic, Zoran; Robinson, Giles; Orr, Brent; Wainwright, Brandon; Shelat, Anang; Waszak, Sebastian; Kutscher, Lena; Lin, Hong; Northcott, Paul; Doherty, Robert; Wink, Kelsey; Schwark, Kallen; Ji, Sunjong; Gera, Ananya; Messinger, Dana; de la Martin, Daniel Nava; Knowles, Truman; Subramaniam, Bavani; Millet, Yves; Waszak, Sebastian; Phillips, Joanna; Solomon, David; Nazarian, Javad; Mueller, Sabine; Beck, Alexander; Coppe, Jean-Phillipe; Koschmann, Carl; Cartaxo, Rodrigo T; de la Nava, Daniel; Nieblas-Bedolla, Edwin; Niculcea, Michael; Ji, Sunjong; Natarajan, Siva Kumar; Adam, Tiffany; Clausen, Madison; Miclea, Madeline; Siada, Ruby; Schwark, Kallen; Gera, Ananya; Doherty, Robert; Lyssiotis, Costas A; Favro, Noemi; Covato, Carmelo; Brunschwig, Lucas; Waszak, Sebastian M; Nuechterlein, Nicholas; Filbin, Mariella; Vo, Tuan; Dun, Matthew D; Venneti, Sriram; Hara, Toshiro; Koschmann, Carl

Exposure of mice to environmentally relevant per- and polyfluoroalkyl substances (PFAS) alters the sperm epigenome.

小鼠暴露于环境相关的全氟和多氟烷基物质(PFAS)会改变精子表观基因组。

Gillespie Leah, Martin Jacinta H, Anderson Amanda L, Bernstein Ilana R, Stanger Simone J, Trigg Natalie A, Schjenken John E, Gannon Anne-Louise, Parameswaran Shanu, Smyth Shannon P, Conine Colin C, Desai Reena, Handelsman David J, De Iuliis Geoffry N, Eamens Andrew L, Dun Matthew D, Turner Brett D, Roman Shaun D, Green Mark P, Nixon Brett

Beyond Base Camp: Promise and Pitfalls of PI3K/mTOR Inhibition in Pediatric High- Grade Gliomas

超越大本营:PI3K/mTOR抑制剂在儿童高级别胶质瘤治疗中的前景与陷阱

Duchatel, Ryan J; Savary, Clara; Germon, Zacary P; Riley, Madisen; Ziegler, David S; Mueller, Sabine; Jackson, Evangeline; Dun, Matthew D

Preclinical efficacy of combinatorial B7-H3 CAR T cells and ONC206 against diffuse intrinsic pontine glioma.

B7-H3 CAR T 细胞和 ONC206 联合治疗弥漫性内生性脑桥胶质瘤的临床前疗效。

Timpanaro Andrea, Song Edward Z, Toumi Ryma, Elena-Sanchez Leonel, Meechan Michael, Piccand Caroline, Nemec Kelsey, Kordowski Anja, Lau Davina, Johnson Scott, Winter Lily, Rajendran Ashmitha, Ronsley Rebecca, Oda Shannon K, Gustafson Joshua, Wendler Jason P, Koschmann Carl, Evans Myron, Pattwell Siobhan, Jensen Michael C, Foster Jessica B, Dun Matthew D, Biery Matthew C, Vitanza Nicholas A

PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma

PI3K/mTOR是弥漫性内生性脑桥胶质瘤中可作为治疗靶点的基因依赖性。

Duchatel, Ryan J; Jackson, Evangeline R; Parackal, Sarah G; Kiltschewskij, Dylan; Findlay, Izac J; Mannan, Abdul; Staudt, Dilana E; Thomas, Bryce C; Germon, Zacary P; Laternser, Sandra; Kearney, Padraic S; Jamaluddin, M Fairuz B; Douglas, Alicia M; Beitaki, Tyrone; McEwen, Holly P; Persson, Mika L; Hocke, Emily A; Jain, Vaibhav; Aksu, Michael; Manning, Elizabeth E; Murray, Heather C; Verrills, Nicole M; Sun, Claire Xin; Daniel, Paul; Vilain, Ricardo E; Skerrett-Byrne, David A; Nixon, Brett; Hua, Susan; de Bock, Charles E; Colino-Sanguino, Yolanda; Valdes-Mora, Fatima; Tsoli, Maria; Ziegler, David S; Cairns, Murray J; Raabe, Eric H; Vitanza, Nicholas A; Hulleman, Esther; Phoenix, Timothy N; Koschmann, Carl; Alvaro, Frank; Dayas, Christopher V; Tinkle, Christopher L; Wheeler, Helen; Whittle, James R; Eisenstat, David D; Firestein, Ron; Mueller, Sabine; Valvi, Santosh; Hansford, Jordan R; Ashley, David M; Gregory, Simon G; Kilburn, Lindsay B; Nazarian, Javad; Cain, Jason E; Dun, Matthew D