日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cas10 residues lining the target RNA binding channel regulate interference by distinguishing cognate target RNA from mismatched targets

Cas10残基排列在靶RNA结合通道上,通过区分同源靶RNA和错配靶RNA来调节干扰作用。

Khweis, Sarah A; Blackburn, Mason A; Perdigao, Calvin C; Pierce, Megan O; Lewis, Colby R; Dunkle, Jack A

Structural insights into target detection by the S. marcescens type III CRISPR complex and its deployment in SNP identification

沙雷氏菌III型CRISPR复合物靶标检测的结构解析及其在SNP鉴定中的应用

Perdigao, Calvin C; Ajisafe, Luqman O; Sunny, Anju T; Wu, Si; Dokland, Terje; Dunkle, Jack A

Two dynamic N-terminal regions are required for function in ribosomal RNA adenine dimethylase family members

核糖体RNA腺嘌呤二甲基酶家族成员的功能需要两个动态的N端区域。

McGaha, Danielle A; Collins, Alexandrea; Ajisafe, Luqman O; Perdigao, Calvin C; Bondrowski, Jordan L; Fetsch, Karen; Dunkle, Jack A

A Role for Two Conserved Arginine Residues in Protected Persulfide Transfer by SufE-Dependent SufS Cysteine Desulfurases

SufE依赖性SufS半胱氨酸脱硫酶在保护性过硫化物转移中发挥两个保守精氨酸残基的作用

Gogar, Rajleen K; Conte, Juliana V; Chhikara, Nidhi; Dunkle, Jack A; Frantom, Patrick A

The structure of the SufS-SufE complex reveals interactions driving protected persulfide transfer in iron-sulfur cluster biogenesis

SufS-SufE复合物的结构揭示了驱动铁硫簇生物合成过程中受保护的过硫化物转移的相互作用。

Gogar, Rajleen K; Chhikara, Nidhi; Vo, Minh; Gilbert, Nathaniel C; Dunkle, Jack A; Frantom, Patrick A

The structure of a Type III-A CRISPR-Cas effector complex reveals conserved and idiosyncratic contacts to target RNA and crRNA among Type III-A systems

III-A型CRISPR-Cas效应复合物的结构揭示了III-A型系统中与靶RNA和crRNA的保守和特异性接触。

Paraan, Mohammadreza; Nasef, Mohamed; Chou-Zheng, Lucy; Khweis, Sarah A; Schoeffler, Allyn J; Hatoum-Aslan, Asma; Stagg, Scott M; Dunkle, Jack A

Three critical regions of the erythromycin resistance methyltransferase, ErmE, are required for function supporting a model for the interaction of Erm family enzymes with substrate rRNA

红霉素耐药甲基转移酶 ErmE 的三个关键区域对其功能至关重要,这支持了 Erm 家族酶与底物 rRNA 相互作用的模型。

Sharkey, Rory E; Herbert, Johnny B; McGaha, Danielle A; Nguyen, Vy; Schoeffler, Allyn J; Dunkle, Jack A

The effect of crRNA-target mismatches on cOA-mediated interference by a type III-A CRISPR-Cas system

crRNA靶标错配对III-A型CRISPR-Cas系统介导的coOA干扰的影响

Nasef, Mohamed; Khweis, Sarah A; Dunkle, Jack A

Shared requirements for key residues in the antibiotic resistance enzymes ErmC and ErmE suggest a common mode of RNA recognition

抗生素耐药酶 ErmC 和 ErmE 对关键残基的共同需求表明它们可能具有共同的 RNA 识别模式。

Rowe, Sebastian J; Mecaskey, Ryan J; Nasef, Mohamed; Talton, Rachel C; Sharkey, Rory E; Halliday, Joshua C; Dunkle, Jack A

Structural evidence for a latch mechanism regulating access to the active site of SufS-family cysteine desulfurases

结构证据表明,存在一种闩锁机制调控SufS家族半胱氨酸脱硫酶活性位点的进入。

Dunkle, Jack A; Bruno, Michael R; Frantom, Patrick A