日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation

核磷蛋白支持WNT信号通路驱动的过度增殖和肿瘤起始

Kanellos, Georgios; Giacomelli, Chiara; Raven, Alexander; Vlahov, Nikola; Jin, Hu; Herviou, Pauline; Malla, Sudhir B; Nasreddin, Nadia; Centeno, Patricia P; Alexandrou, Constantinos; Gilroy, Kathryn; Baird, Rachel L; Pennel, Kathryn; Munro, June; Waldron, Joseph A; Hall, Holly; Officer-Jones, Leah; Bryson, Sheila; Strathdee, Douglas; Lilla, Sergio; Zanivan, Sara; Morrison, Vivienne; Nixon, Colin; Ridgway, Rachel A; Miller, Crispin; Knight, John R P; Campbell, Andrew D; Dunne, Philip D; Le Quesne, John; Edwards, Joanne; Park, Peter J; Bushell, Martin; Sansom, Owen J

Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer.

结直肠癌肿瘤微环境的治疗性调控和空间定量分析。

Mulholland-Illingworth Eoghan J, Moore Joshua W, Lin Muyang, Amirkhah Raheleh, Grzesiak Lucile, Ligeza Amelia, Bull Joshua A, Boen Joseph, Valbuena Gabriel N, Gillespie Michael A, Lannagan Tamsin R M, Gilroy Kathryn, Mills Megan L, Corry Shania M, Ridgway Rachel A, Belnoue-Davis Hayley L, Dunne Philip D, Sansom Owen J, Byrne Helen M, Leedham Simon J

Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis.

低覆盖率全基因组测序可以强有力地预测溃疡性结肠炎中低级别发育不良的进展为肿瘤的风险

Al Bakir Ibrahim, Curtius Kit, Cresswell George D, Grant Heather E, Nasreddin Nadia, Smith Kane, Nowinski Salpie, Guo Qingli, Belnoue-Davis Hayley L, Fisher Jennifer, Clarke Theo, Kimberley Christopher, Mossner Maximilian, Dunne Philip D, Loughrey Maurice B, Speight Ally, East James E, Wright Nicholas A, Rodriguez-Justo Manuel, Jansen Marnix, Moorghen Morgan, Baker Ann-Marie, Leedham Simon J, Hart Ailsa L, Graham Trevor A

Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis

基质细胞通过唾液酸/Siglec轴调节结直肠癌中的固有免疫细胞表型和功能。

O'Neill, Aoise; Zakaria, Norashikin; Bull, Courtney; Egan, Hannah; Corry, Shania M; Leonard, Niamh A; O'Meara, Clodagh; Howard, Linda; Walsh, Anastasija; Reidy, Eileen; Che, Jenny; Peng, Li; Cao, Lizhi; Egan, Laurence J; Ritter, Thomas; Sheehan, Margaret; Canney, Aoife; Culligan, Kevin; Hogan, Aisling M; Hynes, Sean O; Dunne, Philip D; O'Dwyer, Michael; Treacy, Oliver; Ryan, Aideen E

Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes.

恢复 NOX4 信号传导可逆转与实验性和临床糖尿病相关的内皮集落形成细胞血管生成功能障碍

O'Neill Karla M, Edgar Kevin S, Pun Shun Hay, Campbell David C, Toh Tinrui, Wong Xin N, Botezatu Bianca, Kandel Jyoti, McCoy Una, Nicell Jennifer, McClintock Catherine, McLoughlin Kiran J, Wu Yuxin, Madishetti Vinuthna Vani, Moez Arya, Alsaggaf Mohammed, Gill Eleanor K, Abudalo Rawan A, O'Neill Christina L, Pedrini Edoardo, Guduric-Fuchs Jasenka, Brunssen Coy, Morawietz Henning, Dunne Philip D, Watson Chris J, Medina Reinhold J, Grieve David J

Identification of a novel GREMLIN1 uptake pathway in epithelial cells that requires BMP binding.

鉴定出上皮细胞中一种新的 GREMLIN1 摄取途径,该途径需要 BMP 结合。

Gao Zhichun, Gao Yuhan, Dutton Louise R, Suner Melibea Berzosa, Todd Grace, Gipson Gregory R, Brown Connor, Kerr Emma M, Daly Carole, Plouffe Bianca, Dunne Philip D, Malinova Dessislava, Brazil Derek P

Smoking, alcohol, and colon cancer survival are modified by immune biomarkers: a population-representative study

吸烟、饮酒和结肠癌生存率受免疫生物标志物的影响:一项具有人群代表性的研究

Adali, Yasemin; Loughrey, Maurice B; Craig, Stephanie; Gray, Ronan T; James, Jacqueline A; Salto-Tellez, Manuel; Dunne, Philip D; Coleman, Helen G

Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer

作者更正:通路水平亚型分析识别出一种与结直肠癌不良临床结局相关的慢周期生物学表型

Malla, Sudhir B; Byrne, Ryan M; Lafarge, Maxime W; Corry, Shania M; Fisher, Natalie C; Tsantoulis, Petros K; Mills, Megan L; Ridgway, Rachel A; Lannagan, Tamsin R M; Najumudeen, Arafath K; Gilroy, Kathryn L; Amirkhah, Raheleh; Maguire, Sarah L; Mulholland, Eoghan J; Belnoue-Davis, Hayley L; Grassi, Elena; Viviani, Marco; Rogan, Emily; Redmond, Keara L; Sakhnevych, Svetlana; McCooey, Aoife J; Bull, Courtney; Hoey, Emily; Sinevici, Nicoleta; Hall, Holly; Ahmaderaghi, Baharak; Domingo, Enric; Blake, Andrew; Richman, Susan D; Isella, Claudio; Miller, Crispin; Bertotti, Andrea; Trusolino, Livio; Loughrey, Maurice B; Kerr, Emma M; Tejpar, Sabine; Maughan, Timothy S; Lawler, Mark; Campbell, Andrew D; Leedham, Simon J; Koelzer, Viktor H; Sansom, Owen J; Dunne, Philip D

Dual gene set enrichment analysis (dualGSEA); an R function that enables more robust biological discovery and pre-clinical model alignment from transcriptomics data

双基因集富集分析 (dualGSEA);一个 R 函数,可从转录组学数据中实现更稳健的生物学发现和临床前模型比对。

Bull, Courtney; Byrne, Ryan M; Fisher, Natalie C; Corry, Shania M; Amirkhah, Raheleh; Edwards, Jessica; Hillson, Lily V S; Lawler, Mark; Ryan, Aideen E; Lamrock, Felicity; Dunne, Philip D; Malla, Sudhir B

Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures

根据治疗方案和转录特征对直肠癌新辅助放疗进行分层

Mahmood, Umair; Blake, Andrew; Rathee, Sanjay; Samuel, Leslie; Murray, Graeme; Sebag-Montefiore, David; Gollins, Simon; West, Nicholas P; Begum, Rubina; Bach, Simon P; Richman, Susan D; Quirke, Phil; Redmond, Keara L; Salto-Tellez, Manuel; Koelzer, Viktor H; Leedham, Simon J; Tomlinson, Ian; Dunne, Philip D; Buffa, Francesca M; Maughan, Tim S; Domingo, Enric