Durai Sundar相关文献与解析，生知库 | 链接生命科学的每一步

Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells

预计醉茄酮和醉茄素-A 会与跨膜蛋白酶丝氨酸 2 (TMPRSS2) 相互作用，并阻止 SARS-CoV-2 进入细胞

期刊:Journal of Biomolecular Structure & Dynamics

doi:10.1080/07391102.2020.1775704

Vipul Kumar, Jaspreet Kaur Dhanjal, Priyanshu Bhargava, Ashish Kaul, Jia Wang, Huayue Zhang, Sunil C Kaul, Renu Wadhwa, Durai Sundar

COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays

醉茄内酯对 COVID19 的抑制作用涉及靶向宿主细胞表面受体 ACE2：从计算和生化分析中获得的见解

期刊:Journal of Biomolecular Structure & Dynamics

影响因子:2.7

doi:10.1080/07391102.2021.1902858

Rajkumar Singh Kalra, Vipul Kumar, Jaspreet Kaur Dhanjal, Sukant Garg, Xiaoshuai Li, Sunil C Kaul, Durai Sundar, Renu Wadhwa

Comparative computational and experimental analyses of some natural small molecules to restore transcriptional activation function of p53 in cancer cells harbouring wild type and p53Ser46 mutant

一些天然小分子对恢复野生型和 p53Ser46 突变型癌细胞中 p53 转录激活功能的比较计算和实验分析

期刊:Current Research in Structural Biology

影响因子:2.7

doi:10.1016/j.crstbi.2022.09.002

Seyad Shefrin, Anissa Nofita Sari, Vipul Kumar, Huayue Zhang, Hazna Noor Meidinna, Sunil C Kaul, Renu Wadhwa, Durai Sundar

A Low Dose Combination of Withaferin A and Caffeic Acid Phenethyl Ester Possesses Anti-Metastatic Potential In Vitro: Molecular Targets and Mechanisms

低剂量醉茄素 A 和咖啡酸苯乙酯的组合具有体外抗转移潜力：分子靶点和机制

期刊:Cancers

影响因子:

doi:10.3390/cancers14030787

Anissa Nofita Sari, Jaspreet Kaur Dhanjal, Ahmed Elwakeel, Vipul Kumar, Hazna Noor Meidinna, Huayue Zhang, Yoshiyuki Ishida, Keiji Terao, Durai Sundar, Sunil C Kaul, Renu Wadhwa

信号转导

发表日期：2022

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Molecular mechanism of anti-SARS-CoV2 activity of Ashwagandha-derived withanolides

南非醉茄衍生的醉茄内酯抗 SARS-CoV2 活性的分子机制

期刊:International Journal of Biological Macromolecules

影响因子:7.7

doi:10.1016/j.ijbiomac.2021.06.015

Jaspreet Kaur Dhanjal, Vipul Kumar, Sukant Garg, Chandru Subramani, Shubhra Agarwal, Jia Wang, Huayue Zhang, Ashish Kaul, Rajkumar Singh Kalra, Sunil C Kaul, Sudhanshu Vrati, Durai Sundar, Renu Wadhwa

Molecular dynamics simulations and experimental studies reveal differential permeability of withaferin-A and withanone across the model cell membrane

分子动力学模拟和实验研究揭示了醉茄素-A和醉茄酮在模型细胞膜上的渗透性差异

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-021-81729-z

Renu Wadhwa #, Neetu Singh Yadav #, Shashank P Katiyar, Tomoko Yaguchi, Chohee Lee, Hyomin Ahn, Chae-Ok Yun, Sunil C Kaul, Durai Sundar

Computational and in vitro experimental analyses of the anti-COVID-19 potential of Mortaparib and MortaparibPlus

Mortaparib 和 MortaparibPlus 抗 COVID-19 潜力的计算和体外实验分析

期刊:Bioscience Reports

影响因子:3.8

doi:10.1042/BSR20212156

Vipul Kumar, Anissa Nofita Sari, Hazna Noor Meidinna, Jaspreet Kaur Dhanjal, Chandru Subramani, Brohmomoy Basu, Sunil C Kaul, Sudhanshu Vrati, Durai Sundar, Renu Wadhwa

Mutant p53L194F Harboring Luminal-A Breast Cancer Cells Are Refractory to Apoptosis and Cell Cycle Arrest in Response to MortaparibPlus, a Multimodal Small Molecule Inhibitor

携带 Luminal-A 乳腺癌细胞的突变型 p53L194F 对多模式小分子抑制剂 MortaparibPlus 的凋亡和细胞周期停滞具有耐受性

期刊:Cancers

影响因子:

doi:10.3390/cancers13123043

Ahmed Elwakeel, Anissa Nofita Sari, Jaspreet Kaur Dhanjal, Hazna Noor Meidinna, Durai Sundar, Sunil C Kaul, Renu Wadhwa

Identification and Characterization of MortaparibPlus-A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms

MortaparibPlus 的鉴定和表征 - 一种靶向 Mortalin-p53 相互作用并通过野生型 p53 依赖性和非依赖性机制抑制癌细胞增殖的新型三唑衍生物

期刊:Cancers

影响因子:

doi:10.3390/cancers13040835

Anissa Nofita Sari, Ahmed Elwakeel, Jaspreet Kaur Dhanjal, Vipul Kumar, Durai Sundar, Sunil C Kaul, Renu Wadhwa

Identification of a new member of Mortaparib class of inhibitors that target mortalin and PARP1

鉴定出 Mortaparib 类抑制剂中的一种新成员，该抑制剂靶向 Mortalin 和 PARP1

Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells

预计醉茄酮和醉茄素-A 会与跨膜蛋白酶丝氨酸 2 (TMPRSS2) 相互作用，并阻止 SARS-CoV-2 进入细胞

COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays

醉茄内酯对 COVID19 的抑制作用涉及靶向宿主细胞表面受体 ACE2：从计算和生化分析中获得的见解

Comparative computational and experimental analyses of some natural small molecules to restore transcriptional activation function of p53 in cancer cells harbouring wild type and p53Ser46 mutant

一些天然小分子对恢复野生型和 p53Ser46 突变型癌细胞中 p53 转录激活功能的比较计算和实验分析

A Low Dose Combination of Withaferin A and Caffeic Acid Phenethyl Ester Possesses Anti-Metastatic Potential In Vitro: Molecular Targets and Mechanisms

低剂量醉茄素 A 和咖啡酸苯乙酯的组合具有体外抗转移潜力：分子靶点和机制

Molecular mechanism of anti-SARS-CoV2 activity of Ashwagandha-derived withanolides

南非醉茄衍生的醉茄内酯抗 SARS-CoV2 活性的分子机制

Molecular dynamics simulations and experimental studies reveal differential permeability of withaferin-A and withanone across the model cell membrane

分子动力学模拟和实验研究揭示了醉茄素-A和醉茄酮在模型细胞膜上的渗透性差异

Computational and in vitro experimental analyses of the anti-COVID-19 potential of Mortaparib and MortaparibPlus

Mortaparib 和 MortaparibPlus 抗 COVID-19 潜力的计算和体外实验分析

Mutant p53L194F Harboring Luminal-A Breast Cancer Cells Are Refractory to Apoptosis and Cell Cycle Arrest in Response to MortaparibPlus, a Multimodal Small Molecule Inhibitor

携带 Luminal-A 乳腺癌细胞的突变型 p53L194F 对多模式小分子抑制剂 MortaparibPlus 的凋亡和细胞周期停滞具有耐受性

Identification and Characterization of MortaparibPlus-A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms

MortaparibPlus 的鉴定和表征 - 一种靶向 Mortalin-p53 相互作用并通过野生型 p53 依赖性和非依赖性机制抑制癌细胞增殖的新型三唑衍生物