日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A Bacteroides fragilis protease activates host PAR(2) to induce intestinal pain and inflammation.

脆弱拟杆菌蛋白酶激活宿主PAR(2)，诱发肠道疼痛和炎症。

期刊:Cell Host & Microbe
影响因子:18.7
doi:10.1016/j.chom.2025.09.010
Lakemeyer Markus, Latorre Rocco, Blazkova Kristyna, Wood Hannah M, Jensen Dane D, Shakil Nayab, Thomas Scott C, Saxena Deepak, Mulpuri Yatendra, Poolman David, Duran Paz, Keller Laura J, Reed David E, Schmidt Brian L, Jiménez-Vargas Néstor N, Xu Fangxi, Lomax Alan E, Bunnett Nigel W, Bogyo Matthew
炎症/感染
炎症
发表日期：2025
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Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia

靶向内体中蛋白酶激活受体2的纳米药物可提供持续镇痛作用

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2412687122
Teng, Shavonne L; Latorre, Rocco; Bhansali, Divya; Lewis, Parker K; Pollard, Rachel E; Peach, Chloe J; Sokrat, Badr; Thanigai Arasu, Gokul Sriman; Chiu, Tracy; Duran, Paz; Jimenez-Vargas, Nestor N; Mocherniak, Abby; Bogyo, Matthew; Gaspari, Michael M; Vanner, Stephen J; Pinkerton, Nathalie M; W Leong, Kam; Schmidt, Brian L; Jensen, Dane D; Bunnett, Nigel W
信号转导
发表日期：2025
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Small molecule targeting Na V 1.7 via inhibition of CRMP2-Ubc9 interaction reduces pain-related outcomes in a rodent osteoarthritic model.

通过抑制 CRMP2-Ubc9 相互作用靶向 Na V 1.7 的小分子可减轻啮齿动物骨关节炎模型中的疼痛相关结果

期刊:Pain
影响因子:5.5
doi:10.1097/j.pain.0000000000003357
Hestehave Sara, Allen Heather N, Gomez Kimberly, Duran Paz, Calderon-Rivera Aida, Loya-López Santiago, Rodríguez-Palma Erick J, Khanna Rajesh
炎症/感染
关节炎
炎症
发表日期：2025
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The Leucine-Rich Repeat Kinase 2 Variant LRRK2(G2019S) Up-Regulates L-Type (CaV1.3) Calcium Channel via the Ca(V)β(3) Subunit: Possible Role in the Pathogenesis of Parkinson's Disease

富含亮氨酸重复激酶2变体LRRK2(G2019S)通过Ca(V)β(3)亚基上调L型(CaV1.3)钙通道：可能在帕金森病的发病机制中发挥作用

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms26073229
Sandoval, Alejandro; Corzo-López, Alejandra; Duran, Paz; Tovar-Soto, Diana; Vargas-Caballero, Bryan; Galicia-Saldaña, Valeria; González-Ramírez, Ricardo; Felix, Ricardo
LRRK2
信号转导
帕金森
神经科学
发表日期：2025
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Endosomal MrGPRX1 signaling sensitizes TRPV1 to enhance itch

内体MrGPRX1信号传导使TRPV1敏感化，从而增强瘙痒感。

期刊:
影响因子:
doi:10.1101/2025.11.12.688053
Duran, Paz; Retamal, Jeffri S; de Amorim Ferreira, Marcella; Trevett, Kai; Jensen, Dane D
信号转导
TRPV1
发表日期：2025
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C-H Functionalization-Enabled 11-Step Semisynthesis of (-)-Veragranine A and Characterization of Synthetic Analogs in Osteoarthritis-related Pain Treatment

CH 官能化实现的 11 步半合成 (-)-维拉格拉宁 A 及其合成类似物在骨关节炎相关疼痛治疗中的表征

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.4c04025
Ma, Donghui; Duran, Paz; Al-Ahmad, Reem; Hestehave, Sara; Joa, Margarita; Alsbiei, Omar; Rodríguez-Palma, Erick J; Li, Yanrong; Wang, Shilin; Khanna, Rajesh; Dai, Mingji
关节炎
发表日期：2024
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C2230, a preferential use- and state-dependent CaV2.2 channel blocker, mitigates pain behaviors across multiple pain models.

C2230 是一种优先使用和状态依赖的 CaV2.2 通道阻滞剂，可减轻多种疼痛模型中的疼痛行为

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI177429
Tang Cheng, Gomez Kimberly, Chen Yan, Allen Heather N, Hestehave Sara, Rodríguez-Palma Erick J, Loya-Lopez Santiago, Calderon-Rivera Aida, Duran Paz, Nelson Tyler S, Kanumuri Siva Rama Raju, Shah Bijal, Panigrahi Nihar R, Perez-Miller Samantha, Schackmuth Morgan K, Ruparel Shivani, Patwardhan Amol, Price Theodore J, Arora Paramjit S, Sharma Ravindra K, Sharma Abhisheak, Yu Jie, Korczeniewska Olga A, Khanna Rajesh
其它
发表日期：2024
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Uncoupling the CRMP2-Ca(V)2.2 Interaction Reduces Pain-Like Behavior in a Preclinical Joint-Pain Model.

解耦 CRMP2-Ca(V)2.2 相互作用可减少临床前关节疼痛模型中的疼痛样行为

期刊:Journal of Pain
影响因子:4
doi:10.1016/j.jpain.2024.104664
Allen Heather N, Hestehave Sara, Duran Paz, Nelson Tyler S, Khanna Rajesh
其它
发表日期：2024
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Regulating neuronal excitability: The role of S-palmitoylation in Na(V)1.7 activity and voltage sensitivity

调节神经元兴奋性：S-棕榈酰化在Na(V)1.7活性和电压敏感性中的作用

期刊:PNAS Nexus
影响因子:3.8
doi:10.1093/pnasnexus/pgae222
Tang, Cheng; Duran, Paz; Calderon-Rivera, Aida; Loya-Lopez, Santiago; Gomez, Kimberly; Perez-Miller, Samantha; Khanna, Rajesh
神经科学
发表日期：2024
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A peptidomimetic modulator of the Ca(V)2.2 N-type calcium channel for chronic pain

一种用于治疗慢性疼痛的 Ca(V)2.2 N 型钙通道的肽模拟调节剂

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2305215120
Gomez, Kimberly; Santiago, Ulises; Nelson, Tyler S; Allen, Heather N; Calderon-Rivera, Aida; Hestehave, Sara; Rodríguez Palma, Erick J; Zhou, Yuan; Duran, Paz; Loya-Lopez, Santiago; Zhu, Elaine; Kumar, Upasana; Shields, Rory; Koseli, Eda; McKiver, Bryan; Giuvelis, Denise; Zuo, Wanhong; Inyang, Kufreobong E; Dorame, Angie; Chefdeville, Aude; Ran, Dongzhi; Perez-Miller, Samantha; Lu, Yi; Liu, Xia; Handoko; Arora, Paramjit S; Patek, Marcel; Moutal, Aubin; Khanna, May; Hu, Huijuan; Laumet, Geoffroy; King, Tamara; Wang, Jing; Damaj, M Imad; Korczeniewska, Olga A; Camacho, Carlos J; Khanna, Rajesh
发表日期：2023
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