日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors

通过改造共信号受体来生成脱靶交叉反应性降低的T细胞

Cabezas-Caballero, Jose; Huhn, Anna; Kutuzov, Mikhail A; Andre, Violaine; Shomuradova, Alina; Peeters, Bas W A; Gillespie, Geraldine M; van der Merwe, P Anton; Dushek, Omer

Mixed-mobility supported lipid bilayers uncover the role of immobilized ICAM1 on T cell activation and immune synapse organization

混合迁移率支持的脂质双层揭示了固定化ICAM1在T细胞活化和免疫突触组织中的作用

Leithner, Alexander; Kvalvaag, Audun; Mitra, Tanmay; Valvo, Salvatore; Dada, Hannah; Compeer, Ewoud; Barton, Michael I; Eguiguren, Sofia Bustamante; Jenkins, Edward; Lagerholm, Christoffer; Dushek, Omer; Dustin, Michael L

Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens.

小鼠 T 细胞受体 OT-I 对外来抗原和自身抗原的区分能力不完美。

Huhn Anna, Kutuzov Mikhail A, Maclean Keir, Uhl Lion F K, Mahale Jagdish M, Gérard Audrey, van der Merwe P Anton, Dushek Omer

NanoBondy Reaction through NeissLock Anhydride Allows Covalent Immune Cell Decoration

通过奈斯洛克酸酐进行的纳米键合反应可实现免疫细胞的共价修饰

Vankayala, Lasya R; Adoni, Kish R; Lim, Sheryl Y T; Dam, Tommy; Dushek, Omer; Thalassinos, Konstantinos; Howarth, Mark R

Platforms for studying cell-cell recognition by immune cells

用于研究免疫细胞细胞间识别的平台

Kramer, Jordan; van der Merwe, P Anton; Dushek, Omer

G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics

基于G6b-B抗体的顺式作用血小板受体抑制剂(CAPRIs)作为一类新型抗血栓治疗药物

Mazharian, Alexandra; Bertin, Ophélie; Sarkar, Amrita; Augros, Johanna; Bornert, Alicia; Loubière, Cécile; Jönsson, Friederike; Warwicker, Juli; Abbott, W Mark; Dushek, Omer; Vayne, Caroline; Rauova, Lubica; Fütterer, Klaus; Rollin, Jérôme; Poncz, Mortimer; Senis, Yotis A

T cell microvilli simulations show operation near packing limit and impact on antigen recognition

T细胞微绒毛模拟显示,其在接近堆积极限时发挥作用,并影响抗原识别。

Morgan, Jonathan; Pettmann, Johannes; Dushek, Omer; Lindsay, Alan E

Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation

四级结构松弛引起的T细胞抗原受体信号传导的变构激活

Lanz, Anna-Lisa; Masi, Giulia; Porciello, Nicla; Cohnen, André; Cipria, Deborah; Prakaash, Dheeraj; Bálint, Štefan; Raggiaschi, Roberto; Galgano, Donatella; Cole, David K; Lepore, Marco; Dushek, Omer; Dustin, Michael L; Sansom, Mark S P; Kalli, Antreas C; Acuto, Oreste

Intrinsic Disorder in the T Cell Receptor Creates Cooperativity and Controls ZAP70 Binding

T细胞受体的内在无序性产生协同作用并控制ZAP70结合

Clemens, Lara; Dushek, Omer; Allard, Jun

A cell topography-based mechanism for ligand discrimination by the T cell receptor

T细胞受体基于细胞拓扑结构的配体识别机制

Fernandes, Ricardo A; Ganzinger, Kristina A; Tzou, Justin C; Jönsson, Peter; Lee, Steven F; Palayret, Matthieu; Santos, Ana Mafalda; Carr, Alexander R; Ponjavic, Aleks; Chang, Veronica T; Macleod, Charlotte; Lagerholm, B Christoffer; Lindsay, Alan E; Dushek, Omer; Tilevik, Andreas; Davis, Simon J; Klenerman, David