日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness

为应对大流行而鉴定高效广谱冠状病毒主蛋白酶抑制剂

David T Barkan ,Keira Garland ,Lei Zhang ,Richard T Eastman ,Matthew Hesse ,Mark Knapp ,Elizabeth Ornelas ,Jenny Tang ,Wilian Augusto Cortopassi ,Yu Wang ,Frederick King ,Weiping Jia ,Zachary Nguyen ,Andreas O Frank ,Ryan Chan ,Eric Fang ,Daniel Fuller ,Scott Busby ,Heidi Carias ,Kristine Donahue ,Laura Tandeske ,Thierry T Diagana ,Nadine Jarrousse ,Heinz Moser ,Christopher Sarko ,Dustin Dovala ,Stephanie Moquin ,Vanessa M Marx

Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB

化学蛋白质组学助力发现靶向 NF-κB 的共价分子胶降解剂

Elizabeth A King, Yoojin Cho, Nathan S Hsu, Dustin Dovala, Jeffrey M McKenna, John A Tallarico, Markus Schirle, Daniel K Nomura

Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon

泊马度胺和CC-220诱导的SALL4与cereblon相互作用的结构和生物物理比较

Xiaolei Ma, Barbara Leon, Elizabeth Ornelas, Dustin Dovala, Laura Tandeske, Catherine Luu, Gwynn Pardee, Stephania Widger, Jonathan M Solomon, Rohan E J Beckwith, Heinz Moser, Matthew C Clifton, Charles A Wartchow

Targeted Protein Degradation through E2 Recruitment

通过 E2 募集实现靶向蛋白质降解

Nafsika Forte, Dustin Dovala, Matthew J Hesse, Jeffrey M McKenna, John A Tallarico, Markus Schirle, Daniel K Nomura

Ophiobolin A Covalently Targets Complex IV Leading to Mitochondrial Metabolic Collapse in Cancer Cells

蛇毒蛋白 A 共价靶向复合物 IV,导致癌细胞线粒体代谢崩溃

Flor A Gowans, Danny Q Thach, Yangzhi Wang, Belen E Altamirano Poblano, Dustin Dovala, John A Tallarico, Jeffrey M McKenna, Markus Schirle, Thomas J Maimone, Daniel K Nomura

Deubiquitinase-targeting chimeras for targeted protein stabilization

去泛素化酶靶向嵌合体用于靶向蛋白质稳定

Nathaniel J Henning #, Lydia Boike #, Jessica N Spradlin, Carl C Ward, Gang Liu, Erika Zhang, Bridget P Belcher, Scott M Brittain, Matthew J Hesse, Dustin Dovala, Lynn M McGregor, Rachel Valdez Misiolek, Lindsey W Plasschaert, David J Rowlands, Feng Wang, Andreas O Frank, Daniel Fuller, Abigail R Es

A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes

使用亲电探针评估 E3 连接酶成分针对新底物的细胞活性的策略

Benika J Pinch, Dennis L Buckley, Scott Gleim, Scott M Brittain, Laura Tandeske, Pier Luca D'Alessandro, Zachary J Hauseman, Jennifer Lipps, Lei Xu, Edward P Harvey, Markus Schirle, Elizabeth R Sprague, William C Forrester, Dustin Dovala, Lynn M McGregor, Claudio R Thoma

Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms

SARS-CoV-2 Mpro 的综合适应度景观揭示了病毒耐药机制

Julia M Flynn, Neha Samant, Gily Schneider-Nachum, David T Barkan, Nese Kurt Yilmaz, Celia A Schiffer, Stephanie A Moquin, Dustin Dovala, Daniel N A Bolon

Molecular characterization and verification of azido-3,8-dideoxy-d- manno-oct-2-ulosonic acid incorporation into bacterial lipopolysaccharide

叠氮-3,8-二脱氧-d-甘露-辛-2-乌洛糖酸掺入细菌脂多糖的分子表征和验证

Inga Nilsson, Kerri Grove, Dustin Dovala, Tsuyoshi Uehara, Guillaume Lapointe, David A Six

Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion

底物控制多聚化和 VII 型分泌多结构域 ATPase 马达的激活

Oren S Rosenberg, Dustin Dovala, Xueming Li, Lynn Connolly, Anastasia Bendebury, Janet Finer-Moore, James Holton, Yifan Cheng, Robert M Stroud, Jeffery S Cox