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Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition

FUSR521G 引起的神经元功能障碍会促进 ALS 相关表型，而 NF-κB 抑制可减弱这种表型

Mari Carmen Pelaez, Antoine Desmeules, Pauline A Gelon, Bastien Glasson, Laetitia Marcadet, Alicia Rodgers, Daniel Phaneuf, Silvia Pozzi, Paul A Dutchak, Jean-Pierre Julien, Chantelle F Sephton

信号转导

NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis

NPRL2 抑制 mTORC1 控制钠通道表达和脑氨基酸稳态

期刊:eNeuro

影响因子:2.7

doi:10.1523/ENEURO.0317-21.2022

Jeremy B Hui, Jose Cesar Hernandez Silva, Mari Carmen Pelaez, Myriam Sévigny, Janani Priya Venkatasubramani, Quentin Plumereau, Mohamed Chahine, Christophe D Proulx, Chantelle F Sephton, Paul A Dutchak

FUS contributes to mTOR-dependent inhibition of translation

FUS 有助于 mTOR 依赖的翻译抑制

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1074/jbc.RA120.013801

Myriam Sévigny, Isabelle Bourdeau Julien, Janani Priya Venkatasubramani, Jeremy B Hui, Paul A Dutchak, Chantelle F Sephton

信号转导

FCM

IHC-P

Translational Control

mTOR

发表日期：2020

文献求助收藏

The Severity of Oxidative Stress in Comorbid Chronic Obstructive Pulmonary Disease (COPD) and Hypertension: Does it Depend On ACE and AGT Gene Polymorphisms?

慢性阻塞性肺病 (COPD) 和高血压共病的氧化应激严重程度：是否取决于 ACE 和 AGT 基因多态性？

期刊:Journal of medicine and life

影响因子:

doi:10.25122/jml-2019-0108

Mariya Marushchak, Khrystyna Maksiv, Inna Krynytska, Olha Dutchak, Nina Behosh

Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle

mTORC1负调控因子的缺失会诱导骨骼肌有氧糖酵解并改变肌纤维组成。

期刊:Cell Reports

影响因子:6.9

doi:10.1016/j.celrep.2018.04.058

Dutchak, Paul A; Estill-Terpack, Sandi J; Plec, Abigail A; Zhao, Xiaozheng; Yang, Chendong; Chen, Jun; Ko, Bookyung; Deberardinis, Ralph J; Yu, Yonghao; Tu, Benjamin P

Metabolic Networks Influencing Skeletal Muscle Fiber Composition

影响骨骼肌纤维组成的代谢网络

期刊:Frontiers in Cell and Developmental Biology

影响因子:4.3

doi:10.3389/fcell.2018.00125

Bourdeau Julien, Isabelle; Sephton, Chantelle F; Dutchak, Paul A

代谢

发表日期：2018

文献求助收藏

Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2

mTORC1 抑制剂 NPRL2 对造血和蛋氨酸稳态的调节

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2015.06.042

Paul A Dutchak, Sunil Laxman, Sandi Jo Estill, Chensu Wang, Yun Wang, Yiguang Wang, Gamze B Bulut, Jinming Gao, Lily J Huang, Benjamin P Tu

A modular lentiviral and retroviral construction system to rapidly generate vectors for gene expression and gene knockdown in vitro and in vivo

模块化慢病毒和逆转录病毒构建系统，可快速生成用于体内和体外基因表达和基因敲除的载体

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0076279

Benjamin Geiling, Guillaume Vandal, Ada R Posner, Angeline de Bruyns, Kendall L Dutchak, Samantha Garnett, David Dankort

微生物学

发表日期：2013

文献求助收藏

Emanuel Syndrome: A Case Report With Isolated Nuchal Translucency Thickening

伊曼纽尔综合征：一例孤立性颈项透明层增厚病例报告

GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1

GATOR1 突变会损害 PI3 激酶依赖性生长因子信号对 mTORC1 的调节

Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition

FUSR521G 引起的神经元功能障碍会促进 ALS 相关表型，而 NF-κB 抑制可减弱这种表型

NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis

NPRL2 抑制 mTORC1 控制钠通道表达和脑氨基酸稳态

FUS contributes to mTOR-dependent inhibition of translation

FUS 有助于 mTOR 依赖的翻译抑制

The Severity of Oxidative Stress in Comorbid Chronic Obstructive Pulmonary Disease (COPD) and Hypertension: Does it Depend On ACE and AGT Gene Polymorphisms?

慢性阻塞性肺病 (COPD) 和高血压共病的氧化应激严重程度：是否取决于 ACE 和 AGT 基因多态性？

Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle

mTORC1负调控因子的缺失会诱导骨骼肌有氧糖酵解并改变肌纤维组成。

Metabolic Networks Influencing Skeletal Muscle Fiber Composition

影响骨骼肌纤维组成的代谢网络

Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2

mTORC1 抑制剂 NPRL2 对造血和蛋氨酸稳态的调节

A modular lentiviral and retroviral construction system to rapidly generate vectors for gene expression and gene knockdown in vitro and in vivo

模块化慢病毒和逆转录病毒构建系统，可快速生成用于体内和体外基因表达和基因敲除的载体