Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the MIR141/MIR200C-ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cells
全基因组表观遗传和 mRNA 表达谱分析以及随后的 CRISPR/Cas9 介导的基因破坏证实了 MIR141/MIR200C-ZEB1/ZEB2-FGFR1 轴在 NSCLC 细胞中获得性 EMT 相关 EGFR TKI 耐药性中的作用
期刊:Translational Lung Cancer Research
影响因子:4
doi:10.21037/tlcr-22-507
Johan Vad-Nielsen, Nicklas Heine Staunstrup, Magnus Lindkvist Kjeldsen, Nina Dybdal, Guillaume Flandin, Claudia De Stradis, Tina Fuglsang Daugaard, Trine Vilsbøll-Larsen, Christoffer Trier Maansson, Thomas Koed Doktor, Boe Sandahl Sorensen, Anders Lade Nielsen