日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

What does BCL-2 do? From new molecular insights to the clinical implications

BCL-2 有什么作用?从新的分子机制到临床意义

Croce, Carlo M; Tait, Stephen W G; Garcia-Sáez, Ana J; Villunger, Andreas; Letai, Anthony; Walter, Harriet S; Dyer, Martin J S; Green, Douglas R; Shi, Yufang; Melino, Gerry

Chronic lymphocytic leukemia with IGH::BCL3-translocation is characterized by a homogeneous and distinct genetic and epigenetic landscape

伴有IGH::BCL3易位的慢性淋巴细胞白血病具有同质且独特的遗传和表观遗传特征。

Drewes, Cosima; López, Cristina; Martinez-Manjón, Juan Emilio; Okeke, Nnamdi; Jebaraj, Billy; Bens, Susanne; Brändl, Björn; Dyer, Martin J S; Eichhorst, Barbara; Fischer, Anja; Fischer, Kirsten; Robrecht, Sandra; Hallek, Michael; Glaser, Selina; Hillebrecht, Sina; Jayne, Sandrine; Kretzmer, Helene; Mottok, Anja; Müller, Franz-Josef; Schneider, Christof; Ammerpohl, Ole; Del Val, Coral; Stilgenbauer, Stephan; Tausch, Eugen; Siebert, Reiner

The BH3-only protein NOXA is essential for apoptosis induction by BH3-mimetics targeting BCL2 or BCL-X(L) in DLBCL

BH3结构域蛋白NOXA对于靶向BCL2或BCL-X(L)的BH3模拟物在弥漫性大B细胞淋巴瘤(DLBCL)中诱导细胞凋亡至关重要。

Yildirim, Nahide; Anders, Marius; Smith, Victoria M; Jayne, Sandrine; Assmann, Moritz; Jukes-Jones, Rebekah; Dyer, Martin J S; Vogler, Meike

The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy

BCL2家族:从细胞凋亡机制到靶向治疗的新进展

Vogler, Meike; Braun, Yannick; Smith, Victoria M; Westhoff, Mike-Andrew; Pereira, Raquel S; Pieper, Nadja M; Anders, Marius; Callens, Manon; Vervliet, Tim; Abbas, Maha; Macip, Salvador; Schmid, Ralf; Bultynck, Geert; Dyer, Martin Js

Long-term outcomes of chemoimmunotherapy with obinutuzumab/chlorambucil in chronic lymphocytic leukemia

奥妥珠单抗/苯丁酸氮芥化疗免疫疗法治疗慢性淋巴细胞白血病的长期疗效

Goede, Valentin; Fischer, Kirsten; Robrecht, Sandra; Giza, Adam; Dyer, Martin J S; Eckart, Michael J; Mϋller, Lothar; Smolej, Lukáš; Kutsch, Nadine; Fink, Anna-Maria; Stilgenbauer, Stephan; Hallek, Michael

The unfolded protein response influences therapy outcome and disease progression in chronic lymphocytic leukaemia.

未折叠蛋白反应影响慢性淋巴细胞白血病的治疗结果和疾病进展

Khan Umair Tahir, Clarke Kim, Eagle Gina, Oates Melanie, Hillmen Peter, Jayne Sandrine, Dyer Martin J S, Phipps Alex, Falciani Francesco, Jenkins Rosalind E, Pettitt Andrew R

In vitro comparison of CD20xCD3 bispecific antibodies against diffuse large B-cell lymphoma (DLBCL) cell lines with different levels of expression of CD20

体外比较CD20×CD3双特异性抗体对不同CD20表达水平的弥漫性大B细胞淋巴瘤(DLBCL)细胞系的活性

Bray, Joshua S; Thomas, Gethin R; Smith, Victoria M; Wright, Adam; Jayne, Sandrine; Dyer, Martin J S; Walter, Harriet S

Targeted Degradation of Class 1 HDACs With PROTACs is Highly Effective at Inducing DLBCL Cell Death.

利用 PROTACs 靶向降解 1 类 HDACs 可高效诱导 DLBCL 细胞死亡

Alraddadi Abdullah, Smalley Joshua P, Alzahrani Wael, Saleh Anes, Al-Mansour Fares, He Buwei, Cao Thong H, Jayne Sandrine, Dyer Martin, Hodgkinson James T, Jones Donald J L, Cowley Shaun M, Macip Salvador

Heavy-element production in a compact object merger observed by JWST

詹姆斯·韦伯太空望远镜观测到致密天体并合过程中重元素的产生。

Levan, Andrew J; Gompertz, Benjamin P; Salafia, Om Sharan; Bulla, Mattia; Burns, Eric; Hotokezaka, Kenta; Izzo, Luca; Lamb, Gavin P; Malesani, Daniele B; Oates, Samantha R; Ravasio, Maria Edvige; Rouco Escorial, Alicia; Schneider, Benjamin; Sarin, Nikhil; Schulze, Steve; Tanvir, Nial R; Ackley, Kendall; Anderson, Gemma; Brammer, Gabriel B; Christensen, Lise; Dhillon, Vikram S; Evans, Phil A; Fausnaugh, Michael; Fong, Wen-Fai; Fruchter, Andrew S; Fryer, Chris; Fynbo, Johan P U; Gaspari, Nicola; Heintz, Kasper E; Hjorth, Jens; Kennea, Jamie A; Kennedy, Mark R; Laskar, Tanmoy; Leloudas, Giorgos; Mandel, Ilya; Martin-Carrillo, Antonio; Metzger, Brian D; Nicholl, Matt; Nugent, Anya; Palmerio, Jesse T; Pugliese, Giovanna; Rastinejad, Jillian; Rhodes, Lauren; Rossi, Andrea; Saccardi, Andrea; Smartt, Stephen J; Stevance, Heloise F; Tohuvavohu, Aaron; van der Horst, Alexander; Vergani, Susanna D; Watson, Darach; Barclay, Thomas; Bhirombhakdi, Kornpob; Breedt, Elmé; Breeveld, Alice A; Brown, Alexander J; Campana, Sergio; Chrimes, Ashley A; D'Avanzo, Paolo; D'Elia, Valerio; De Pasquale, Massimiliano; Dyer, Martin J; Galloway, Duncan K; Garbutt, James A; Green, Matthew J; Hartmann, Dieter H; Jakobsson, Páll; Kerry, Paul; Kouveliotou, Chryssa; Langeroodi, Danial; Le Floc'h, Emeric; Leung, James K; Littlefair, Stuart P; Munday, James; O'Brien, Paul; Parsons, Steven G; Pelisoli, Ingrid; Sahman, David I; Salvaterra, Ruben; Sbarufatti, Boris; Steeghs, Danny; Tagliaferri, Gianpiero; Thöne, Christina C; de Ugarte Postigo, Antonio; Kann, David Alexander

The chromosomal translocation t(1;6)(p35.3;p25.2), recurrent in chronic lymphocytic leukaemia, leads to RCC1::IRF4 fusion

慢性淋巴细胞白血病中常见的染色体易位t(1;6)(p35.3;p25.2)会导致RCC1::IRF4融合。

Jayne, Sandrine; López, Cristina; Put, Natalie; Nagel, Inga; Lierman, Els; Penas, Eva Maria Murga; Michaux, Lucienne; Ahearne, Matthew J; Walter, Harriet S; Bens, Susanne; Drewes, Cosima; Szczepanowski, Monika; Schlesner, Matthias; Rosenstiel, Philip; Wlodarska, Iwona; Siebert, Reiner; Dyer, Martin J S