日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective remodelling of the adipose niche in obesity and weight loss

肥胖和体重减轻中脂肪微环境的选择性重塑

Antonio M A Miranda ,Liam McAllan ,Guianfranco Mazzei ,Ivan Andrew ,Iona Davies ,Meryem Ertugrul ,Julia Kenkre ,Hiromi Kudo ,Joana Carrelha ,Bhavik Patel ,Sophie Newton ,Weihua Zhang ,Alice Pollard ,Amy Cross ,Oliver McCallion ,Mikyung Jang ,Ka Lok Choi ,Scarlett Brown ,Yasmin Rasool ,Marco Adamo ,Mohamed Elkalaawy ,Andrew Jenkinson ,Borzoueh Mohammadi ,Majid Hashemi ,Robert Goldin ,Laurence Game ,Joanna Hester ,Fadi Issa ,Dylan G Ryan ,Patricia Ortega ,Ahmed R Ahmed ,Rachel L Batterham ,John C Chambers ,Jaspal S Kooner ,Damir Baranasic ,Michela Noseda ,Tricia Tan ,William R Scott

Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation

促炎巨噬细胞通过复合物 I 的逆向电子传递产生线粒体来源的超氧化物,该超氧化物在 NLRP3 炎症小体激活过程中调节 IL-1β 的释放。

Alva M Casey ,Dylan G Ryan ,Hiran A Prag ,Suvagata Roy Chowdhury ,Eloïse Marques ,Keira Turner ,Anja V Gruszczyk ,Ming Yang ,Dane M Wolf ,Jan Lj Miljkovic ,Joyce Valadares ,Patrick F Chinnery ,Richard C Hartley ,Christian Frezza ,Julien Prudent ,Michael P Murphy

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice

一种遗传性线粒体DNA突变可重塑巨噬细胞和小鼠体内的炎症细胞因子反应。

Eloïse Marques ,Stephen P Burr ,Alva M Casey ,Richard J Stopforth ,Chak Shun Yu ,Keira Turner ,Dane M Wolf ,Marisa Dilucca ,Vincent Paupe ,Suvagata Roy Chowdhury ,Victoria J Tyrrell ,Robbin Kramer ,Yamini M Kanse ,Chinmayi Pednekar ,Chris A Powell ,James B Stewart ,Julien Prudent ,Michael P Murphy ,Michal Minczuk ,Valerie B O'Donnell ,Clare E Bryant ,Patrick F Chinnery ,Arthur Kaser ,Alexander von Kriegsheim ,Dylan G Ryan

Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion

线粒体呼吸链复合物III维持活化巨噬细胞中IL-10的产生,并促进肿瘤介导的免疫逃逸。

Alessia Zotta ,Juliana Toller-Kawahisa ,Eva M Palsson-McDermott ,Shane M O'Carroll ,Órlaith C Henry ,Emily A Day ,Anne F McGettrick ,Ross W Ward ,Dylan G Ryan ,Mark A Watson ,Martin D Brand ,Marah C Runtsch ,Kathrin Maitz ,Anna Lueger ,Julia Kargl ,Jan L Miljkovic ,Ed C Lavelle ,Luke A J O'Neill

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

巨噬细胞富马酸水合酶抑制线粒体RNA介导的干扰素产生

Alexander Hooftman # ,Christian G Peace # ,Dylan G Ryan # ,Emily A Day ,Ming Yang ,Anne F McGettrick ,Maureen Yin ,Erica N Montano ,Lihong Huo ,Juliana E Toller-Kawahisa ,Vincent Zecchini ,Tristram A J Ryan ,Alfonso Bolado-Carrancio ,Alva M Casey ,Hiran A Prag ,Ana S H Costa ,Gabriela De Los Santos ,Mariko Ishimori ,Daniel J Wallace ,Swamy Venuturupalli ,Efterpi Nikitopoulou ,Norma Frizzell ,Cecilia Johansson ,Alexander Von Kriegsheim ,Michael P Murphy ,Caroline Jefferies ,Christian Frezza ,Luke A J O'Neill

Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response

Nrf2激活可重编程巨噬细胞中间代谢并抑制I型干扰素反应。

Dylan G Ryan ,Elena V Knatko ,Alva M Casey ,Jens L Hukelmann ,Sharadha Dayalan Naidu ,Alejandro J Brenes ,Thanapon Ekkunagul ,Christa Baker ,Maureen Higgins ,Laura Tronci ,Efterpi Nikitopolou ,Tadashi Honda ,Richard C Hartley ,Luke A J O'Neill ,Christian Frezza ,Angus I Lamond ,Andrey Y Abramov ,J Simon C Arthur ,Doreen A Cantrell ,Michael P Murphy ,Albena T Dinkova-Kostova

Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages

信号代谢物 L-2-羟基戊二酸激活脂多糖激活巨噬细胞中的转录因子 HIF-1α

Niamh C Williams, Dylan G Ryan, Ana S H Costa, Evanna L Mills, Mark P Jedrychowski, Suzanne M Cloonan, Christian Frezza, Luke A O'Neill

DIA label-free proteomic analysis of murine bone-marrow-derived macrophages

小鼠骨髓来源巨噬细胞的 DIA 无标记蛋白质组学分析

Christa P Baker, Iain R Phair, Alejandro J Brenes, Abdelmadjid Atrih, Dylan G Ryan, Roland Bruderer, Albena T Dinkova-Kostova, Douglas J Lamont, J Simon C Arthur, Andrew J M Howden

Caspase-11 promotes allergic airway inflammation

Caspase-11促进过敏性呼吸道炎症

Zbigniew Zasłona, Ewelina Flis, Mieszko M Wilk, Richard G Carroll, Eva M Palsson-McDermott, Mark M Hughes, Ciana Diskin, Kathy Banahan, Dylan G Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J McElvaney, Kingston H G Mills

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

衣康酸是一种抗炎代谢物,可通过 KEAP1 烷基化激活 Nrf2

Evanna L Mills, Dylan G Ryan, Hiran A Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P Jedrychowski, Ana S H Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C Runtsch, Martin S King, Joanna F McGouran, Roman Fischer, Benedikt M Kessler, Anne F McGettrick, Mark M Hughes, Richard G