日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease

在阿尔茨海默病小鼠模型中,血管周围细胞通过SPP1诱导小胶质细胞的吞噬状态和突触吞噬作用。

Sebastiaan De Schepper ,Judy Z Ge ,Gerard Crowley ,Laís S S Ferreira ,Dylan Garceau ,Christina E Toomey ,Dimitra Sokolova ,Javier Rueda-Carrasco ,Sun-Hye Shin ,Jung-Seok Kim ,Thomas Childs ,Tammaryn Lashley ,Jemima J Burden ,Michael Sasner ,Carlo Sala Frigerio ,Steffen Jung ,Soyon Hong

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

新型应用程序敲入小鼠模型展现了淀粉样蛋白病理的关键特征,并揭示了小胶质细胞严重的代谢紊乱。

Dan Xia # ,Steve Lianoglou # ,Thomas Sandmann ,Meredith Calvert ,Jung H Suh ,Elliot Thomsen ,Jason Dugas ,Michelle E Pizzo ,Sarah L DeVos ,Timothy K Earr ,Chia-Ching Lin ,Sonnet Davis ,Connie Ha ,Amy Wing-Sze Leung ,Hoang Nguyen ,Roni Chau ,Ernie Yulyaningsih ,Isabel Lopez ,Hilda Solanoy ,Shababa T Masoud ,Chun-Chi Liang ,Karin Lin ,Giuseppe Astarita ,Nathalie Khoury ,Joy Yu Zuchero ,Robert G Thorne ,Kevin Shen ,Stephanie Miller ,Jorge J Palop ,Dylan Garceau ,Michael Sasner ,Jennifer D Whitesell ,Julie A Harris ,Selina Hummel ,Johannes Gnörich ,Karin Wind ,Lea Kunze ,Artem Zatcepin ,Matthias Brendel ,Michael Willem ,Christian Haass ,Daniel Barnett ,Till S Zimmer ,Anna G Orr ,Kimberly Scearce-Levie ,Joseph W Lewcock ,Gilbert Di Paolo ,Pascal E Sanchez

Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H

揭示表达人源化 APOEε4 和 Trem2*R47H 的新型小鼠模型中的疾病机制

Kevin P Kotredes, Adrian Oblak, Ravi S Pandey, Peter Bor-Chian Lin, Dylan Garceau, Harriet Williams, Asli Uyar, Rita O'Rourke, Sarah O'Rourke, Cynthia Ingraham, Daria Bednarycek, Melisa Belanger, Zackary Cope, Kate E Foley, Benjamin A Logsdon, Lara M Mangravite, Stacey J Sukoff Rizzo, Paul R Territo

Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study

5XFAD 小鼠模型在临床前测试应用方面的综合评估:MODEL-AD 研究

Adrian L Oblak, Peter B Lin, Kevin P Kotredes, Ravi S Pandey, Dylan Garceau, Harriet M Williams, Asli Uyar, Rita O'Rourke, Sarah O'Rourke, Cynthia Ingraham, Daria Bednarczyk, Melisa Belanger, Zackary A Cope, Gabriela J Little, Sean-Paul G Williams, Carl Ash, Adam Bleckert, Tim Ragan, Benjamin A Logs

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease

一种评估晚发性阿尔茨海默病小鼠模型的新型系统生物学方法

Christoph Preuss, Ravi Pandey, Erin Piazza, Alexander Fine, Asli Uyar, Thanneer Perumal, Dylan Garceau, Kevin P Kotredes, Harriet Williams, Lara M Mangravite, Bruce T Lamb, Adrian L Oblak, Gareth R Howell, Michael Sasner, Benjamin A Logsdon; MODEL-AD Consortium; Gregory W Carter