日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanistic insights into dual-active liver and blood-stage antiplasmodials

对具有双重活性的肝期和血期抗疟药物的机制研究

Rawat, Mukul; Boonyalai, Nonlawat; Smidt, Cindy; Luth, Madeline R; Chen, Daisy; Plater, Andrew; Post, John; Lin, De; McMillan, Joel; Eadsforth, Thomas; Moliner-Cubel, Sonia; Billker, Oliver; Rayner, Julian C; Gamo, Fransisco-Javier; Baragaña, Beatriz; Winzeler, Elizabeth A; Lee, Marcus C S

Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase

冠状病毒nsp14甲基转移酶双底物抑制剂的晶体学表征和开发

Georgiou, Irene; Robinson, Colin; O'Byrne, Sean N; Matsuda, Alex; Grygier, Przemysław; Smith, Craig D; O'Neill, Sandra; Ahmad, Shamshad A; Norval, Suzanne; Post, John M; Groenewold, Mirjam; Urakova, Nadya; Wanningen, Patrick; Kresik, Leanid; Plewka, Jacek; Delpal, Adrien; See, Kexin; Eadsforth, Thomas; Wierzbicka, Kinga; Decroly, Etienne; Saikatendu, Kumar Singh; Chang, Edcon; Snijder, Eric J; Pyrć, Krzysztof; Czarna, Anna; Scott, Duncan E; Gilbert, Ian H

Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach

利用小分子方法对RNA鸟嘌呤-7甲基转移酶(RNMT)进行表征

Pearson, Lesley-Anne; Petit, Alain-Pierre; Mendoza Martinez, Cesar; Bellany, Fiona; Lin, De; Niven, Sarah; Swift, Rachel; Eadsforth, Thomas; Fyfe, Paul; Paul, Marilyn; Postis, Vincent; Hu, Xiao; Cowling, Victoria H; Gray, David W

Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors

对克氏锥虫蛋白酶体的药理学和结构理解为开发位点特异性抑制剂提供了关键见解

Thomas C Eadsforth, Leah S Torrie, Paul Rowland, Emma V Edgar, Lorna M MacLean, Christy Paterson, David A Robinson, Sharon M Shepherd, John Thomas, Michael G Thomas, David W Gray, Vincent L G Postis, Manu De Rycker

Mechanistic Insights into Dual-Active Liver and Blood-Stage Antiplasmodials.

对具有双重活性的肝期和血期抗疟药物的机制研究

Rawat Mukul, Boonyalai Nonlawat, Smidt Cindy, Luth Madeline R, Chen Daisy, Plater Andrew, Post John, Lin De, McMillan Joel, Eadsforth Thomas, Moliner-Cubel Sonia, Billker Oliver, Rayner Julian C, Gamo Francisco-Javier, Baragaña Beatriz, Winzeler Elizabeth A, Lee Marcus C S

Structural determination of oleanane-28,13β-olide and taraxerane-28,14β-olide fluoro-lactonization products from the reaction of oleanolic acid with Selectfluor(TM).

通过齐墩果酸与 Selectfluor(TM) 的反应,确定齐墩果烷-28,13β-内酯和蒲公英烷-28,14β-内酯氟化产物的结构

Eadsforth Megan A, Kong Linghan, Whitehead George, Vitórica-Yrezábal Iñigo J, O'Keefe Raymond T, Bryce Richard A, Whitehead Roger C

Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity

鉴定和优化具有抗结核活性的新型聚酮合酶13硫酯酶结构域抑制剂

Green, Simon R; Wilson, Caroline; Eadsforth, Thomas C; Punekar, Avinash S; Tamaki, Fabio K; Wood, Gavin; Caldwell, Nicola; Forte, Barbara; Norcross, Neil R; Kiczun, Michael; Post, John M; Lopez-Román, Eva Maria; Engelhart, Curtis A; Lukac, Iva; Zuccotto, Fabio; Epemolu, Ola; Boshoff, Helena I M; Schnappinger, Dirk; Walpole, Chris; Gilbert, Ian H; Read, Kevin D; Wyatt, Paul G; Baragaña, Beatriz

The Role of the U5 snRNP in Genetic Disorders and Cancer

U5 snRNP在遗传疾病和癌症中的作用

Wood, Katherine A; Eadsforth, Megan A; Newman, William G; O'Keefe, Raymond T

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

利用基于生物传感器的分子片段库筛选鉴定利什曼原虫UDP-糖焦磷酸化酶抑制剂

Prakash, Ohm; Führing, Jana; Post, John; Shepherd, Sharon M; Eadsforth, Thomas C; Gray, David; Fedorov, Roman; Routier, Françoise H

Mirror-Image Packing Provides a Molecular Basis for the Nanomolar Equipotency of Enantiomers of an Experimental Herbicide

镜像堆积为实验除草剂对映异构体的纳摩尔等效性提供了分子基础

Bisson, Claudine; Britton, K Linda; Sedelnikova, Svetlana E; Rodgers, H Fiona; Eadsforth, Thomas C; Viner, Russell C; Hawkes, Tim R; Baker, Patrick J; Rice, David W