日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting the host transcription factor HSF1 prevents human cytomegalovirus replication in vitro and in vivo

靶向宿主转录因子HSF1可抑制人巨细胞病毒在体外和体内的复制。

Akter, Dilruba; Biswas, Juthi; Moradpour, Shima; Carter, Meghan F; Miller, Michael J; Thiele, Dennis J; Murphy, Eain A; O'Connor, Christine M; Moffat, Jennifer F; Chan, Gary C

Generation of a panel of mutants that are resistant to standard of care therapies in a clinically relevant strain of human cytomegalovirus for drug resistance profiling

构建一组对临床相关人巨细胞病毒株的标准治疗方案具有耐药性的突变株,用于药物耐药性分析。

Carter, Meghan F; Knight, Kassidy; Kayode, Yetunde; Murphy, Eain A

Protein-S-nitrosylation of adenovirus-5 E1A and human papillomavirus 16 E7 limits their ability to inhibit STING activity

腺病毒5型E1A蛋白和人乳头瘤病毒16型E7蛋白的S-亚硝基化作用限制了它们抑制STING活性的能力。

Cox, Justin B; Murphy, Eain A

Protein-S-nitrosylation of human cytomegalovirus pp65 reduces its ability to undermine cGAS

人巨细胞病毒pp65蛋白的S-亚硝基化作用降低了其破坏cGAS的能力。

Cox, Justin B; Nukui, Masatoshi; Murphy, Eain A

Herpes simplex virus-1 targets the 2'-3'cGAMP importer SLC19A1 as an antiviral countermeasure

单纯疱疹病毒1型靶向2'-3'cGAMP输入蛋白SLC19A1作为一种抗病毒对抗措施

Szemere, Zsuzsa K; Ijezie, Emmanuel; Murphy, Eain A

Import of extracellular 2'-3'cGAMP by the folate transporter, SLC19A1, establishes an antiviral response that limits herpes simplex virus-1

叶酸转运蛋白SLC19A1介导胞外2'-3'cGAMP的输入,从而建立起一种抗病毒反应,限制单纯疱疹病毒1型(HSV-1)的复制。

Szemere, Zsuzsa K; Murphy, Eain A

The effective multiplicity of infection for HCMV depends on activity of the cellular 20S proteasome

HCMV的有效感染复数取决于细胞20S蛋白酶体的活性。

Cataldo, Katie M; Roche, Kathryn L; Monti, Christopher E; Dash, Ranjan K; Murphy, Eain A; Terhune, Scott S

An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity

sirtuin 2 去乙酰化酶活性的变构抑制剂具有广谱抗病毒活性

Kathryn L Roche, Stacy Remiszewski, Matthew J Todd, John L Kulp 3rd, Liudi Tang, Alison V Welsh, Ashley P Barry, Chandrav De, William W Reiley, Angela Wahl, J Victor Garcia, Micah A Luftig, Thomas Shenk, James R Tonra, Eain A Murphy, Lillian W Chiang

Design of a US28 ORF Deletion Virus in a Temperature-Sensitive Cytomegalovirus Strain Fails to Promote Lytic Replication in Hematopoietic Cells

温度敏感型巨细胞病毒株中 US28 ORF 缺失病毒的设计无法促进造血细胞中的裂解复制

Benjamin A Krishna, Amanda B Wass, Eain A Murphy, Christine M O'Connor

A Viral Long Non-Coding RNA Protects against Cell Death during Human Cytomegalovirus Infection of CD14+ Monocytes

病毒长链非编码 RNA 在人类巨细胞病毒感染 CD14+ 单核细胞期间保护细胞免于死亡

Marianne R Perera, Kathryn L Roche, Eain A Murphy, John H Sinclair