日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase

双环氮杂环丁烷通过抑制寄生虫苯丙氨酰 t-RNA 合成酶来靶向弓形虫的急性和慢性阶段

Joshua B Radke, Bruno Melillo, Payal Mittal, Manmohan Sharma, Amit Sharma, Yong Fu, Taher Uddin, Arthur Gonse, Eamon Comer, Stuart L Schreiber, Anil K Gupta, Arnab K Chatterjee, L David Sibley

Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines

双环氮杂环丁烷抑制疟原虫苯丙氨酸 tRNA 合成酶的结构基础

Manmohan Sharma, Nipun Malhotra, Manickam Yogavel, Karl Harlos, Bruno Melillo, Eamon Comer, Arthur Gonse, Suhel Parvez, Branko Mitasev, Francis G Fang, Stuart L Schreiber, Amit Sharma

Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures

四环素通过靶向关键的人类 rRNA 亚结构来修改翻译

Jonathan D Mortison, Monica Schenone, Jacob A Myers, Ziyang Zhang, Linfeng Chen, Christie Ciarlo, Eamon Comer, S Kundhavai Natchiar, Steven A Carr, Bruno P Klaholz, Andrew G Myers

High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth

高通量筛选鉴定出干扰素γ依赖性的弓形虫生长抑制剂

Joshua B Radke, Kimberly L Carey, Subrata Shaw, Shailesh R Metkar, Carol Mulrooney, Jennifer P Gale, Joshua A Bittker, Robert Hilgraf, Eamon Comer, Stuart L Schreiber, Herbert W Virgin, Jose R Perez, L David Sibley

Novel tricyclic glycal-based TRIB1 inducers that reprogram LDL metabolism in hepatic cells

新型三环糖基 TRIB1 诱导剂可重编程肝细胞中的 LDL 代谢

Marek M Nagiec, Jeremy R Duvall, Adam P Skepner, Eleanor A Howe, Jessica Bastien, Eamon Comer, Jean-Charles Marie, Stephen E Johnston, Joseph Negri, Michelle Eichhorn, Julien Vantourout, Clary Clish, Kiran Musunuru, Michael Foley, Jose R Perez, Michelle A J Palmer

High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria

基于高通量荧光素酶的检测方法用于发现预防疟疾的治疗方法

Justine Swann, Victoria Corey, Christina A Scherer, Nobutaka Kato, Eamon Comer, Micah Maetani, Yevgeniya Antonova-Koch, Christin Reimer, Kerstin Gagaring, Maureen Ibanez, David Plouffe, Anne-Marie Zeeman, Clemens H M Kocken, Case W McNamara, Stuart L Schreiber, Brice Campo, Elizabeth A Winzeler, Ste

Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression

在寻找三联假激酶 1 表达的小分子诱导剂时发现肝脏脂蛋白代谢的调节剂

Marek M Nagiec, Adam P Skepner, Joseph Negri, Michelle Eichhorn, Nicolas Kuperwasser, Eamon Comer, Giovanni Muncipinto, Aravind Subramanian, Clary Clish, Kiran Musunuru, Jeremy R Duvall, Michael Foley, Jose R Perez, Michelle A J Palmer

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

来那度胺导致多发性骨髓瘤细胞中 IKZF1 和 IKZF3 选择性降解

Jan Krönke, Namrata D Udeshi, Anupama Narla, Peter Grauman, Slater N Hurst, Marie McConkey, Tanya Svinkina, Dirk Heckl, Eamon Comer, Xiaoyu Li, Christie Ciarlo, Emily Hartman, Nikhil Munshi, Monica Schenone, Stuart L Schreiber, Steven A Carr, Benjamin L Ebert