日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Characterization of Novel Sigma Receptor Ligands Derived from Multicomponent Reactions as Efficacious Treatments for Neuropathic Pain

表征源自多组分反应的新型σ受体配体作为治疗神经性疼痛的有效方法

Shinouchi, Ryosuke; Turgutalp, Bengisu; Ople, Rohini S; Eans, Shainnel O; Williams, Ashai K; Hammond, Haylee R; Varadi, Andras; Dardashti, Rebecca Notis; Majumdar, Susruta; McLaughlin, Jay P

Structure-guided design of partial agonists at an opioid receptor.

基于结构的阿片受体部分激动剂设计

Varga Balazs R, Bernhard Sarah M, El Daibani Amal, Zaidi Saheem A, Lam Jordy H, Aguilar Jhoan, Appourchaux Kevin, Nazarova Antonina L, Kouvelis Alexa, Shinouchi Ryosuke, Hammond Haylee R, Eans Shainnel O, Weinreb Violetta, Margolis Elyssa B, Fay Jonathan F, Huang Xi-Ping, Pradhan Amynah, Katritch Vsevolod, McLaughlin Jay P, Majumdar Susruta, Che Tao

Total synthesis and biological activity of "carbamorphine": O-to-CH(2) replacement in the E-ring of the morphine core structure.

“卡巴吗啡”的全合成及生物活性:吗啡核心结构E环中的O-到-CH(2)取代

Akiyama Sota, Ople Rohini S, Kremsmair Alexander, Ramos-Gonzalez Nokomis, Nedungadan Thomas, Kennedy Brandon J, Appourchaux Kevin, Eans Shainnel O, Tsai Bowen A, Kraml Christina, Huang Xi-Ping, McLaughlin Jay P, Majumdar Susruta, Sarpong Richmond

Dual Opioid-Neuropeptide FF Small Molecule Ligands Demonstrate Analgesia with Reduced Tolerance Liabilities

双重阿片-神经肽FF小分子配体表现出镇痛作用,且耐受性降低

Mottinelli, Marco; Journigan, V Blair; Obeng, Samuel; Pallares, Victoria L C; Mѐsangeau, Christophe; Kapanda, Coco N; Cutler, Stephen J; Lambert, Janet A; Eans, Shainnel O; Ganno, Michelle L; Sheng, Wanhui; King, Tamara; Sharma, Abhisheak; Mollereau, Catherine; Avery, Bonnie A; McLaughlin, Jay P; McCurdy, Christopher R

Optimization of the Macrocyclic Tetrapeptide [D-Trp]CJ-15,208 to Prevent Stress-Induced Relapse of Cocaine-Seeking Behavior

优化大环四肽[D-Trp]CJ-15,208以预防应激诱导的可卡因渴求行为复发

Aldrich, Jane V; Yakovlev, Dmitry Y; Coleman, Jeremy S; Senadheera, Sanjeewa N; Stacy, Heather M; Eans, Shainnel O; Knapp, Brian I; Bidlack, Jean M; McLaughlin, Jay P

Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics

外周限制性稠合杂环肽模拟多功能阿片激动剂作为新型强效镇痛药

Hammond, Haylee R; Chaudhari, Prakash; Bunnell, Ashley; Nefzi, Khadija; Chen, Chongguang; Zhao, Pingwei; Eans, Shainnel O; Masood, Sabrina R; Dooley, Colette T; Liu-Chen, Lee-Yuan; McLaughlin, Jay P; Nefzi, Adel

Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic.

吗啡烷衍生的双重μ-κ阿片受体激动剂镇痛药的合成与药理学研究

Varga Balazs R, Uprety Rajendra, Paul Barnali, Knoll Alexis, Ramos-Gonzalez Nokomis, Appourchaux Kevin, Taylor Tori, Turgutalp Bengisu, Shinouchi Ryosuke, Eans Shainnel O, Williams Ashai K, Vasquez-Grinnell Steven G, Zaidi Saheem, Nazarova Antonina L, Varadi Andras, Le Rouzic Valerie, Brown Taylor G, Martinez Shani, Ansonoff Michael, Dardashti Rebecca Notis, Hunkele Amanda, Subrath Joan, Welch Matthew, Xu Jin, Rossi Grace C, Pintar John, Pasternak Gavril W, Katritch Vsevolod, McLaughlin Jay P, Pan Ying Xian, Majumdar Susruta

A µ-opioid receptor modulator that works cooperatively with naloxone.

一种与纳洛酮协同作用的μ-阿片受体调节剂

O'Brien Evan S, Rangari Vipin Ashok, El Daibani Amal, Eans Shainnel O, Hammond Haylee R, White Elizabeth, Wang Haoqing, Shiimura Yuki, Krishna Kumar Kaavya, Jiang Qianru, Appourchaux Kevin, Huang Weijiao, Zhang Chensong, Kennedy Brandon J, Mathiesen Jesper M, Che Tao, McLaughlin Jay P, Majumdar Susruta, Kobilka Brian K

Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR

配体与μ阿片受体钠位点的水分子相互作用介导的信号调控

Ople, Rohini S; Ramos-Gonzalez, Nokomis; Li, Qiongyu; Sobecks, Briana L; Aydin, Deniz; Powers, Alexander S; Faouzi, Abdelfattah; Polacco, Benjamin J; Bernhard, Sarah M; Appourchaux, Kevin; Sribhashyam, Sashrik; Eans, Shainnel O; Tsai, Bowen A; Dror, Ron O; Varga, Balazs R; Wang, Haoqing; Hüttenhain, Ruth; McLaughlin, Jay P; Majumdar, Susruta

Association of copeptin levels with patient prognosis and survival in sepsis syndromes: a meta-analysis

脓毒症综合征中血管加压素原水平与患者预后和生存率的关系:一项荟萃分析

Bhattarai, Abhinav; Shah, Sangam; Baidya, Sujata; Thapa, Ranjana; Bhandari, Suyog; Tuladhar, Eans T; Acharya, Subhash P; Sah, Ranjit