日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse model

在早期发育过程中,血脑屏障处转铁蛋白受体介导的转运水平升高,并在衰老过程中以及阿尔茨海默病小鼠模型中维持稳定。

Vanessa O Torres ,Michelle E Pizzo ,Darren Chan ,Jason C Dugas ,David Huynh ,David Joy ,Eric K Liang ,Lily Sarrafha ,Isabel Becerra ,Roni Chau ,Kylie S Chew ,Johann Chow ,Claire B Discenza ,Timothy K Earr ,Laura Furaso ,Nathalie Khoury ,Kendra J Lechtenberg ,Amy W Leung ,Hoang N Nguyen ,Emmanuel S Ojo ,Elysia Roche ,Matthew J Simon ,Hilda Solanoy ,Mabel Tong ,Raymond K Tong ,Kirk Henne ,Joseph W Lewcock ,Ryan J Watts ,Meredith E Calvert ,Robert G Thorne ,Y Joy Yu Zuchero

DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

DNL343 是一种在研的中枢神经系统渗透性真核起始因子 2B 激活剂,可预防和逆转由综合应激反应引起的神经退行性的影响

Ernie Yulyaningsih #, Jung H Suh, Melania Fanok #, Roni Chau, Hilda Solanoy, Ryan Takahashi, Anna I Bakardjiev, Isabel Becerra, N Butch Benitez, Chi-Lu Chiu, Sonnet S Davis, William E Dowdle, Timothy Earr, Anthony A Estrada, Audrey Gill, Connie Ha, Patrick C G Haddick, Kirk R Henne, Martin Larhammar

A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models

一种带有血脑屏障转运载体的TREM2激活抗体可增强阿尔茨海默病模型中的小胶质细胞代谢。

Bettina van Lengerich # ,Lihong Zhan # ,Dan Xia # ,Darren Chan ,David Joy ,Joshua I Park ,David Tatarakis ,Meredith Calvert ,Selina Hummel ,Steve Lianoglou ,Michelle E Pizzo ,Rachel Prorok ,Elliot Thomsen ,Laura M Bartos ,Philipp Beumers ,Anja Capell ,Sonnet S Davis ,Lis de Weerd ,Jason C Dugas ,Joseph Duque ,Timothy Earr ,Kapil Gadkar ,Tina Giese ,Audrey Gill ,Johannes Gnörich ,Connie Ha ,Malavika Kannuswamy ,Do Jin Kim ,Sebastian T Kunte ,Lea H Kunze ,Diana Lac ,Kendra Lechtenberg ,Amy Wing-Sze Leung ,Chun-Chi Liang ,Isabel Lopez ,Paul McQuade ,Anuja Modi ,Vanessa O Torres ,Hoang N Nguyen ,Ida Pesämaa ,Nicholas Propson ,Marvin Reich ,Yaneth Robles-Colmenares ,Kai Schlepckow ,Luna Slemann ,Hilda Solanoy ,Jung H Suh ,Robert G Thorne ,Chandler Vieira ,Karin Wind-Mark ,Ken Xiong ,Y Joy Yu Zuchero ,Dolo Diaz ,Mark S Dennis ,Fen Huang ,Kimberly Scearce-Levie ,Ryan J Watts ,Christian Haass ,Joseph W Lewcock ,Gilbert Di Paolo ,Matthias Brendel ,Pascal E Sanchez ,Kathryn M Monroe

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

新型应用程序敲入小鼠模型展现了淀粉样蛋白病理的关键特征,并揭示了小胶质细胞严重的代谢紊乱。

Dan Xia # ,Steve Lianoglou # ,Thomas Sandmann ,Meredith Calvert ,Jung H Suh ,Elliot Thomsen ,Jason Dugas ,Michelle E Pizzo ,Sarah L DeVos ,Timothy K Earr ,Chia-Ching Lin ,Sonnet Davis ,Connie Ha ,Amy Wing-Sze Leung ,Hoang Nguyen ,Roni Chau ,Ernie Yulyaningsih ,Isabel Lopez ,Hilda Solanoy ,Shababa T Masoud ,Chun-Chi Liang ,Karin Lin ,Giuseppe Astarita ,Nathalie Khoury ,Joy Yu Zuchero ,Robert G Thorne ,Kevin Shen ,Stephanie Miller ,Jorge J Palop ,Dylan Garceau ,Michael Sasner ,Jennifer D Whitesell ,Julie A Harris ,Selina Hummel ,Johannes Gnörich ,Karin Wind ,Lea Kunze ,Artem Zatcepin ,Matthias Brendel ,Michael Willem ,Christian Haass ,Daniel Barnett ,Till S Zimmer ,Anna G Orr ,Kimberly Scearce-Levie ,Joseph W Lewcock ,Gilbert Di Paolo ,Pascal E Sanchez

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

利用可穿透血脑屏障的生物制剂挽救由 Grn 功能丧失引起的溶酶体贮积症

Todd Logan ,Matthew J Simon ,Anil Rana ,Gerald M Cherf ,Ankita Srivastava ,Sonnet S Davis ,Ray Lieh Yoon Low ,Chi-Lu Chiu ,Meng Fang ,Fen Huang ,Akhil Bhalla ,Ceyda Llapashtica ,Rachel Prorok ,Michelle E Pizzo ,Meredith E K Calvert ,Elizabeth W Sun ,Jennifer Hsiao-Nakamoto ,Yashas Rajendra ,Katrina W Lexa ,Devendra B Srivastava ,Bettina van Lengerich ,Junhua Wang ,Yaneth Robles-Colmenares ,Do Jin Kim ,Joseph Duque ,Melina Lenser ,Timothy K Earr ,Hoang Nguyen ,Roni Chau ,Buyankhishig Tsogtbaatar ,Ritesh Ravi ,Lukas L Skuja ,Hilda Solanoy ,Howard J Rosen ,Bradley F Boeve ,Adam L Boxer ,Hilary W Heuer ,Mark S Dennis ,Mihalis S Kariolis ,Kathryn M Monroe ,Laralynne Przybyla ,Pascal E Sanchez ,Rene Meisner ,Dolores Diaz ,Kirk R Henne ,Ryan J Watts ,Anastasia G Henry ,Kannan Gunasekaran ,Giuseppe Astarita ,Jung H Suh ,Joseph W Lewcock ,Sarah L DeVos ,Gilbert Di Paolo

Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS

RIP1 激酶的基因失活并不能改善小鼠 ALS 模型中的病情

Sara Dominguez, Eugene Varfolomeev, Robert Brendza, Kim Stark, Joy Tea, Jose Imperio, Hai Ngu, Timothy Earr, Oded Foreman, Joshua D Webster, Amy Easton, Domagoj Vucic, Baris Bingol

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

TREM2 在慢性吞噬挑战下调节小胶质细胞胆固醇代谢

Alicia A Nugent, Karin Lin, Bettina van Lengerich, Steve Lianoglou, Laralynne Przybyla, Sonnet S Davis, Ceyda Llapashtica, Junhua Wang, Do Jin Kim, Dan Xia, Anthony Lucas, Sulochanadevi Baskaran, Patrick C G Haddick, Melina Lenser, Timothy K Earr, Ju Shi, Jason C Dugas, Benjamin J Andreone, Todd Log

Characterization of Fluid Biomarkers Reveals Lysosome Dysfunction and Neurodegeneration in Neuronopathic MPS II Patients

体液生物标志物特征分析揭示神经病变型MPS II患者的溶酶体功能障碍和神经退行性变

Bhalla, Akhil; Ravi, Ritesh; Fang, Meng; Arguello, Annie; Davis, Sonnet S; Chiu, Chi-Lu; Blumenfeld, Jessica R; Nguyen, Hoang N; Earr, Timothy K; Wang, Junhua; Astarita, Giuseppe; Zhu, Yuda; Fiore, Damian; Scearce-Levie, Kimberly; Diaz, Dolores; Cahan, Heather; Troyer, Matthew D; Harris, Jeffrey M; Escolar, Maria L

Inducible EphA4 knockout causes motor deficits in young mice and is not protective in the SOD1(G93A) mouse model of ALS

诱导型 EphA4 基因敲除会导致幼鼠出现运动障碍,并且在 SOD1(G93A) 小鼠 ALS 模型中不具有保护作用。

Dominguez, Sara L; Earr, Timothy; Dourado, Michelle; Ngu, Hai; Meilandt, William J; Hanson, Jesse E

Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ

表征 crenezumab 对寡聚 Aβ 的体外和体内选择性结合特性

William J Meilandt, Janice A Maloney, Jose Imperio, Guita Lalehzadeh, Tim Earr, Susan Crowell, Travis W Bainbridge, Yanmei Lu, James A Ernst, Reina N Fuji, Jasvinder K Atwal