日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.

PIP4K2C 抑制可逆转 SARS-CoV-2 引起的自噬通量受损

Karim Marwah, Mishra Manjari, Lo Chieh-Wen, Saul Sirle, Cagirici Halise Busra, Gourdelier Manon, Ghita Luca, Ojha Amrita, Tran Do Hoang Nhu, Agrawal Aditi, McGraw Connor, East Michael P, Gammeltoft Karen Anbro, Sahoo Malaya Kumar, Mooney Nancie A, Johnson Gary L, Das Soumita, Leyssen Pieter, Neyts Johan, Chiu Winston, Cohen Courtney A, Bukh Jens, Gottwein Judith, Dye John M, Neff Norma, Jackson Peter K, Pinsky Benjamin A, Laitinen Tuomo, Pantsar Tatu, Poso Antti, Zanini Fabio, De Jonghe Steven, Asquith Christopher R M, Einav Shirit

Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma

通过表征 EGFRvIII 驱动的胶质母细胞瘤的适应性激酶组重编程,识别和利用组合合成致死性

Lin, Benjamin; Shelton, Abigail K; Smithberger, Erin; Ziebro, Julia; Skinner, Kasey R; Bash, Ryan E; Kirkman, Richard; Stamper, Allie; Butler, Madison; Flores, Alex; Angus, Steven P; East, Michael P; Cloughesy, Timothy F; Nathanson, David A; Berens, Michael E; Sarkaria, Jann N; Binder, Zev A; O'Rourke, Donald M; Howton, Timothy C; Lasseigne, Brittany N; Willey, Christopher D; Johnson, Gary L; Hjelmeland, Anita B; Furnari, Frank B; Miller, C Ryan

Kinome Reprogramming of G2/M Kinases and Repression of MYCN Contribute to Superior Efficacy of Lorlatinib in ALK-Driven Neuroblastoma.

G2/M期激酶的激酶组重编程和MYCN的抑制有助于洛拉替尼在ALK驱动的神经母细胞瘤中发挥更优异的疗效

Matkar Smita, East Michael P, Stuhlmiller Timothy J, Witek Gabriela M, Farrel Alvin, Pastor Steven, Okumu Denis O, Kennedy Anne, Kalna Joshua R, Berko Esther R, Casey Colleen E, Krytska Kateryna, Patel Khushbu, Rokita Jo Lynne, Gerelus Mark, Maris John M, Johnson Gary L, Mossé Yael P

Kinase Plasticity in Response to Vandetanib Enhances Sensitivity to Tamoxifen in Estrogen Receptor Positive Breast Cancer.

凡德他尼诱导的激酶可塑性增强了雌激素受体阳性乳腺癌对三苯氧胺的敏感性

Kakati Rasha T, Whitman Austin A, Haase Santiago, Szenasi Attila T, Thai Christine Hnc, Brunk Elizabeth, Okumu Denis O, East Michael P, Perou Charles M, Johnson Gary L, Spanheimer Philip M

Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships

利用定量构效关系发现和优化窄谱Tousled样激酶2 (TLK2) 抑制剂

Asquith, Christopher R M; East, Michael P; Laitinen, Tuomo; Alamillo-Ferrer, Carla; Hartikainen, Erkka; Wells, Carrow I; Axtman, Alison D; Drewry, David H; Tizzard, Graham J; Poso, Antti; Willson, Timothy M; Johnson, Gary L

Quantitative proteomic mass spectrometry of protein kinases to determine dynamic heterogeneity of the human kinome

利用定量蛋白质组学质谱分析蛋白质激酶,以确定人类激酶组的动态异质性

East, Michael P; Sprung, Robert W; Okumu, Denis O; Olivares-Quintero, J Felix; Joisa, Chinmaya U; Chen, Xin; Zhang, Qiang; Erdmann-Gilmore, Petra; Mi, Yiling; Sciaky, Noah; Malone, James P; Bhatia, Sonam; McCabe, Ian C; Xu, Yi; Sutcliffe, Matthew D; Luo, Jingqin; Spears, Patricia A; Perou, Charles M; Earp, H Shelton; Carey, Lisa A; Yeh, Jen Jen; Spector, David L; Gomez, Shawn M; Spanheimer, Philip M; Townsend, R Reid; Johnson, Gary L

Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships

利用定量构效关系发现和优化Tousled样激酶2(TLK2)的窄谱抑制剂

Asquith, Christopher R M; East, Michael P; Laitinen, Tuomo; Alamillo-Ferrer, Carla; Hartikainen, Erkka; Wells, Carrow I; Axtman, Alison D; Drewry, David H; Tizzard, Graham J; Poso, Antti; Willson, Timothy M; Johnson, Gary L

Adaptive chromatin remodeling and transcriptional changes of the functional kinome in tumor cells in response to targeted kinase inhibition

靶向激酶抑制引起的肿瘤细胞中功能性激酶组的适应性染色质重塑和转录变化

East, Michael P; Johnson, Gary L

Correction to "Mitochondrial Protease ClpP Is a Target for the Anticancer Compounds ONC201 and Related Analogues"

更正“线粒体蛋白酶ClpP是抗癌化合物ONC201及其类似物的靶点”

Graves, Paul R; Aponte-Collazo, Lucas J; Fennell, Emily M J; Graves, Adam C; Hale, Andrew E; Dicheva, Nedyalka; Herring, Laura E; Gilbert, Thomas S K; East, Michael P; McDonald, Ian M; Lockett, Matthew R; Ashamalla, Hani; Moorman, Nathaniel J; Karanewsky, Donald S; Iwanowicz, Edwin J; Holmuhamedov, Ekhson; Graves, Lee M

Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype

鉴定 4-苯胺基喹啉(唑)啉为细胞活性蛋白激酶新型 3 (PKN3) 抑制剂化学型

Asquith, Christopher R M; Temme, Louisa; East, Michael P; Laitinen, Tuomo; Pickett, Julie; Kwarcinski, Frank E; Sinha, Parvathi; Wells, Carrow I; Johnson, Gary L; Zutshi, Reena; Drewry, David H