日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Antibodies toward Na+,HCO3--cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer

针对 Na+、HCO3- 协同转运蛋白 NBCn1/SLC4A7 的抗体可阻断净酸挤出并导致乳腺癌中 pH 依赖性生长抑制和细胞凋亡

Trine V Axelsen, Claus Olesen, Danish Khan, Ali Mohammadi, Elena V Bouzinova, Christine J F Nielsen, Marco Mele, Katrine R Hauerslev, Helene L Pedersen, Eva Balling, Pernille Vahl, Trine Tramm, Peer M Christiansen, Ebbe Boedtkjer

Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer

碳酸酐酶可降低肿瘤微环境的酸度,促进免疫浸润,减缓肿瘤生长,并提高 ErbB2/HER2 富集乳腺癌的生存率

Soojung Lee #, Nicolai J Toft #, Trine V Axelsen, Maria Sofia Espejo, Tina M Pedersen, Marco Mele, Helene L Pedersen, Eva Balling, Tonje Johansen, Mark Burton, Mads Thomassen, Pernille Vahl, Peer Christiansen, Ebbe Boedtkjer

Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival

RPTPγ 的缺失会导致乳腺组织受到酸挤压,促进恶性转化,导致肿瘤早期复发和生存期缩短

Rasmus A Sloth, Trine V Axelsen, Maria Sofia Espejo, Nicolai J Toft, Ninna C S Voss, Mark Burton, Mads Thomassen, Pernille Vahl, Ebbe Boedtkjer

Amplified Ca2+ dynamics and accelerated cell proliferation in breast cancer tissue during purinergic stimulation

嘌呤刺激期间乳腺癌组织中 Ca2+ 动力学增强并加速细胞增殖

Mikkel B Henningsen, Kezia McWhan, Vibeke S Dam, Marco Mele, Katrine R Hauerslev, Ninna C S Voss, Parag D Dabir, Eva Balling, Helene L Pedersen, Pernille Vahl, Tonje Johansen, Trine Tramm, Peer M Christiansen, Ebbe Boedtkjer

NBCn1 Increases NH4 + Reabsorption Across Thick Ascending Limbs, the Capacity for Urinary NH4 + Excretion, and Early Recovery from Metabolic Acidosis

NBCn1 可增加粗上升肢对 NH4 + 的重吸收、尿液 NH4 + 排泄能力以及代谢性酸中毒的早期恢复

Jeppe S M Olsen, Samuel Svendsen, Peder Berg, Vibeke S Dam, Mads V Sorensen, Vladimir V Matchkov, Jens Leipziger, Ebbe Boedtkjer

Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival

人类乳腺癌中的酸碱转运体和 pH 动态可预测增殖活性、转移和存活率

Nicolai J Toft, Trine V Axelsen, Helene L Pedersen, Marco Mele, Mark Burton, Eva Balling, Tonje Johansen, Mads Thomassen, Peer M Christiansen, Ebbe Boedtkjer

PTPRG is an ischemia risk locus essential for HCO3--dependent regulation of endothelial function and tissue perfusion

PTPRG 是缺血风险基因位点,对 HCO3 依赖的内皮功能和组织灌注调节至关重要

Kristoffer B Hansen, Christian Staehr, Palle D Rohde, Casper Homilius, Sukhan Kim, Mette Nyegaard, Vladimir V Matchkov, Ebbe Boedtkjer

Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1

缺乏碳酸氢钠转运体 NBCn1 的小鼠酒精消耗量增加

Jesse R Schank, Soojung Lee, Carlos E Gonzalez-Islas, Sadie E Nennig, Hannah D Fulenwider, Jianjun Chang, Jun Ming Li, Yejin Kim, Lauren A Jeffers, Jaegwon Chung, Jae-Kyung Lee, Zhe Jin, Christian Aalkjaer, Ebbe Boedtkjer, Inyeong Choi

Targeting the Acidic Tumor Microenvironment: Unexpected Pro-Neoplastic Effects of Oral NaHCO3 Therapy in Murine Breast Tissue

针对酸性肿瘤微环境:口服 NaHCO3 疗法对小鼠乳腺组织产生意想不到的促肿瘤作用

Ninna C S Voss, Thomas Dreyer, Mikkel B Henningsen, Pernille Vahl, Bent Honoré, Ebbe Boedtkjer

Enhanced nitric oxide signaling amplifies vasorelaxation of human colon cancer feed arteries

增强的一氧化氮信号增强人类结肠癌供血动脉的血管舒张

Ninna C S Voss, Henrik Kold-Petersen, Ebbe Boedtkjer