日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Recurrent Resistance Mutations to Lirafugratinib Inform Treatment Sequencing in FGFR2-Driven Tumors.

对利拉夫格拉替尼的复发性耐药突变可指导 FGFR2 驱动肿瘤的治疗顺序。

Facchinetti Francesco, Hollebecque Antoine, Barbé Rémy, Jang Dong Man, Alonso-De-Castro Beatriz, Brayé Floriane, Bigot Ludovic, Nobre Catline, Da Silva Alice, Méteau Mélissandre, Delavigne Mathis, Soares Miguel, Italiano Antoine, Rodriguez Julieta, Mosele Fernanda, Beshiri Kristi, Ducreux Michel, Boilève Alice, Nikolaev Sergey, Alonso-Garcia Inmaculada, Vasseur Damien, Smolenschi Cristina, Bourien Héloise, Cotteret Sophie, Samaniego Juliette, Bernard Elsa, Nicotra Claudio, Ngo-Camus Maud, Nakazawa Seshiru, Tselikas Lambros, Badoual Cécile, André Fabrice, Eck Michael J, Olaussen Ken A, Loriot Yohann, Friboulet Luc

Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity.

分子伴侣介导的线粒体导入受体 TOM70 的插入可防止饮食引起的肥胖

Latorre-Muro Pedro, Vitale Tevis, Ravichandran Matthew, Zhang Katherine, Palozzi Jonathan M, Bennett Christopher F, Lamas-Paz Arantza, Sohn Jee Hyung, Jackson Thomas D, Jedrychowski Mark, Gygi Steven P, Kajimura Shingo, Schmoker Anna, Jeon Hyesung, Eck Michael J, Puigserver Pere

Author Correction: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas

作者更正:FGFR 改变和共突变的多样性提示了儿童低级别胶质瘤的潜在治疗策略。

Apfelbaum, April A; Morin, Eric; Sturm, Dominik; Ayoub, Georges; DiGiacomo, Jeromy; Bahadur, Sher; Chandarana, Bhavyaa; Power, Phoebe C; Cusick, Margaret M; Novikov, Dana; Prabhakar, Prem; Jones, Robert E; Vogelzang, Jayne; Bossi, Connor C; Malinowski, Seth; Woodward, Lewis M; Jones, Tania A; Jeang, John; Lamson, Sarah W; Collins, Jared; Cai, Kelly Y; Jones, Jacquelyn S; Oh, Sehee; Jeon, Hyesung; Wang, Jinhua; Cameron, Amy; Rechter, Patrick; De Leon, Angela; Murugesan, Karthikeyan; Montesion, Meagan; Albacker, Lee A; Ramkissoon, Shakti H; van Tilburg, Cornelis M; Hardin, Emily C; Sievers, Philipp; Sahm, Felix; Yeo, Kee Kiat; Rosenberg, Tom; Chi, Susan N; Wright, Karen D; Hébert, Steven; Peck, Sydney; Picca, Alberto; Larouche, Valérie; Renzi, Samuele; Buhrlage, Sara J; Bale, Tejus A; Smith, Amy A; Touat, Mehdi; Jabado, Nada; Fischer, Eric S; Eck, Michael J; Baird, Lissa; Witt, Olaf; Kleinman, Claudia L; Nguyen, Quang-De; Sheer, Denise; Alexandrescu, Sanda; Jones, David T W; Ligon, Keith L; Bandopadhayay, Pratiti

A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas.

FGFR 改变和共突变的多样性提示了儿童低级别胶质瘤的潜在治疗策略

Apfelbaum April A, Morin Eric, Sturm Dominik, Ayoub Georges, DiGiacomo Jeromy, Bahadur Sher, Chandarana Bhavyaa, Power Phoebe C, Cusick Margaret M, Novikov Dana, Prabhakar Prem, Jones Robert E, Vogelzang Jayne, Bossi Connor C, Malinowski Seth, Woodward Lewis M, Jones Tania A, Jeang John, Lamson Sarah W, Collins Jared, Cai Kelly Y, Jones Jacquelyn S, Oh Sehee, Jeon Hyesung, Wang Jinhua, Cameron Amy, Rechter Patrick, De Leon Angela, Murugesan Karthikeyan, Montesion Meagan, Albacker Lee A, Ramkissoon Shakti H, van Tilburg Cornelis M, Hardin Emily C, Sievers Philipp, Sahm Felix, Yeo Kee Kiat, Rosenberg Tom, Chi Susan N, Wright Karen D, Hébert Steven, Peck Sydney, Picca Alberto, Larouche Valérie, Renzi Samuele, Buhrlage Sara J, Bale Tejus A, Smith Amy A, Touat Mehdi, Jabado Nada, Fischer Eric S, Eck Michael J, Baird Lissa, Witt Olaf, Kleinman Claudia L, Nguyen Quang-De, Sheer Denise, Alexandrescu Sanda, Jones David T W, Ligon Keith L, Bandopadhayay Pratiti

Cryo-EM structures of CRAF/MEK1/14-3-3 complexes in autoinhibited and open-monomer states reveal features of RAF regulation.

CRAF/MEK1/14-3-3 复合物在自身抑制和开放单体状态下的冷冻电镜结构揭示了 RAF 调控的特征

Jang Dong Man, Boxer Kayla, Ha Byung Hak, Tkacik Emre, Levitz Talya, Rawson Shaun, Metivier Rebecca J, Schmoker Anna, Jeon Hyesung, Eck Michael J

Characterization and inhibitor sensitivity of ARAF, BRAF, and CRAF kinases

ARAF、BRAF 和 CRAF 激酶的特性及抑制剂敏感性

Tkacik, Emre; Jang, Dong Man; Boxer, Kayla; Ha, Byung Hak; Eck, Michael J

Structure-Activity Relationships of Inactive-Conformation Binding EGFR Inhibitors: Linking the ATP and Allosteric Pockets

非活性构象结合型 EGFR 抑制剂的构效关系:ATP 结合口袋与变构口袋的联系

Chitnis, Surbhi P; Wittlinger, Florian; Möllers, Mareike; Hartman, Tyler J; Günther, Marcel; Eck, Michael J; Laufer, Stefan A; Heppner, David E

Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality

具有两个亲电弹头的分子双螺旋结构作为一种新型药理学模式

Li, Zhengnian; Jiang, Jie; Ficarro, Scott B; Beyett, Tyler S; To, Ciric; Tavares, Isidoro; Zhu, Yingde; Li, Jiaqi; Eck, Michael J; Jänne, Pasi A; Marto, Jarrod A; Zhang, Tinghu; Che, Jianwei; Gray, Nathanael S

Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent "Type V" Kinase Inhibitors

向EGFR突变体选择性倾斜:扩大二价“V型”激酶抑制剂的范围

Wittlinger, Florian; Chitnis, Surbhi P; Pham, Calvin D; Damghani, Tahereh; Patel, Kishan B; Möllers, Mareike; Schaeffner, Ilse K; Abidakun, Omobolanle A; Deng, Matthew Q; Ogboo, Blessing C; Rasch, Alexander; Beyett, Tyler S; Buckley, Brian; Feru, Frederic; Shaurova, Tatiana; Knappe, Cornelius; Eck, Michael J; Hershberger, Pamela A; Scott, David A; Brandt, Asher L; Laufer, Stefan A; Heppner, David E

Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase

大环抑制剂BI-4020与EGFR激酶结合的结构分析

Beyett, Tyler S; Rana, Jaimin K; Schaeffner, Ilse K; Heppner, David E; Eck, Michael J