日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Versatile Imidazole Scaffold with Potent Activity against Multiple Apicomplexan Parasites.

多功能咪唑骨架,对多种顶复门寄生虫具有强效活性

Khim Monique, Montgomery Jemma, Laureano De Souza Mariana, Delvillar Melvin, Weible Lyssa J, Prabakaran Mayuri, Hulverson Matthew A, Eck Tyler, Bheemanabonia Rammohan Y, Alday P Holland, Rotella David P, Doggett J Stone, Staker Bart L, Ojo Kayode K, Bhanot Purnima

Crystal structure of dihydrofolate reductase from the filarial nematode W. bancrofti in complex with NADPH and folate

丝虫病线虫班氏丝虫二氢叶酸还原酶与 NADPH 和叶酸复合物的晶体结构

Lange, Keith; Frey, Kathleen M; Eck, Tyler; Janson, Cheryl A; Gubler, Ueli; Goodey, Nina M

Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase

发现基于异噁唑基的恶性疟原虫cGMP依赖性蛋白激酶抑制剂

Mahmood, Shams Ul; Cheng, Huimin; Tummalapalli, Sreedhar R; Chakrasali, Ramappa; Yadav Bheemanaboina, Rammohan R; Kreiss, Tamara; Chojnowski, Agnieska; Eck, Tyler; Siekierka, John J; Rotella, David P

Mutational analysis confirms the presence of distal inhibitor-selectivity determining residues in B. stearothermophilus dihydrofolate reductase.

突变分析证实了嗜热芽孢杆菌二氢叶酸还原酶中存在远端抑制剂选择性决定残基

Eck Tyler, Patel Seema, Candela Thomas, Leon H Katherine, Little Michael, Reis Natalia E, Liyanagunawardana Uththara, Gubler Ueli, Janson Cheryl A, Catalano Jaclyn, Goodey Nina M

Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti

丝虫病线虫班氏丝虫二氢叶酸还原酶的表达、纯化和抑制谱

Tobias, Andrew M; Toska, Dea; Lange, Keith; Eck, Tyler; Bhat, Rohit; Janson, Cheryl A; Rotella, David P; Gubler, Ueli; Goodey, Nina M