日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors

NOTCH1 激活突变定义了腺样囊性癌患者中的一个独特亚组,该亚组患者预后不良,易发生骨和肝转移,并且可能对 Notch1 抑制剂有反应。

Ferrarotto, Renata; Mitani, Yoshitsugu; Diao, Lixia; Guijarro, Irene; Wang, Jing; Zweidler-McKay, Patrick; Bell, Diana; William, William N Jr; Glisson, Bonnie S; Wick, Michael J; Kapoun, Ann M; Patnaik, Amita; Eckhardt, Gail; Munster, Pamela; Faoro, Leonardo; Dupont, Jakob; Lee, J Jack; Futreal, Andrew; El-Naggar, Adel K; Heymach, John V

A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer.

NOTCH1 基因拷贝数增加是预后不良的指标,也是结直肠癌中 Notch1 靶向抗体的预测性生物标志物

Arcaroli John J, Tai W M, McWilliams Ryan, Bagby Stacey, Blatchford Patrick J, Varella-Garcia Marileila, Purkey Alicia, Quackenbush Kevin S, Song Eun-Kee, Pitts Todd M, Gao Dexiang, Lieu Chris, McManus Martine, Tan Aik Choon, Zheng Xianxian, Zhang Qin, Ozeck Mark, Olson Peter, Jiang Zhi-Qin, Kopetz Scott, Jimeno Antonio, Keysar Stephen, Eckhardt Gail, Messersmith Wells A

Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model

卡博替尼(一种 c-MET 和 VEGFR2 抑制剂)在结直肠癌患者来源的肿瘤外植体模型中表现出强大的抗肿瘤活性

Song, Eun-Kee; Tai, W M; Messersmith, Wells A; Bagby, Stacey; Purkey, Alicia; Quackenbush, Kevin S; Pitts, Todd M; Wang, Guoliang; Blatchford, Patrick; Yahn, Rachel; Kaplan, Jeffrey; Tan, Aik Choon; Atreya, Chloe E; Eckhardt, Gail; Kelley, Robin K; Venook, Alan; Kwak, Eunice L; Ryan, David; Arcaroli, John J

Role of ubiquitin ligases and the proteasome in oncogenesis: novel targets for anticancer therapies

泛素连接酶和蛋白酶体在肿瘤发生中的作用:抗癌治疗的新靶点

Micel, Lindsey N; Tentler, John J; Smith, Peter G; Eckhardt, Gail S

Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment

美国国家癌症研究所胰腺癌治疗临床试验计划会议共识报告

Philip, Philip A; Mooney, Margaret; Jaffe, Deborah; Eckhardt, Gail; Moore, Malcolm; Meropol, Neal; Emens, Leisha; O'Reilly, Eileen; Korc, Murray; Ellis, Lee; Benedetti, Jacqueline; Rothenberg, Mace; Willett, Christopher; Tempero, Margaret; Lowy, Andrew; Abbruzzese, James; Simeone, Diane; Hingorani, Sunil; Berlin, Jordan; Tepper, Joel