日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase

双环氮杂环丁烷类化合物通过抑制寄生虫苯丙氨酰-tRNA合成酶,杀死小鼠体内引起腹泻的病原体隐孢子虫。

Vinayak, Sumiti; Jumani, Rajiv S; Miller, Peter; Hasan, Muhammad M; McLeod, Briana I; Tandel, Jayesh; Stebbins, Erin E; Teixeira, Jose E; Borrel, Julien; Gonse, Arthur; Zhang, Mingliang; Yu, Xianshui; Wernimont, Amy; Walpole, Chris; Eckley, Sean; Love, Melissa S; McNamara, Case W; Sharma, Manmohan; Sharma, Amit; Scherer, Christina A; Kato, Nobutaka; Schreiber, Stuart L; Melillo, Bruno; Striepen, Boris; Huston, Christopher D; Comer, Eamon

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

H3B-8800 是一种口服的小分子剪接调节剂,可导致剪接体突变型癌症细胞死亡。

Michael Seiler ,Akihide Yoshimi ,Rachel Darman ,Betty Chan ,Gregg Keaney ,Michael Thomas ,Anant A Agrawal ,Benjamin Caleb ,Alfredo Csibi ,Eckley Sean ,Peter Fekkes ,Craig Karr ,Virginia Klimek ,George Lai ,Linda Lee ,Pavan Kumar ,Stanley Chun-Wei Lee ,Xiang Liu ,Crystal Mackenzie ,Carol Meeske ,Yoshiharu Mizui ,Eric Padron ,Eunice Park ,Ermira Pazolli ,Shouyong Peng ,Sudeep Prajapati ,Justin Taylor ,Teng Teng ,John Wang ,Markus Warmuth ,Huilan Yao ,Lihua Yu ,Ping Zhu ,Omar Abdel-Wahab ,Peter G Smith ,Silvia Buonamici

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

多样性导向合成产生新型多阶段抗疟疾抑制剂

Kato Nobutaka, Comer Eamon, Sakata-Kato Tomoyo, Sharma Arvind, Sharma Manmohan, Maetani Micah, Bastien Jessica, Brancucci Nicolas M, Bittker Joshua A, Corey Victoria, Clarke David, Derbyshire Emily R, Dornan Gillian L, Duffy Sandra, Eckley Sean, Itoe Maurice A, Koolen Karin M J, Lewis Timothy A, Lui Ping S, Lukens Amanda K, Lund Emily, March Sandra, Meibalan Elamaran, Meier Bennett C, McPhail Jacob A, Mitasev Branko, Moss Eli L, Sayes Morgane, Van Gessel Yvonne, Wawer Mathias J, Yoshinaga Takashi, Zeeman Anne-Marie, Avery Vicky M, Bhatia Sangeeta N, Burke John E, Catteruccia Flaminia, Clardy Jon C, Clemons Paul A, Dechering Koen J, Duvall Jeremy R, Foley Michael A, Gusovsky Fabian, Kocken Clemens H M, Marti Matthias, Morningstar Marshall L, Munoz Benito, Neafsey Daniel E, Sharma Amit, Winzeler Elizabeth A, Wirth Dyann F, Scherer Christina A, Schreiber Stuart L